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Cell Signal. 2001 Jun;13(6):389-400.

The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.

Wajant H, Henkler F, Scheurich P.

Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany. harld.wajant@po.uni-stuttgart.de

The TNF-receptor-associated factor (TRAF) family is a phylogenetically conserved group of scaffold proteins that link receptors of the IL-1R/Toll and TNF receptor family to signalling cascades, leading to the activation of NF-kappaB and mitogen-activated protein kinases. Furthermore, TRAF proteins serve as a docking platform for a variety of regulators of these signalling pathways and are themselves often regulated at the transcriptional and posttranslational level. In this review, we address the structural and molecular basis of TRAF protein functions and highlight their role in cytokine signalling.

PMID: 11384837 [PubMed - indexed for MEDLINE]

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