IFNW1 interferon omega 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: IFNW1provided by CGNC
Full Name: interferon omega 1provided by CGNC
Primary source: CGNC:54342
See related: Ensembl:ENSGALG00010012349
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: IFN2; IFNB; IFN_B; IFN-beta
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Genomic context

Location:: chromosome: Z

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	Z	NC_052572.1 (7819384..7820576)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	Z	NC_059536.1 (7819384..7820576)

Chromosome Z - NC_052572.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DEAD/DEAH-box helicase 5 is hijacked by an avian oncogenic herpesvirus to inhibit interferon beta production and promote viral replication.
Title: DEAD/DEAH-box helicase 5 is hijacked by an avian oncogenic herpesvirus to inhibit interferon beta production and promote viral replication.
These results indicate that duRIG-I CARD domain plays an important role in the induction of IFN-b and provide a basis for further studying the function of RIG-I in avian innate immunity
Title: Duck RIG-I CARD Domain Induces the Chicken IFN-β by Activating NF-κB.
Data indicate that the expression levels of chick fibroblast DF-1 interferon beta (IFN-beta) and myxovirus resistance-1 (Mx1) mRNA were down-regulated by over-expression of duck albumin (ALB) gene.
Title: [Ectopic expression of duck albumin down-regulates the expressions of IFN-β and myxovirus resistance 1 mRNA in DF-1 cells].
Overexpression of TLR3 enhanced the activity of the IFN-beta promoter and the transcription factor NF-kappa B, thereby decreasing viral protein synthesis.
Title: Toll-like receptor 3 inhibits Newcastle disease virus replication through activation of pro-inflammatory cytokines and the type-1 interferon pathway.
Fpv012 inhibits induction of IFNB.
Title: Genetic screen of a mutant poxvirus library identifies an ankyrin repeat protein involved in blocking induction of avian type I interferon.
RNA interference-mediated knockdown of ChMda5 showed that ChMda5 plays an important role in the IFN response of chicken cells to dsRNA
Title: Characterization of chicken Mda5 activity: regulation of IFN-β in the absence of RIG-I functionality.
study observed an upregulation in the expression of both TLR3 and IFNbeta during H5N1 infection in chickens; findings show that poly(I:C)-stimulated IFNbeta expression involves TLR3 signalling
Title: Activation of the TLR3 pathway regulates IFNbeta production in chickens.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables type I interferon receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in B cell proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in T cell activation involved in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in humoral immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in natural killer cell activation involved in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to exogenous dsRNA	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interferon type B

Names: interferon, beta 1, fibroblast; interferon-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024836.2 → NP_001020007.1 interferon type B precursor

See identical proteins and their annotated locations for NP_001020007.1

Status: VALIDATED

Source sequence(s)

JAENSK010000086

UniProtKB/Swiss-Prot

Q4Z8K4, Q90873

UniProtKB/TrEMBL

D1M7B2, Q5MFU9

Related

ENSGALP00010017190.1, ENSGALT00010029563.1

Conserved Domains (1) summary

cd00095
Location:31 → 180

IFab; Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several ...