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    Toxicon. 2001 Nov;39(11):1747-55.

    Toxins of Bacillus anthracis.

    Brossier F, Mock M.

    Unité des Toxines et Pathogénie Bactériennes (URA CNRS 2172), Institut Pasteur, 28 rue du Docteur Roux, 75725 15, Paris Cedex, France.

    Bacillus anthracis, a gram positive bacterium, is the causative agent of anthrax. This organism is capsulogen and toxinogenic. It secretes two toxins which are composed of three proteins: the protective antigen (PA), the lethal factor (LF) and the edema factor (EF). The lethal toxin (PA+LF) provokes a subit death in animals, the edema toxin (PA+EF) induces edema. The edema and the lethal factors are internalised into the eukaryotic target cells via the protective antigen. EF and LF exert a calmoduline dependent adenylate cyclase and a metalloprotease activity respectively. Progress in the structure-function relationship of these three proteins, their regulation mechanisms and their roles in pathogenesis and immunoprotection will be exposed.

    PMID: 11595637 [PubMed - indexed for MEDLINE]

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