Mps1 Monopolar spindle 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mps1provided by FlyBase
Official Full Name: Monopolar spindle 1provided by FlyBase
Primary source: FLYBASE:FBgn0000063
Locus tag: Dmel_CG7643
See related: AllianceGenome:FB:FBgn0000063
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ald; Ald; Ald/Mps1; CG7643; Dmel\CG7643; dMps1; mps1; Msp1; TKK
Summary: Enables protein serine/threonine/tyrosine kinase activity. Involved in several processes, including male germ-line stem cell asymmetric division; meiotic nuclear division; and negative regulation of metaphase/anaphase transition of cell cycle. Located in centrosome; kinetochore; and spindle. Part of outer kinetochore. Is expressed in several structures, including central nervous system; extended germ band embryo; and oocyte. Orthologous to human TTK (TTK protein kinase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 90C1-90C1; 3-61 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (17671271..17673828)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (13496993..13499550)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation.
Title: Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation.
Here the authors show in vitro and in Drosophila that Protein Phosphatase 1 (PP1) inactivates Mps1 by dephosphorylating its T-loop. PP1-mediated dephosphorylation of Mps1 occurs at kinetochores and in the cytosol, and inactivation of both pools of Mps1 during metaphase is essential to ensure prompt and efficient Spindle Assembly Checkpoint silencing.
Title: Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing.
a model in which Polo controls Mps1-dependent BubR1 phosphorylation to promote Cdc20 kinetochore recruitment and sustained SAC function.
Title: Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation.
Kinetochore localized Mad2 and Cdc20 is itself insufficient for triggering the mitotic checkpoint when Mps1 is low in Drosophila melanogaster neuroblasts.
Title: Kinetochore localized Mad2 and Cdc20 is itself insufficient for triggering the mitotic checkpoint when Mps1 is low in Drosophila melanogaster neuroblasts.
Data indicate kinase activity seems to be required for Mps1 kinetochore localization.
Title: Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1.
mps1 and polo are sequestered to collagenase-sensitive filaments in Drosophila prometaphase oocytes under hypoxic conditions
Title: Hypoxia transiently sequesters mps1 and polo to collagenase-sensitive filaments in Drosophila prometaphase oocytes.
oocytes lacking Ald/Mps1 protein enter anaphase I immediately upon completing spindle formation, in a fashion that does not allow sufficient time for nonexchange homologs to complete their normal partitioning to opposite half spindles
Title: The multiple roles of mps1 in Drosophila female meiosis.
Mps1 is required for the arrest of cell cycle progression in response to hypoxia
Title: The mitotic arrest in response to hypoxia and of polar bodies during early embryogenesis requires Drosophila Mps1.
Mps1 plays an important role in Drosophila female meiosis by regulating processes that are especially critical for ensuring the proper segregation of nonexchange chromosomes.
Title: The meiotic defects of mutants in the Drosophila mps1 gene reveal a critical role of Mps1 in the segregation of achiasmate homologs.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1684 (e-PCR)
- UniSTS:34599

Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine/tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine/tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in achiasmate meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in distributive segregation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in distributive segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female meiosis chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germ-line stem cell asymmetric division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic metaphase I homologous chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic spindle assembly checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic spindle checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly checkpoint signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization to kinetochore	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of outer kinetochore	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: monopolar spindle 1

Names: CG7643-PA; CG7643-PB; Mps1-PA; Mps1-PB; altered disjunction; monopolar spindles 1

NP_001262677.1

EC 2.7.11.1

EC 2.7.12.1

NP_650644.1

EC 2.7.11.1

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

17671271..17673828

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275748.1 → NP_001262677.1 monopolar spindle 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262677.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KG66

Conserved Domains (2) summary

smart00220
Location:337 → 575

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14131
Location:335 → 579

PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
NM_142387.3 → NP_650644.1 monopolar spindle 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650644.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VEH1

Related

FBpp0082911

Conserved Domains (2) summary

smart00220
Location:337 → 611

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14131
Location:335 → 612

PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)