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    Schizophr Res. 2001 Jan 15;47(1):99-103.

    Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia.

    Bolonna AA, Kerwin RW, Munro J, Arranz MJ, Makoff AJ.

    Department of Psychological Medicine, Section of Clinical Neuropharmacology, Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK. spbcaab@iop.kcl.ac.uk

    A dysfunctional glutamatergic system has been implicated in the pathophysiology of schizophrenia. The group III metabotropic glutamate receptor (mGluR) types 7 and 8 presynaptically inhibit glutamate release, thereby modulating glutamatergic transmission in the brain. We conducted association studies to investigate the novel Tyr433Phe (mGluR7) variant and the 2846-C/T (mGluR8) polymorphism in schizophrenia. Both variants, present at high frequencies, failed to demonstrate any significant association with schizophrenia (mGluR7 [Tyr433Phe] allele: P=0.33; genotype: P=0.63; mGluR8 [2846-C/T] allele: P=0.72; genotype: P=0.63).

    PMID: 11163549 [PubMed - indexed for MEDLINE]

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