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    Genomics. 1992 Jan;12(1):74-9.

    The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1.

    Leung TK, Hall C, Rajendran M, Spurr NK, Lim L.

    Department of Neurochemistry, Institute of Neurology, London, United Kingdom.

    HSPA6 is a member of the human heat-shock protein gene family, encoding a basic 70-kDa protein, with unique induction characteristics (Leung et al., 1990, Biochem. J. 267: 125-132). Hybridization analyses with a somatic cell hybrid DNA panel localized the gene to chromosome 1q. The highly related HSPA7 DNA sequence (Voellmy et al., 1985, Proc. Natl. Acad. Sci. USA 82: 4949-4953) colocalized. Both HSPA6 and HSPA7 represent functional genes, as determined by analyses of mRNA from heat-shocked human cells using specific oligonucleotides, although their pattern of expression differed. Neither mRNA was detected in the absence of heat stress. A BamHI polymorphism in the HSPA7 gene was present in a predominantly Asian population.

    PMID: 1346391 [PubMed - indexed for MEDLINE]

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