Krt6c keratin 6c [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Krt6cprovided by RGD
Official Full Name: keratin 6cprovided by RGD
Primary source: RGD:1588056
See related: Ensembl:ENSRNOG00000070470 AllianceGenome:RGD:1588056
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CK-6A; Krt6a
Summary: Predicted to be involved in morphogenesis of an epithelium and wound healing. Predicted to be located in keratin filament. Human ortholog(s) of this gene implicated in pachyonychia congenita. Orthologous to human KRT6A (keratin 6A) and KRT6B (keratin 6B). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7q36

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (134678316..134682753, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (132799608..132804045, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

BI289674 (e-PCR)
- UniSTS:246877

RH131737 (e-PCR)
- UniSTS:215020

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intermediate filament cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info
involved_in morphogenesis of an epithelium	ISS Inferred from Sequence or Structural Similarity more info
involved_in wound healing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: keratin, type II cytoskeletal 6A

Names: K6a keratin; cytokeratin-6A; keratin K6; keratin, type II cytoskeletal 5; keratin, type II cytoskeletal 5-like; type-II keratin Kb6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001101007.1 → NP_001094477.1 keratin, type II cytoskeletal 6A

See identical proteins and their annotated locations for NP_001094477.1

Status: PROVISIONAL

Source sequence(s)

BC099121

UniProtKB/Swiss-Prot

Q4FZU2

Related

ENSRNOP00000087976.1, ENSRNOT00000102479.1

Conserved Domains (3) summary

pfam00038
Location:151 → 464

Filament; Intermediate filament protein

pfam16208
Location:15 → 148

Keratin_2_head; Keratin type II head

cl01888
Location:377 → 437

DUF883; Bacterial protein of unknown function (DUF883)