Mapk9 mitogen-activated protein kinase 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mapk9provided by RGD
Official Full Name: mitogen-activated protein kinase 9provided by RGD
Primary source: RGD:628847
See related: Ensembl:ENSRNOG00000002823 AllianceGenome:RGD:628847
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SAPK
Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases are multifunctional proteins. They are involved in a wide variety of cellular processes such as growth, proliferation, differentiation, transcription regulation, and development. They function in stress responses, apoptosis, inflammation and transformation. For example, this kinase plays a dominant role in mediating proliferation of lung cancer and prostate cancer cells, and in regulation of osmotic stress-induced tight junction disruption. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2012]
Expression: Biased expression in Brain (RPKM 297.8), Liver (RPKM 173.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q21

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (34670750..34711972)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (34169661..34211138)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (35333859..35374364)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Isoform-specific functions of c-Jun N-terminal kinase 1 and 2 in lung ischemia-reperfusion injury through the c-Jun/activator protein-1 pathway.
Title: Isoform-specific functions of c-Jun N-terminal kinase 1 and 2 in lung ischemia-reperfusion injury through the c-Jun/activator protein-1 pathway.
Chrysophanol Protects Against Acute Heart Failure by Inhibiting JNK1/2 Pathway in Rats.
Title: Chrysophanol Protects Against Acute Heart Failure by Inhibiting JNK1/2 Pathway in Rats.
Stathmin therefore mediates hepatocyte resistance to death from oxidative stress by down regulating JNK and maintaining mitochondrial integrity
Title: Stathmin mediates hepatocyte resistance to death from oxidative stress by down regulating JNK.
Data indicate that aluminum (Al) enhances heme oxygenase-1 (HO-1) expression through the reactive oxygen species (ROS)-JNK1/2 pathway.
Title: Heme oxygenase-1 induction by the ROS-JNK pathway plays a role in aluminum-induced anemia.
The expression of alpha-SMA was up-regulated by JNK1 and JNK2 in non-stress condition during liver fibrosis
Title: JNK1 and JNK2 regulate α-SMA in hepatic stellate cells during CCl4 -induced fibrosis in the rat liver.
JNK2 mediates survival of hepatocytes from menadione-induced cell death whereas JNK1 promotes cell death.
Title: Distinct functions of JNK and c-Jun in oxidant-induced hepatocyte death.
E(2), BSA-E(2) and ERalpha expression exert their cardioprotective effects by inhibiting JNK1/2-mediated LPS-induced TNF-alpha expression and cardiomyocyte apoptosis through activation of Akt
Title: Akt mediates 17beta-estradiol and/or estrogen receptor-alpha inhibition of LPS-induced tumor necresis factor-alpha expression and myocardial cell apoptosis by suppressing the JNK1/2-NFkappaB pathway.
The role of JNK2 in the mechanism of osmotic stress-induced tight junction disruption in the intestinal epithelium in 3 species is described.
Title: c-Jun NH2-terminal kinase-2 mediates osmotic stress-induced tight junction disruption in the intestinal epithelium.
IL-1beta stimulates GDNF release through the pathways of IkappaB-nuclear factor kappa B, p38 MAP kinase, p44/p42 MAP kinase and JAK-STAT3, but not through the SAPK/JNK pathway in glioma cells.
Title: Mechanisms of interleukin-1beta-induced GDNF release from rat glioma cells.
a balance in JNK1/2 and p38alpha activation determines the level of Ao gene expression in myocardial cells.
Title: Stretch-induced regulation of angiotensinogen gene expression in cardiac myocytes and fibroblasts: opposing roles of JNK1/2 and p38alpha MAP kinases.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables JUN kinase activity	IEA Inferred from Electronic Annotation more info
enables JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables JUN kinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
enables mitogen-activated protein kinase kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine/tyrosine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular hyperosmotic response	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amyloid-beta	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cadmium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to reactive oxygen species	IEA Inferred from Electronic Annotation more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in inflammatory response to wounding	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response to wounding	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in neuron development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production involved in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage derived foam cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric-oxide synthase biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of podosome assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of podosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of prostaglandin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein localization to tricellular tight junction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to tricellular tight junction	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to mitochondrion	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of cytochrome c from mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to amine	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nerve growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitogen-activated protein kinase 9

Names: MAP kinase 9; MAPK 9; SAPK-alpha; c-Jun N-terminal kinase 2; p54-alpha; stress activated protein kinase alpha II; stress-activated protein kinase JNK2

NP_001257473.1

EC 2.7.11.24

NP_001257474.1

EC 2.7.11.24

NP_059018.1

EC 2.7.11.24

XP_006246380.1

EC 2.7.11.24

XP_017452968.1

EC 2.7.11.24

XP_038942586.1

EC 2.7.11.24

XP_038942587.1

EC 2.7.11.24

XP_063125748.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270544.1 → NP_001257473.1 mitogen-activated protein kinase 9 isoform 2

See identical proteins and their annotated locations for NP_001257473.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate exon in the coding region, compared to variant 1. The resulting isoform (2) is of the same size, but has a different internal segment, compared to isoform 1.

Source sequence(s)

BC061870, BI282175, DN948189, JAXUCZ010000010, L27111

UniProtKB/TrEMBL

A0A0G2JYS4, A6HDY2

Related

ENSRNOP00000004010.4, ENSRNOT00000004010.5

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_001270545.1 → NP_001257474.1 mitogen-activated protein kinase 9 isoform 3

See identical proteins and their annotated locations for NP_001257474.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) is the longer transcript and has an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

BC061870, BI282175, DN948189, JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6A503, Q6P727

Related

ENSRNOP00000003987.3, ENSRNOT00000003987.6

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_017322.2 → NP_059018.1 mitogen-activated protein kinase 9 isoform 1

See identical proteins and their annotated locations for NP_059018.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BC061870, BI282175, DN948189, JAXUCZ010000010, L27112

UniProtKB/Swiss-Prot

P49186

UniProtKB/TrEMBL

A0A0G2JYS4, A6HDY4

Related

ENSRNOP00000087042.1, ENSRNOT00000116124.1

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

34670750..34711972

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269678.1 → XP_063125748.1 mitogen-activated protein kinase 9 isoform X3

UniProtKB/TrEMBL

D4A5V8
XM_017597479.3 → XP_017452968.1 mitogen-activated protein kinase 9 isoform X5

UniProtKB/TrEMBL

A6HDY6

Conserved Domains (1) summary

cl21453
Location:25 → 210

PKc_like; Protein Kinases, catalytic domain
XM_039086658.2 → XP_038942586.1 mitogen-activated protein kinase 9 isoform X2

UniProtKB/TrEMBL

A0A8I6A503

Conserved Domains (1) summary

cd07850
Location:16 → 334

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
XM_006246318.5 → XP_006246380.1 mitogen-activated protein kinase 9 isoform X1

See identical proteins and their annotated locations for XP_006246380.1

UniProtKB/TrEMBL

A0A8I6A503, A0A8I6AND2

Related

ENSRNOP00000090510.1

Conserved Domains (1) summary

cd07850
Location:16 → 334

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
XM_039086659.2 → XP_038942587.1 mitogen-activated protein kinase 9 isoform X4

Conserved Domains (1) summary

cl21453
Location:1 → 240

PKc_like; Protein Kinases, catalytic domain