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    Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6711-5.

    Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

    Lowenstein CJ, Glatt CS, Bredt DS, Snyder SH.

    Department of Neuroscience, Johns Hopkins Medical Institutions, Baltimore, MD 21205.

    Nitric oxide (NO) is a messenger molecule of macrophages, endothelial cells in blood vessels, and neurons. A neuronal form of NO synthase (NOS) has been previously cloned. We now report the molecular cloning of macrophage NOS. The macrophage enzyme displays 50% sequence identity to the neuronal enzyme. Like neuronal NOS, macrophage NOS has recognition sites for FAD, FMN, and NADPH and also has a consensus calmodulin binding site. Macrophage NOS mRNA is strikingly inducible; it is absent in quiescent macrophages or spleen but is prominent 2-6 hr after endotoxin treatment.

    PMID: 1379716 [PubMed - indexed for MEDLINE]

    PMCID: 49573

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