Official Symbol

TUBE1provided by HGNC

Official Full Name

tubulin, epsilon 1provided by HGNC

Primary Source

HGNC:20775

Locus Tag

RP1-142L7.1

See related

Ensembl:ENSG00000074935; HPRD:06298; MIM:607345

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

TUBE; FLJ22589; FLJ44203; dJ142L7.2; TUBE1

Summary

This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.

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Preferred Names

tubulin, epsilon 1

Names

tubulin, epsilon 1

Tubulin epsilon chain

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_016262.4 → NP_057346.1  tubulin, epsilon 1

   Source sequence(s)

   AK026242,BC025405,CA411886,DA160210

   Consensus CDS

   CCDS5100.1

   UniProtKB/TrEMBL

   Q5H8W8

   UniProtKB/Swiss-Prot

   Q9UJT0

   Conserved Domains (2) summary

   COG5023
   Location:1 – 456
   Blast Score: 751

   COG5023; Tubulin [Cytoskeleton]

   cd02190
   Location:2 – 457
   Blast Score: 1793

   epsilon_tubulin; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The epsilon-tubulins which are widespread but not...

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

1. NC_000006.11

   Range

   112391859..112408750, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NT_025741.15 

   Range

   16561316..16578207, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

1. AC_000049.1

   Range

   113133161..113150057, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_923184.1 

   Range

   45201765..45218661, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

1. AC_000138.1

   Range

   109966689..109983618

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   GenBank FASTA Sequence Viewer (Graphics)

2. NW_001838990.2 

   Range

   45139279..45156208

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   GenBank FASTA Sequence Viewer (Graphics)