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    ZNF354A zinc finger protein 354A [ Homo sapiens (human) ]

    Gene ID: 6940, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF354Aprovided by HGNC
    Official Full Name
    zinc finger protein 354Aprovided by HGNC
    Primary source
    HGNC:HGNC:11628
    See related
    Ensembl:ENSG00000169131 MIM:602444; AllianceGenome:HGNC:11628
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EZNF; HKL1; KID1; KID-1; TCF17; HEL104
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol; nucleolus; and nucleoplasm. Biomarker of in situ carcinoma and seminoma. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 5.1), thyroid (RPKM 4.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    5q35.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (178711512..178730659, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (179263543..179282761, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (178138513..178157660, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene vomeronasal 2 receptor 2 pseudogene Neighboring gene Myb/SANT DNA binding domain containing 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:178150344-178150844 Neighboring gene MPRA-validated peak5604 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16723 Neighboring gene acetoacetyl-CoA synthetase pseudogene 1 Neighboring gene CRISPRi-validated cis-regulatory element chr5.4957 Neighboring gene Sharpr-MPRA regulatory region 5461 Neighboring gene coiled-coil domain containing 86 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The tcf17 gene at chromosome 5q is not involved in the development of conventional renal cell carcinoma. Bugert P, et al. Int J Cancer, 2000 Jun 15. PMID 10842194
    2. Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1. Omori Y, et al. Cytogenet Cell Genet, 1997. PMID 9465904
    3. Molecular cloning of a zinc finger gene eZNF from a human inner ear cDNA library, and in situ expression pattern of its mouse homologue in mouse inner ear. Jacob AN, et al. Somat Cell Mol Genet, 1998 Mar. PMID 9919311
    4. Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury. Witzgall R, et al. Mol Cell Biol, 1993 Mar. PMID 8382778, Free PMC Article
    5. A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. Kim SS, et al. Proc Natl Acad Sci U S A, 1996 Dec 24. PMID 8986806, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Meta-analysis of gene-disease association. (HuGE Navigator)
      Title: Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 354A (ZNF354A; TCF17) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
    Knockdown of zinc finger protein 354A (ZNF354A; TCF17) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 354A
    Names
    epididymis luminal protein 104
    transcription factor 17
    zinc finger protein eZNF

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324339.2 → NP_001311268.1  zinc finger protein 354A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113348, EU794664
      UniProtKB/TrEMBL
      V9HWI2
      Conserved Domains (3) summary
      COG5048
      Location:156 → 558
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:454 → 474
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:326 → 351
      zf-H2C2_2; Zinc-finger double domain

    2. NM_005649.3 → NP_005640.2  zinc finger protein 354A isoform 1

      See identical proteins and their annotated locations for NP_005640.2

      Status: VALIDATED

      Source sequence(s)
      AC113348, AF116030, BC036517, BU685427
      Consensus CDS
      CCDS4438.1
      UniProtKB/Swiss-Prot
      O60765, Q9UNJ8
      UniProtKB/TrEMBL
      V9HWI2
      Related
      ENSP00000337122.2, ENST00000335815.7
      Conserved Domains (5) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:198 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:496 → 516
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:368 → 393
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      178711512..178730659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009791.2 → XP_016865280.1  zinc finger protein 354A isoform X1

      UniProtKB/Swiss-Prot
      O60765, Q9UNJ8
      UniProtKB/TrEMBL
      V9HWI2
      Conserved Domains (5) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:198 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:496 → 516
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:368 → 393
      zf-H2C2_2; Zinc-finger double domain

    2. XM_047417644.1 → XP_047273600.1  zinc finger protein 354A isoform X1

      UniProtKB/Swiss-Prot
      O60765, Q9UNJ8
      UniProtKB/TrEMBL
      V9HWI2

    3. XM_011534645.3 → XP_011532947.1  zinc finger protein 354A isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:156 → 558
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:454 → 474
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:326 → 351
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      179263543..179282761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353337.1 → XP_054209312.1  zinc finger protein 354A isoform X1

      UniProtKB/Swiss-Prot
      O60765, Q9UNJ8
      UniProtKB/TrEMBL
      V9HWI2

    2. XM_054353338.1 → XP_054209313.1  zinc finger protein 354A isoform X1

      UniProtKB/Swiss-Prot
      O60765, Q9UNJ8
      UniProtKB/TrEMBL
      V9HWI2

    3. XM_054353339.1 → XP_054209314.1  zinc finger protein 354A isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60765.2 GenPept UniProtKB/Swiss-Prot:O60765

    Gene LinkOut

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