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    Brain Res Mol Brain Res. 1992 Jan;12(1-3):275-7.

    Characterization of two cDNAs encoding insulin-like growth factor 1 (IGF-1) in the human fetal brain.

    Sandberg-Nordqvist AC, Ståhlbom PA, Lake M, Sara VR.

    Karolinska Institute's Department of Pathology, Karolinska Hospital, Stockholm, Sweden.

    Insulin-like growth factor 1 (IGF-1) regulates growth of the brain. In order to characterize the variant IGF-1 present in human fetal brain we have determined the cDNA sequence for human fetal brain IGF-1. Using PCR to amplify cDNA obtained from isolated human fetal brain mRNA, two cDNA sequences encoding precursor proteins which correspond to IGF-1a and IGF-1b were obtained. This is the first characterisation of IGF-1 and its IGF-1a and IGF-1b precursors in the nervous system.

    PMID: 1372070 [PubMed - indexed for MEDLINE]

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