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    Biochem Biophys Res Commun. 1992 Apr 30;184(2):733-8.

    cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein.

    Hung DT, Schreiber SL.

    Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138.

    The abilities of FK506 and rapamycin to block distinct signal transduction pathways are mediated by soluble binding proteins. Previously, a family of these receptors has been recognized that includes a 25 kDa protein, FKBP25. We now report the isolation of a cDNA for FKBP25 from a human hippocampal cDNA library by oligonucleotide screening. The nucleotide sequence reveals an open reading frame that encodes a 224 amino acid polypeptide. Human FKBP25 shows 97% amino acid identity with bovine FKBP25 and 62% homology with human FKBP12.

    PMID: 1374240 [PubMed - indexed for MEDLINE]

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