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    Arch Virol. 2001 Oct;146(10):2021-7.

    Genome structure of Ebola virus subtype Reston: differences among Ebola subtypes. Brief report.

    Ikegami T, Calaor AB, Miranda ME, Niikura M, Saijo M, Kurane I, Yoshikawa Y, Morikawa S.

    Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan.

    We determined the complete genome sequence of Ebola virus subtype Reston (EBO-R) in the Philippines in 1996. The deduced transcriptional signals were highly conserved among Ebola viruses except for the stop signal of L genes. The intergenic regions were composed of 4 to 7 nucleotides, and of 2 characteristic overlaps and a long intergenic region. The glycoprotein (GP) had several amino acid differences from EBO-R isolated in 1989 and 1992. The variety of GP sequences strongly suggests the independent introduction of EBO-R from unknown natural reservoirs in 1996.

    PMID: 11722021 [PubMed - indexed for MEDLINE]

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