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    Antimicrob Agents Chemother. 2002 Jun;46(6):2014-6.

    Detection of a variant metallo-beta-lactamase, IMP-10, from two unrelated strains of Pseudomonas aeruginosa and an alcaligenes xylosoxidans strain.

    Iyobe S, Kusadokoro H, Takahashi A, Yomoda S, Okubo T, Nakamura A, O'Hara K.

    Laboratory of Drug Resistance in Bacteria, Gunma University School of Medicine, Maebashi, Japan. siyobe@med.gunma-u.ac.jp

    The gene bla(IMP-10) of a variant metallo-beta-lactamase, IMP-10, had a single base replacement of G by T at nucleotide 145, which led to an amino acid alteration of Val49 to Phe compared to the IMP-1 enzyme, indicating that IMP-10 was a point mutation derivative of IMP-1. Highly purified enzymes revealed that IMP-10 was different from IMP-1 in its extremely low hydrolyzing activities for penicillins, such as benzylpenicillin, ampicillin, and piperacillin.

    PMID: 12019129 [PubMed - indexed for MEDLINE]

    PMCID: 127220

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