U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    LYN LYN proto-oncogene, Src family tyrosine kinase [ Bos taurus (cattle) ]

    Gene ID: 534996, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    LYNprovided by VGNC
    Official Full Name
    LYN proto-oncogene, Src family tyrosine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:31098
    See related
    BGD:BT22135; Ensembl:ENSBTAG00000020034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 14
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (23135370..23244752)

    Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 68 Neighboring gene trimethylguanosine synthase 1 Neighboring gene small nucleolar RNA U54 Neighboring gene U1 spliceosomal RNA Neighboring gene ribosomal protein S20

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    tyrosine-protein kinase Lyn
    Names
    v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    NP_001171211.2
    XP_024857406.1
    XP_024857407.1
    XP_059749282.1
    XP_059749283.1
    XP_059749284.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177740.2 → NP_001171211.2  tyrosine-protein kinase Lyn

      Status: VALIDATED

      Source sequence(s)
      EH373958, EV733272, NKLS02000014
      UniProtKB/TrEMBL
      D4QGC1, D6RVQ8, F1N261
      Related
      ENSBTAP00000026686.5, ENSBTAT00000026686.6
      Conserved Domains (3) summary
      cd10364
      Location:125 → 225
      SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
      cd12004
      Location:67 → 122
      SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
      cd05072
      Location:239 → 510
      PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      23135370..23244752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059893299.1 → XP_059749282.1  tyrosine-protein kinase Lyn isoform X1

      UniProtKB/TrEMBL
      F1N261

    2. XM_059893301.1 → XP_059749284.1  tyrosine-protein kinase Lyn isoform X2

    3. XM_059893300.1 → XP_059749283.1  tyrosine-protein kinase Lyn isoform X1

      UniProtKB/TrEMBL
      F1N261

    4. XM_025001638.2 → XP_024857406.1  tyrosine-protein kinase Lyn isoform X1

      UniProtKB/TrEMBL
      D4QGC1, D6RVQ8, F1N261
      Conserved Domains (3) summary
      cd10364
      Location:125 → 225
      SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
      cd12004
      Location:67 → 122
      SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
      cd05072
      Location:239 → 510
      PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

    5. XM_025001639.2 → XP_024857407.1  tyrosine-protein kinase Lyn isoform X2

      UniProtKB/TrEMBL
      D4QGC1, D6RVQ8
      Conserved Domains (3) summary
      cd10364
      Location:104 → 204
      SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
      cd12004
      Location:46 → 101
      SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
      cd05072
      Location:218 → 489
      PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous