pzg putzig [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: pzgprovided by FlyBase
Official Full Name: putzigprovided by FlyBase
Primary source: FLYBASE:FBgn0259785
Locus tag: Dmel_CG7752
See related: AllianceGenome:FB:FBgn0259785
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7752; Dmel\CG7752; p160; Pzg; Pzg/Z4; Q9VP57_DROME; z4; Z4
Summary: Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including ecdysone receptor-mediated signaling pathway; negative regulation of receptor signaling pathway via JAK-STAT; and positive regulation of mitotic cell cycle. Located in nucleus and polytene chromosome interband. Is expressed in several structures, including adult heart; ectoderm; embryonic/larval midgut; extended germ band embryo; and wing disc. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 78C5-78C6; 3-47 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (21286099..21290310)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (21279199..21283410)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The BEAF-32 Protein Directly Interacts with Z4/putzig and Chriz/Chromator Proteins in Drosophila melanogaster.
Title: The BEAF-32 Protein Directly Interacts with Z4/putzig and Chriz/Chromator Proteins in Drosophila melanogaster.
The Chriz Protein Promotes the Recruitment of the Z4 Protein to the STAT-Dependent Promoters.
Title: The Chriz Protein Promotes the Recruitment of the Z4 Protein to the STAT-Dependent Promoters.
Loss of putzig in the germline impedes germ cell development by inducing cell death and new niche like microenvironments.
Title: Loss of putzig in the germline impedes germ cell development by inducing cell death and new niche like microenvironments.
downregulation of pzg activity in the developing wing imaginal discs induces an apoptotic response.
Title: Loss of putzig Activity Results in Apoptosis during Wing Imaginal Development in Drosophila.
JIL-1 and Z4 (also known as Putzig), which are necessary for establishing a fine-tuned regulation of the transcription of the major component of Drosophila telomeres, the HeT-A retrotransposon, thus guaranteeing genome stability
Title: The chromosomal proteins JIL-1 and Z4/Putzig regulate the telomeric chromatin in Drosophila melanogaster.
Chriz and Z4 form a complex that recruits the JIL-1 kinase to polytene chromosomes, enabling local H3S10 phosphorylation of interband nucleosomal histones.
Title: The Chriz-Z4 complex recruits JIL-1 to polytene chromosomes, a requirement for interband-specific phosphorylation of H3S10.
Pzg is associated with EcR in vivo and required for the transcriptional induction of EcR target genes, whereas reduced ecdysteroid levels imply a NURF-independent function of Pzg.
Title: The Putzig-NURF nucleosome remodeling complex is required for ecdysone receptor signaling and innate immunity in Drosophila melanogaster.
These data suggest a novel Putzig-nuclear remodeling factor chromatin complex required for epigenetic activation of Notch targets.
Title: A novel Pzg-NURF complex regulates Notch target gene activity.
These findings uncover different modes of operation of Putzig (pzg) during imaginal development of Drosophila, and they provide a novel mechanism of Notch regulation.
Title: putzig is required for cell proliferation and regulates notch activity in Drosophila.
involved in the higher-order structuring of chromosomes
Title: Identification of the Drosophila interband-specific protein Z4 as a DNA-binding zinc-finger protein determining chromosomal structure.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ecdysone receptor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome interband	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: putzig

Names: CG7752-PA; CG7752-PB; Z4; pzg-PA; pzg-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

21286099..21290310

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_141040.2 → NP_649297.1 putzig, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649297.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VP57

Related

FBpp0077992

Conserved Domains (4) summary

sd00017
Location:360 → 380

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:268 → 289

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:373 → 399

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:375 → 443

zf-C2H2_8; C2H2-type zinc ribbon
NM_001275214.1 → NP_001262143.1 putzig, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262143.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VP57

Conserved Domains (4) summary

sd00017
Location:360 → 380

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:268 → 289

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:373 → 399

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:375 → 443

zf-C2H2_8; C2H2-type zinc ribbon