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    Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):291-6. Epub 2001 Dec 18.

    Sequence analysis of mouse vomeronasal receptor gene clusters reveals common promoter motifs and a history of recent expansion.

    Lane RP, Cutforth T, Axel R, Hood L, Trask BJ.

    Department of Molecular Biotechnology, University of Washington, Seattle, WA 98195,USA. rlane@fhcrc.org

    We have analyzed the organization and sequence of 73 V1R genes encoding putative pheromone receptors to identify regulatory features and characterize the evolutionary history of the V1R family. The 73 V1Rs arose from seven ancestral genes around the time of mouse-rat speciation through large local duplications, and this expansion may contribute to speciation events. Orthologous V1R genes appear to have been lost during primate evolution. Exceptional noncoding homology is observed across four V1R subfamilies at one cluster and thus may be important for locus-specific transcriptional regulation.

    PMID: 11752409 [PubMed - indexed for MEDLINE]

    PMCID: 117554

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