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    Science. 1999 Jul 2;285(5424):107-10.

    Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein.

    Taylor DR, Shi ST, Romano PR, Barber GN, Lai MM.

    Department of Molecular Microbiology and Immunology and Howard Hughes Medical Institute, University of Southern California, School of Medicine, Los Angeles, CA 90089, USA.

    Comment in:

    Most isolates of hepatitis C virus (HCV) infections are resistant to interferon, the only available therapy, but the mechanism underlying this resistance has not been defined. Here it is shown that the HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PKR and the translation initiation factor eIF2alpha, a target of PKR. E2 inhibited the kinase activity of PKR and blocked its inhibitory effect on protein synthesis and cell growth. This interaction of E2 and PKR may be one mechanism by which HCV circumvents the antiviral effect of interferon.

    PMID: 10390359 [PubMed - indexed for MEDLINE]

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