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    Genomics. 1992 Dec;14(4):1092-4.

    Mapping of a human brain voltage-gated calcium channel to human chromosome 12p13-pter.

    Sun W, McPherson JD, Hoang DQ, Wasmuth JJ, Evans GA, Montal M.

    Department of Biology, University of California San Diego, La Jolla 92093-0319.

    Degenerate DNA oligomers coding for highly conserved regions of the voltage-gated calcium channel were synthesized for the polymerase chain reaction (PCR) using DNA from a human brain cDNA library as template. PCR amplified a 640-bp DNA fragment from the human brain cDNA library. Sequencing revealed that this fragment encodes part of a protein highly homologous to a subtype of the dihydropyridine-sensitive calcium channel cloned from rabbit heart and rat brain. Southern analysis of panels of somatic cell hybrids mapped the 640-bp fragment, CACNL1A1, to human chromosome 12p13-pter.

    PMID: 1335957 [PubMed - indexed for MEDLINE]

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