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Studies suggest that Hh binding to Ptc leads to the de-repression of the GPCR-related protein Smo. |
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the expression of Smoothened was very low or almost absent In the normal endometrium and significantly highly expressed in complex and atypical hyperplasia |
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The interactions of small molecule agonists and antagonists with SMO were characterized. |
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4. |
Observational study of gene-disease association. (HuGE Navigator) |
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Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
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Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
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Constitutive activation of the hedgehog signaling pathway in chondrosarcoma is rarely caused by SMO protein mutation. |
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8. |
mutations are rare in SMO in sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumors |
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Smo mutants augment p53 binding to the E3 ubiquitin-protein ligase Mdm2 and promote p53 ubiquitination. |
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10. |
Significantly high levels of ultraviolet-specific mutations in the smoothened gene are found in basal cell carcinomas from DNA repair-deficient xeroderma pigmentosum patients. |
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11. |
beta-Arrestin 2 and GRK2 are potential mediators of signaling by activated Smoothened |
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12. |
the upstream part of the Hedgehog pathway involving Hedgehog interaction with Patched, regulation of Smoothened by Patched, and Smoothened enrichment at the plasma membrane is highly conserved between Drosophila and humans |
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13. |
results suggest that the Ptc tumour suppressor functions normally as a transmembrane molecular transporter, which acts indirectly to inhibit Smo activity |
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14. |
aberrant expressions of PTCH and Smo were common in pancreatic carcinoma tissues & were associated with low-level differentiation of tumor tissue & hyperglycemia; this indicated that these molecules played a fundamental role in pancreas tumorigenesis |
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15. |
overexpression and/or tumorigenic activation of the Smo proto-oncogene mediates c-myc overexpression which plays a critical role in hepatocarcinogenesis; study suggests that Smo is a prognostic factor in HCC tumorigenesis |
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16. |
smoothened expression in human astrocytic tumors inversely correlates with histological malignancy |
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17. |
role of the human M2SMO mutant in BCC development in adult transgenic mice |
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18. |
analysis of Hedgehog modulator properties after functional coupling of Smoothened to G15 |