Avpr1a arginine vasopressin receptor 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Avpr1aprovided by MGI
Official Full Name: arginine vasopressin receptor 1Aprovided by MGI
Primary source: MGI:MGI:1859216
See related: Ensembl:ENSMUSG00000020123 AllianceGenome:MGI:1859216
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: V1a; AVPR; V1aR; Avpr1
Summary: This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues [provided by RefSeq, Jul 2008]
Expression: Biased expression in liver adult (RPKM 15.9), bladder adult (RPKM 11.1) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D2; 10 70.36 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (122284404..122289358)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (122448499..122453453)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vasopressin receptor 1a, oxytocin receptor, and oxytocin knockout male and female mice display normal perceptual abilities towards non-social odorants.
Title: Vasopressin receptor 1a, oxytocin receptor, and oxytocin knockout male and female mice display normal perceptual abilities towards non-social odorants.
Vasopressin V1a receptor and oxytocin receptor regulate murine sperm motility differently.
Title: Vasopressin V1a receptor and oxytocin receptor regulate murine sperm motility differently.
Activation of V1a vasopressin receptors excite subicular pyramidal neurons by activating TRPV1 and depressing GIRK channels.
Title: Activation of V(1a) vasopressin receptors excite subicular pyramidal neurons by activating TRPV1 and depressing GIRK channels.
Critical role of V1a vasopressin receptor in murine parturitiondagger.
Title: Critical role of V1a vasopressin receptor in murine parturition†.
Vasopressin V1a Receptors Regulate Cerebral Aquaporin 1 after Traumatic Brain Injury.
Title: Vasopressin V(1a) Receptors Regulate Cerebral Aquaporin 1 after Traumatic Brain Injury.
Subtle sex differences in vasopressin mRNA expression in the embryonic mouse brain.
Title: Subtle sex differences in vasopressin mRNA expression in the embryonic mouse brain.
sympathetic vasomotor control by spinal AT1 and V1a receptors in the acute phase of hemorrhagic shock
Title: Differential sympathetic vasomotor control by spinal AT(1) and V1a receptors in the acute phase of hemorrhagic shock.
No difference between wild-type (WT) and v1a and v1b double knockout (dKO) mice was found in olfactory preferences for estrous female odor to male odor. Over all four mating tests, the number of mounts and pursuits after receptive females was significantly greater in dKO mice than in WT mice. In the elevated plus maze and the open field test, dKO mice showed lower anxiety-like behavior than WT mice.
Title: Modulation of male mouse sociosexual and anxiety-like behaviors by vasopressin receptors.
mice experiencing early beneficial and later adverse conditions showed a most pronounced downregulation of Avpr1a expression, accompanied by low anxiety-like behaviour.
Title: Impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice.
depressive-like behavior alters oxytocin receptor (OxtR) and arginine vasopressin receptor type 1a (AvpR1a) gene expression in the hippocampus (HC) of male mice.
Title: Chronic Postnatal Stress Induces Depressive-like Behavior in Male Mice and Programs second-Hit Stress-Induced Gene Expression Patterns of OxtR and AvpR1a in Adulthood.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (4)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables V1A vasopressin receptor binding	ISO Inferred from Sequence Orthology more info
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables vasopressin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vasopressin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in grooming behavior	ISO Inferred from Sequence Orthology more info
involved_in maternal aggressive behavior	ISO Inferred from Sequence Orthology more info
involved_in maternal behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of female receptivity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular pH reduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of systemic arterial blood pressure by vasopressin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of systemic arterial blood pressure by vasopressin	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to inorganic substance	ISO Inferred from Sequence Orthology more info
involved_in response to organic substance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in sperm ejaculation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vasopressin V1a receptor

Names: AVPR V1a; V1a arginine vasopressin receptor; antidiuretic hormone receptor 1a; vascular/hepatic-type arginine vasopressin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016847.2 → NP_058543.2 vasopressin V1a receptor

See identical proteins and their annotated locations for NP_058543.2

Status: REVIEWED

Source sequence(s)

D49730

Consensus CDS

CCDS24215.1

UniProtKB/Swiss-Prot

Q62463, Q62464, Q9QYH2

UniProtKB/TrEMBL

Q3U1H9, Q3UEE1

Related

ENSMUSP00000020323.6, ENSMUST00000020323.7

Conserved Domains (3) summary

pfam00001
Location:68 → 353

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam08983
Location:377 → 423

DUF1856; Domain of unknown function (DUF1856)

cl21561
Location:62 → 259

7tm_4; Olfactory receptor