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1. |
Advanced osteoarthritis is associated with altered collagen VI expression and upregulation of ER-stress markers Grp78 and bag-1. |
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2. |
The results of our study showed that overall cytoplasmic and nuclear BAG-1 expression and overall and cytoplasmic CD24 expression, correlates with adverse prognostic parameters for breast carcinoma. |
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3. |
These findings indicate a novel mechanism by which Bag-1M acts as a corepressor and downregulates the activity of the glucocorticoid receptor. |
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4. |
we report a specific increase of BAG-1M in human Alzheimer's disease patients |
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5. |
BAG-1 inhibits the transactivating functions of p73 and provide new insight into the mechanisms that control the expression of p73. |
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6. |
Distinct isoforms of BAG-1 have different anti-apoptotic functions in breast cancer cells, and that the BAG-1 p50 isoform can potentiate the role of estrogen in ER-positive breast cancer. |
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7. |
Gene expression revealed up-regulation of pro-angiogenic (PGF), anti-apoptotics (BAG-1, BCL-2), heart development (TNNT2, TNNC1) and extracellular matrix remodelling (MMP-2, MMP-7) genes in SM. |
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8. |
BAG-1 protein was deregulated in this disease similar to some other malignancies such as breast and colon cancer |
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9. |
A high BAG-1 expression predicts improved patient outcome in estrogen receptor-positive breast carcinoma. |
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10. |
Bag1 NEF increased refolding by Hsc70 and DJA2, as did the newly characterized NEF Hsp110 |
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11. |
These findings identify a regulatory mechanism, downstream of hormone binding, used by Bag-1M for attenuating GR action in response to its changing cellular levels. |
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12. |
Bag-1 expression in breast tumors is associated with improved outcome and steroid receptor positivity. |
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13. |
Chromatin immunoprecipitation analysis of the BAG-1 promoter in DNMT1-overexpressing or DNMT3B-overexpressing colon cells show a permissive chromatin status assoscsiated with DNA binding of BORIS. |
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14. |
By inhibiting NF-kappaB, suppression of BAG-1 could represent a novel strategy to impede colorectal cancer cell survival and as an adjuvant increase sensitivity to current therapeutic regimes. |
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15. |
Modulation of Bag-1 expression can therefore mediate chondrocyte differentiation and turnover |
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16. |
Observational study of gene-disease association. (HuGE Navigator) |
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17. |
BAG-1 mRNA internal ribosome entry segment maintains synthesis of BAG-1 protein following exposure of cells to the chemotoxic drug vincristine but not to cisplatin. |
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18. |
BAG-1 associates with Tau protein in an Hsc70-dependent manner. |
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19. |
Results suggest that BAG-1 is able to potentiate vitamin D receptor-mediated transactivation by acting as a nuclear chaperone for 1,25(OH)2D3. |
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20. |
BAG-1L endogenously regulates gene expression by potentiating nuclear hormone receptor function and a role for BAG-1L in 24-hydroxylase regulation of vitamin D metabolism and the cellular response of oral keratinocytes to 1alpha,25-dihydroxyvitamin D3. |
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21. |
over-expression of BAG1 may play an important role in genesis and development of colon carcinoma |
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22. |
An antiapoptotic protein, BAG-1, was found to be down-regulated in chewing-tobacco-mediated tongue carcinogenesis. |
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23. |
BAG-1, an anti-apoptotic tumour marker Review |
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24. |
BAG-1-mediated resistance to stress-induced growth inhibition is likely to have a major impact on the development and response to therapy of breast cancer. |
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25. |
Increased cytosolic and nuclear BAG-1 expression may denote more aggressive variants of prostate cancer. |
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26. |
BAG-1 may promote colorectal tumour cell survival by making colonic epithelial cells less sensitive to DNA damage. |
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27. |
BAG1 activates Hsp70, which is important for neuroprotectivity. |
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28. |
The results of this study implicate BAG-1 p29 in the regulation of both the EGF signaling cascade and the apoptotic cascade induced by loss of anchorage. |
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29. |
In astrocytic tumours low ERbeta expression correlated significantly with high grade, higher expression of cytoplasmic BAG-1 and worse survival. |
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30. |
BAG-1 contributes an important cellular function to breast epithelial cells, which is reflected by its ubiquitous expression in these tissues, but does not appear to determine response to doxorubicin-based chemotherapy |
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31. |
Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor |
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32. |
BAG-1 expression inhibits apoptosis in colorectal adenoma-derived epithelial cells |
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33. |
Our experiments suggest that BAG-1 inhibits anti-cancer drug-induced apoptosis through apoptosis regulation pathways that may involve the mitochondrial Bcl-2/Bax ratio, p53, and differential anti-cancer drug-mediated cytochrome c release. |
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34. |
BAG-1 may function to suppress the GADD34-mediated cellular stress response and have a role in the survival of cells undergoing stress |
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35. |
BAG-1 is targeted to the COPI coated structures, implying its contribution toward the COPI vesicular transport in gastrointestinal epithelial cells |
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36. |
BAG-1 protein showed distinct distribution pattern in hyperplastic and neoplastic prostate. BAG-1 with BCL-2 inhibits apoptosis and may prolong the life of neoplastic cells and give them a chance to gain new oncogenic features in early carcinogenesis. |
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37. |
P. 130:..."[h]igh expression of Bcl-2", was one of the predictive factors "for achievement of pathological remission after preoperative chemotherapy" containing anthracycline. |
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38. |
BAG-1 is expressed in the endometrium. High-grade cancers stain more frequently than secretory endometrium for both cytoplasmic and nuclear BAG-1 expression, perhaps indicating an association between expression of BAG-1 and prognosis. |
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39. |
This is the molecular basis for their effects (Hap50/BAG-1L) on transcriptional activities, which are emphasized in this review and for which a molecular model is presented. |
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40. |
Recombinant BAG-1 can influence cellular response to stress in cardiomyocytes by multiple mechanisms, potentially influenced by the cell type and nature of the stress signal. |
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41. |
nuclear BAG-1 expression is a useful predictive factor for distant metastasis and a poor prognosis in patients with colorectal cancer. |
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42. |
a secondary structural model of the Bag-1 IRES has been derived by using chemical and enzymatic probing data as constraints on the RNA folding algorithm Mfold |
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43. |
The longer p50 isoform is generated through the use of an upstream, in-frame, non-AUG (CUG) translation initiation codon. |
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44. |
Alternate protein isoforms arise through the use of a non-AUG (CUG) codon in addition to downstream in-frame AUG codons. |