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    Nat Rev Mol Cell Biol. 2003 Feb;4(2):95-104.

    NALPs: a novel protein family involved in inflammation.

    Tschopp J, Martinon F, Burns K.

    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland. jurg.tschopp@ib.unil.ch

    A newly discovered family of cytoplasmic proteins--the NALPs--has been implicated in the activation of caspase-1 by the Toll-like receptors (TLRs) during the cell's response to microbial infection. Like the structurally related apoptotic protease-activating factor-1 (APAF-1), which is responsible for the activation of caspase-9, the NALP1 protein forms a large, signal-induced multiprotein complex, the inflammasome, resulting in the activation of pro-inflammatory caspases.

    PMID: 12563287 [PubMed - indexed for MEDLINE]

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