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    Gene. 2000 Oct 3;256(1-2):113-21.

    Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo.

    Duan W, Sun B, Li TW, Tan BJ, Lee MK, Teo TS.

    Department of Biochemistry, Faculty of Medicine, The National University of Singapore, 10 Kent Ridge Crescent, 119260, Singapore, Singapore.

    We describe the cloning and expression of cDNAs encoding a novel human protein of 208 amino acid residues with a predicted molecular mass of 22.6kDa and its mouse homologue. We name this protein as AWP1 (associated with PRK1). AWP1 is a ubiquitously expressed protein, and the Awp1 gene is switched on during early human and mouse development. When expressed in COS-1 cells, the Myc-tagged AWP1 has an apparent molecular mass higher than that deduced from its amino acid sequence. AWP1 possesses a conserved zf-A20 zinc finger domain at its N-terminal and a zf-AN1 zinc finger domain at its C-terminal. Co-immunoprecipitation experiments revealed that mouse AWP1 specifically interacts with a rat serine/threonine protein kinase PRK1 in vivo. Hence, AWP1 may play a regulatory role in mammalian signal transduction pathways.

    PMID: 11054541 [PubMed - indexed for MEDLINE]

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