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    Genes Dev. 2000 Jun 1;14(11):1313-8.

    Dll4, a novel Notch ligand expressed in arterial endothelium.

    Shutter JR, Scully S, Fan W, Richards WG, Kitajewski J, Deblandre GA, Kintner CR, Stark KL.

    Departments of Molecular Genetics, Amgen, Inc., Thousand Oaks, California 91320 USA.

    We report the cloning and characterization of a new member of the Delta family of Notch ligands, which we have named Dll4. Like other Delta genes, Dll4 is predicted to encode a membrane-bound ligand, characterized by an extracellular region containing several EGF-like domains and a DSL domain required for receptor binding. In situ analysis reveals a highly selective expression pattern of Dll4 within the vascular endothelium. The activity and expression of Dll4 and the known actions of other members of this family suggest a role for Dll4 in the control of endothelial cell biology.

    PMID: 10837024 [PubMed - indexed for MEDLINE]

    PMCID: 316657

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