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    Exp Gerontol. 2003 Mar;38(3):245-52.

    A novel putative collaborator of p19ARF.

    Wadhwa R, Sugihara T, Hasan MK, Duncan EL, Taira K, Kaul SC.

    Gene Function Research Laboratory, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.

    We performed a yeast interactive screen in search of p19(ARF)-binding partners and have isolated a novel serine rich protein that is assigned to human chromosome 4q35 and mouse chromosome 8. The human and mouse proteins showed 84.2% homology. It is named CARF for its role as a putative Collaborator of ARF. CARF binds to both mouse and human ARF proteins. Its expression was detected in a variety of human tissues. The cDNA was expressed in bacteria and mammalian cells as a soluble and predominantly nucleoplasmic protein, respectively. CARF is a novel binding partner of ARF and might be involved in its p53-dependent or -independent tumor suppressive functions.

    PMID: 12581788 [PubMed - indexed for MEDLINE]

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