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    J Biol Chem. 2000 Jan 14;275(2):1169-75.

    Four new members expand the interleukin-1 superfamily.

    Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE.

    Immunex Corp., Seattle, Washington 98101, USA.

    We report here the cloning and characterization of four new members of the interleukin-1 (IL-1) family (FIL1delta, FIL1epsilon, FIL1zeta, and FIL1eta, with FIL1 standing for "Family of IL-1"). The novel genes demonstrate significant sequence similarity to IL-1alpha, IL-1beta, IL-1ra, and IL-18, and in addition maintain a conserved exon-intron arrangement that is shared with the previously known members of the family. Protein structure modeling also suggests that the FIL1 genes are related to IL-1beta and IL-1ra. The novel genes form a cluster with the IL-1s on the long arm of human chromosome 2.

    PMID: 10625660 [PubMed - indexed for MEDLINE]

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