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1. |
A missense polymorphism (rs2296212)induced a lower nuclear localization of BRM was associated with low SMARCA2 expression in the postmortem prefrontal cortex of schizophrenia patients. |
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2. |
Loss of heterozygosity at the 9p21-24 region and identification of BRM as a candidate tumor suppressor gene in head and neck squamous cell carcinoma. |
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3. |
Cdx2 regulates intestinal villin expression through recruiting Brm-type SWI/SNF complex to the villin promoter. |
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4. |
BRM and BRG1 SWI/SNF complexes have roles in differentiation |
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5. |
Hotspot mutation of Brahma in non-melanoma skin cancer. |
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6. |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
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at the TERT gene locus in human tumour cells containing a functional SWI/SNF complex, Brm, and possibly BRG1, in concert with p54(nrb), would initiate efficient transcription and could be involved in the subsequent splicing of TERT transcripts |
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8. |
Observational study of gene-disease association. (HuGE Navigator) |
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9. |
p53 activity is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes |
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10. |
C/EBPbeta and GATAs may developmentally regulate the expression of brm by mutually exclusive binding. |
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11. |
Brm is required for villin expression, a definitive marker of intestinal metaplasia and differentiation |
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12. |
Loss of BRM through epigenetic silencing is associated with neoplasms |
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13. |
Brm-containing SWI/SNF complex subfamily (trithorax-G) and a complex including YY1 and HDACs (Polycomb-G) counteract each other to maintain transcription of exogenously introduced genes |
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14. |
Cell culture in the presence of HDAC inhibitors facilitates the isolation of clones overexpressing Brm. |
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15. |
This report provides supportive evidence that BRG1 and BRM act as tumor suppressor proteins and implicates a role for their loss in the development of non-small cell lung cancers. |
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16. |
BRM and BRG1 participate in two distinct chromosome remodeling complexes that are functionally complementary in non-small cell lung cancer |
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17. |
Brm could also drive expression of CD44; Brm can compensate for BRG-1 loss as pertains to RB sensitivity |
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18. |
on genes regulated by SWI/SNF, Brm contributes to the crosstalk between transcription and RNA processing by decreasing RNAPII elongation rate and facilitating recruitment of the splicing machinery to variant exons with suboptimal splice sites |
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19. |
family-based and case-control association study suggest that there is no association between the trinucleotide repeat polymorphism within SMARCA2 and schizophrenia |
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20. |
Aberrant expression of BRM genes is associated with disease development and progression in prostate cancers. |
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21. |
BRG1 and BRM complexes may direct distinct cellular processes by recruitment to specific promoters through protein-protein interactions that are unique to each ATPase. |
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22. |
human adrenal carcinoma cells can spontaneously transition between two subtypes by switching expression of BRG1 and Brm at the post-transcriptional level |