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    J Biol Chem. 2003 Mar 7;278(10):8630-6. Epub 2002 Dec 20.

    High resolution structure, stability, and synaptotagmin binding of a truncated neuronal SNARE complex.

    Ernst JA, Brunger AT.

    Howard Hughes Medical Institute, Stanford University, California 94305, USA.

    The structure of a truncated SNARE complex has been solved to 1.4-A resolution revealing a stabilizing salt bridge, sites of hydration, and conformational variability of the ionic central layer that were not observed in a previously published structure at 2.4-A resolution (Sutton, R. B., Fasshauer, D., Jahn, R., and Brunger, A. T. (1998) Nature 395, 347-353). The truncated complex lacks residues involved in phospholipid binding and denatures at a lower temperature than longer complexes as assessed by SDS and circular dichroism thermal melts. The truncated SNARE complex is monomeric, and it retains binding to synaptotagmin I.

    PMID: 12496247 [PubMed - indexed for MEDLINE]

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