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    Br J Cancer. 1992 Jan;65(1):65-71.

    Differential expression of translation-associated genes in benign and malignant human breast tumours.

    Adams SM, Sharp MG, Walker RA, Brammar WJ, Varley JM.

    University/ICI Joint Laboratory, University of Leicester, UK.

    The human gene sequences encoding the translation-associated functions of alpha-subunit of elongation factor 1 (EF-1 alpha) and the ubiquitin carboxyl extension protein (HUBCEP80) have been isolated by differential cDNA screening, and found to have significantly higher levels of expression in fibroadenomas (benign) compared with carcinomas (malignant) of the breast. These data parallel our previous findings that the acidic ribosomal phosphoprotein P2 also has higher expression levels in the benign breast tumours (Sharp et al., 1990). In situ hybridisation has shown these genes to be expressed predominantly in the epithelium of breast tumours.

    PMID: 1370760 [PubMed - indexed for MEDLINE]

    PMCID: 1977345

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