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    Genomics. 2000 Jan 1;63(1):133-8.

    Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene.

    Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L.

    Department of Molecular Biotechnology, University of Washington, Seattle, Washington 98195, USA.

    The genomic sequence of the human Jagged2 (JAG2) gene, which encodes a ligand for the Notch receptors, was determined. The 30-kb DNA sequence spanning the JAG2 gene contains 26 exons and a putative promoter region. Several potential binding sites for transcription factors, including NF-kappab, E47, E12, E2F, Ets-1, MyoD, and OCT-1, were found in the human JAG2 promoter region. The JAG2 gene was also mapped to the chromosomal region 14q32 using fluorescence in situ hybridization. Copyright 2000 Academic Press.

    PMID: 10662552 [PubMed - indexed for MEDLINE]

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