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    NLK nemo like kinase [ Homo sapiens (human) ]

    Gene ID: 51701, updated on 3-Apr-2024

    Summary

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    Official Symbol
    NLKprovided by HGNC
    Official Full Name
    nemo like kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:29858
    See related
    Ensembl:ENSG00000087095 MIM:609476; AllianceGenome:HGNC:29858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in protein stabilization and transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 18.0), adrenal (RPKM 18.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NLK in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (28042677..28206074)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (28984080..29146552)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26369703..26523407)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:26360641-26361840 Neighboring gene uncharacterized LOC105371709 Neighboring gene Sharpr-MPRA regulatory region 3957 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8332 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8333 Neighboring gene uncharacterized LOC102724517 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11917 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11918 Neighboring gene NANOG hESC enhancer GRCh37_chr17:26440640-26441141 Neighboring gene ribosomal protein S29 pseudogene 22 Neighboring gene uncharacterized LOC105371711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11919 Neighboring gene uncharacterized LOC105371710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:26553198-26553848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:26554499-26555148 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:26555149-26555798 Neighboring gene Sharpr-MPRA regulatory region 13006 Neighboring gene uncharacterized LOC105371712 Neighboring gene peptide YY 2 (pseudogene) Neighboring gene pancreatic polypeptide 2, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Knockdown of Nemo‑like kinase promotes metastasis in non‑small‑cell lung cancer. Shi C, et al. Oncol Rep, 2019 Sep. PMID 31322229, Free PMC Article
    2. Overexpression of Nemo-like Kinase Promotes the Proliferation and Invasion of Lung Cancer Cells and Indicates Poor Prognosis. Lei L, et al. Curr Cancer Drug Targets, 2019. PMID 30451112
    3. NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Yuan HX, et al. Genes Dev, 2015 Nov 15. PMID 26588989, Free PMC Article
    4. NLK functions to maintain proliferation and stemness of NSCLC and is a target of metformin. Suwei D, et al. J Hematol Oncol, 2015 Oct 26. PMID 26503334, Free PMC Article
    5. The emerging role of Nemo-like kinase (NLK) in the regulation of cancers. Huang Y, et al. Tumour Biol, 2015 Dec. PMID 26427665

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration.
      Title: Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration.
    2. Somatic Mutations and Intratumoral Heterogeneity of Cancer-Related Genes NLK, YY1 and PA2G4 in Gastric and Colorectal Cancers.
      Title: Somatic Mutations and Intratumoral Heterogeneity of Cancer-Related Genes NLK, YY1 and PA2G4 in Gastric and Colorectal Cancers.
    3. NLK interacts with 1433zeta to restore the expression of Ecadherin.
      Title: NLK interacts with 14‑3‑3ζ to restore the expression of E‑cadherin.
    4. Effect of NLK on the proliferation and invasion of laryngeal carcinoma cells by regulating CDCP1.
      Title: Effect of NLK on the proliferation and invasion of laryngeal carcinoma cells by regulating CDCP1.
    5. Overexpression of Nemo-like Kinase Promotes the Proliferation and Invasion of Lung Cancer Cells and Indicates Poor Prognosis.
      Title: Overexpression of Nemo-like Kinase Promotes the Proliferation and Invasion of Lung Cancer Cells and Indicates Poor Prognosis.
    6. Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.
      Title: Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.
    7. Low NLK expression is associated with metastasis in nonsmallcell lung cancer.
      Title: Knockdown of Nemo‑like kinase promotes metastasis in non‑small‑cell lung cancer.
    8. Nemo like kinase (NLK) interacts with and phosphorylates mitochondrial antiviral signaling protein (MAVS), and a peptide derived from MAVS promotes viral-induced interferon beta (IFN-beta) production and antagonizes viral replication.
      Title: Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response.
    9. NLK boosts cell proliferation and E2F1 activity and controls the cell cycle switch by releasing HDAC1 from the E2F1 complex, us priming colorectal cancer progression
      Title: Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1.
    10. the promoters of WIF1, NLK, and APC are highly methylated in the nasopharyngeal cancers (NPC) and gastric carcinoma (GC) cell lines, and the 3 genes are also regulated by miR-BART19-3p expressed by Epstein-Barr virus (EBV); expression of the WIF1, APC, and NLK genes is strongly affected by hypermethylation, and in EBV-associated tumors, the 3 genes are also affected by miR-BART19-3p
      Title: The effect of EBV on WIF1, NLK, and APC gene methylation and expression in gastric carcinoma and nasopharyngeal cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (55)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu In vitro protein-protein interaction analysis identifies a Vpu-binding host protein nemo-like kinase (NLK) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21033, DKFZp761G1211

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables SH2 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Wnt signaling pathway, calcium modulating pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in cellular response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of TORC1 signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-threonine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in serine phosphorylation of STAT protein ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase NLK
    NP_057315.3
    XP_005258045.1
    XP_054172389.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016231.5 → NP_057315.3  serine/threonine-protein kinase NLK

      See identical proteins and their annotated locations for NP_057315.3

      Status: VALIDATED

      Source sequence(s)
      AC090287, AK024686, AL036279, BM723604, BQ636970, DA224552, DA573077, U69562
      Consensus CDS
      CCDS11224.2
      UniProtKB/Swiss-Prot
      B2RCX1, Q2PNI9, Q6P2A3, Q9UBE8
      UniProtKB/TrEMBL
      H0YD75
      Related
      ENSP00000384625.3, ENST00000407008.8
      Conserved Domains (1) summary
      cd07853
      Location:137 → 508
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      28042677..28206074
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257988.3 → XP_005258045.1  serine/threonine-protein kinase NLK isoform X1

      See identical proteins and their annotated locations for XP_005258045.1

      UniProtKB/TrEMBL
      H0YD75
      Conserved Domains (1) summary
      cd07853
      Location:137 → 479
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

    RNA

    1. XR_934482.2 RNA Sequence

    2. XR_001752526.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      28984080..29146552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316414.1 → XP_054172389.1  serine/threonine-protein kinase NLK isoform X1

    RNA

    1. XR_008484832.1 RNA Sequence

    2. XR_008484833.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UBE8.2 GenPept UniProtKB/Swiss-Prot:Q9UBE8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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