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    Biochem Biophys Res Commun. 2003 Apr 18;303(4):1186-92.

    Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy.

    Lutz W, Frank EM, Craig TA, Thompson R, Venters RA, Kojetin D, Cavanagh J, Kumar R.

    Department of Biochemistry, Research Center, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA.

    Calbindin D(28K) is an EF-hand containing protein that plays a vital role in neurological function. We now show that calcium-loaded calbindin D(28K) interacts with Ran-binding protein M, a protein known to play a role in microtubule function. Using NMR methods, we show that a peptide, LASIKNR, derived from Ran-binding protein M, interacts with several regions of the calcium-loaded protein including the amino terminus and two other regions that exhibit conformational exchange on the NMR timescale. We suggest that the interaction between calbindin D(28K) and Ran-binding protein M may be important in calbindin D(28K) function.

    PMID: 12684061 [PubMed - indexed for MEDLINE]

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