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    J Mol Biol. 2000 Feb 18;296(2):351-9.

    Solution structure and dynamics of the DNA-binding domain of the adipocyte-transcription factor FREAC-11.

    van Dongen MJ, Cederberg A, Carlsson P, Enerbäck S, Wikström M.

    Department of Structural Chemistry, Pharmacia and Upjohn, Nordenflychtsvägen 62:5, Stockholm, S-11287, Sweden. maria.vandongen@eu.pnu.com

    Transcription factors of the forkhead type share a highly conserved DNA-binding domain of about 100 amino acid residues. FREAC-11, expressed in adipocytes, belongs to this class. Here, we report on NMR studies that established the three-dimensional structure of the FREAC-11, DNA-binding domain. Although apparent similarities to the structures of other members within the forkhead family are observed, the structure also reveals some remarkable differences. Along with the complementary dynamics, the data provide insight into the fundamentals of sequence specificity within a highly conserved motif. Copyright 2000 Academic Press.

    PMID: 10669593 [PubMed - indexed for MEDLINE]

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