Cd177 CD177 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cd177provided by RGD
Full Name: CD177 moleculeprovided by RGD
Primary source: RGD:1562941
See related: Ensembl:ENSRNOG00000022669 AllianceGenome:RGD:1562941
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562941
Summary: Predicted to enable calcium-dependent protein binding activity; integrin binding activity; and protease binding activity. Predicted to be involved in several processes, including neutrophil extravasation; positive regulation of superoxide anion generation; and regulation of vesicle-mediated transport. Predicted to be located in plasma membrane and tertiary granule membrane. Predicted to be active in plasma membrane raft. Predicted to be anchored component of plasma membrane. Orthologous to human CD177 (CD177 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 116.9), Spleen (RPKM 17.3) and 2 other tissues See more
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Genomic context

Location:: 1q21

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (89467926..89488490, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (80340034..80360599, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (82964683..82987306, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in cell-cell junction maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction maintenance	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in neutrophil extravasation	ISO Inferred from Sequence Orthology more info
NOT involved_in neutrophil migration	ISO Inferred from Sequence Orthology more info
involved_in neutrophil migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil degranulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neutrophil degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
located_in secretory granule membrane	ISO Inferred from Sequence Orthology more info
located_in tertiary granule membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD177 antigen

Names: CD177 antigen-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.