Official Symbol

UBA5provided by HGNC

Official Full Name

ubiquitin-like modifier activating enzyme 5provided by HGNC

Primary Source

HGNC:23230

See related

Ensembl:ENSG00000081307; HPRD:15598; MIM:610552

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

THIFP1; UBE1DC1; FLJ17281; FLJ23251; FLJ23251UBA5; UBA5

Summary

This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A pseudogene located on chromosome 1 has also been identified. [provided by RefSeq]

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Preferred Names

ubiquitin-activating enzyme 5

Names

ubiquitin-activating enzyme 5

UFM1-activating enzyme

UBA5, ubiquitin-activating enzyme E1 homolog

ubiquitin-activating enzyme E1-domain containing 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_024818.3 → NP_079094.1  ubiquitin-activating enzyme 5 isoform 1

   Description

   Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

   Source sequence(s)

   AY253672,BQ581736,DB082596

   Consensus CDS

   CCDS3076.1

   UniProtKB/Swiss-Prot

   Q9GZZ9

   Conserved Domains (2) summary

   cd00757
   Location:52 – 297
   Blast Score: 524

   ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...

   TIGR02356
   Location:53 – 273
   Blast Score: 240

   adenyl_thiF; thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily

2. NM_198329.2 → NP_938143.1  ubiquitin-activating enzyme 5 isoform 2

   Description

   Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream start codon, as compared to variant 1. The encoded isoform (2) is thus shorter at the N-terminus, as compared to isoform 1.

   Source sequence(s)

   AY253672,BQ581736,DB457433

   Consensus CDS

   CCDS3077.1

   UniProtKB/TrEMBL

   A6NJL3

   UniProtKB/Swiss-Prot

   Q9GZZ9

   Conserved Domains (2) summary

   cd00757
   Location:1 – 241
   Blast Score: 505

   ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...

   TIGR02356
   Location:1 – 217
   Blast Score: 228

   adenyl_thiF; thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

1. NC_000003.11

   Range

   132373289..132396943

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NT_005612.16 

   Range

   38868435..38892089

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

1. AC_000046.1

   Range

   130798782..130822432

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_921807.1 

   Range

   38984452..39008102

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

1. AC_000135.1

   Range

   129753022..129776586, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_001838884.2 

   Range

   61652444..61676008, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)