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    SMG6 SMG6 nonsense mediated mRNA decay factor [ Canis lupus familiaris (dog) ]

    Gene ID: 491199, updated on 8-Mar-2024

    Summary

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    Official Symbol
    SMG6provided by VGNC
    Official Full Name
    SMG6 nonsense mediated mRNA decay factorprovided by VGNC
    Primary source
    VGNC:VGNC:46556
    See related
    Ensembl:ENSCAFG00845014001
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See SMG6 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (46993865..47236967, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (45313087..45555769, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (46110273..46353691, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (45760897..46003941, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (46055223..46298431, complement)

    Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene microRNA mir-212 Neighboring gene HIC ZBTB transcriptional repressor 1 Neighboring gene uncharacterized LOC119873336 Neighboring gene cytochrome b-c1 complex subunit 6, mitochondrial-like Neighboring gene LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) pseudogene Neighboring gene small nucleolar RNA SNORD91 family Neighboring gene small nucleolar RNA SNORD91 family Neighboring gene serine racemase Neighboring gene TSR1 ribosome maturation factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables telomerase RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of telomerase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    telomerase-binding protein EST1A
    Names
    smg-6 homolog, nonsense mediated mRNA decay factor
    XP_005625005.1
    XP_022279165.1
    XP_022279167.1
    XP_022279168.1
    XP_038342563.1
    XP_038342564.1
    XP_038342565.1
    XP_038342566.1
    XP_038342567.1
    XP_038342568.1
    XP_038404427.1
    XP_038404428.1
    XP_038404429.1
    XP_038404430.1
    XP_038404431.1
    XP_038404432.1
    XP_038468363.1
    XP_038468364.1
    XP_038468365.1
    XP_038468366.1
    XP_038468367.1
    XP_038468368.1
    XP_038468982.1
    XP_038533641.1
    XP_038533642.1
    XP_038533643.1
    XP_038533644.1
    XP_038533645.1
    XP_038533646.1
    XP_548319.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051813.1 Reference ROS_Cfam_1.0

      Range
      46993865..47236967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038677713.1 → XP_038533641.1  telomerase-binding protein EST1A isoform X1

      UniProtKB/TrEMBL
      A0A8C0K9R9, A0A8C0NFK7, A0A8C0RWT3, A0A8I3NI36
      Related
      ENSCAFP00845019707.1, ENSCAFT00845025047.1
      Conserved Domains (3) summary
      cd09885
      Location:1234 → 1409
      PIN_Smg6-like; VapC-like PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    2. XM_038677714.1 → XP_038533642.1  telomerase-binding protein EST1A isoform X2

      UniProtKB/TrEMBL
      A0A8C0RWT3
      Conserved Domains (3) summary
      cd09885
      Location:1223 → 1398
      PIN_Smg6-like; VapC-like PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs
      pfam10373
      Location:733 → 1085
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:620 → 725
      EST1; Telomerase activating protein Est1

    3. XM_038677715.1 → XP_038533643.1  telomerase-binding protein EST1A isoform X3

      UniProtKB/TrEMBL
      A0A8I3NPA4, A0A8P0TL14
      Conserved Domains (3) summary
      sd00006
      Location:758 → 788
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    4. XM_038677716.1 → XP_038533644.1  telomerase-binding protein EST1A isoform X4

      UniProtKB/TrEMBL
      A0A8I3NPA4, A0A8P0TL14
      Conserved Domains (2) summary
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    5. XM_038677717.1 → XP_038533645.1  telomerase-binding protein EST1A isoform X5

      UniProtKB/TrEMBL
      A0A8I3NPA4, A0A8P0TL14
      Related
      ENSCAFP00845019764.1, ENSCAFT00845025131.1
      Conserved Domains (3) summary
      sd00006
      Location:758 → 788
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    6. XM_038677718.1 → XP_038533646.1  telomerase-binding protein EST1A isoform X6

      UniProtKB/TrEMBL
      A0A8I3NPA4, A0A8P0TL14
      Conserved Domains (2) summary
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    RNA

    1. XR_005432543.1 RNA Sequence

    2. XR_005432544.1 RNA Sequence

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049269.1 Alternate UMICH_Zoey_3.1

      Range
      45760897..46003941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038486635.1 → XP_038342563.1  telomerase-binding protein EST1A isoform X1

      Conserved Domains (3) summary
      cd09885
      Location:1234 → 1409
      PIN_Smg6-like; VapC-like PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    2. XM_038486636.1 → XP_038342564.1  telomerase-binding protein EST1A isoform X2

      Conserved Domains (3) summary
      cd09885
      Location:1223 → 1398
      PIN_Smg6-like; VapC-like PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs
      pfam10373
      Location:733 → 1085
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:620 → 725
      EST1; Telomerase activating protein Est1

    3. XM_038486637.1 → XP_038342565.1  telomerase-binding protein EST1A isoform X3

      Conserved Domains (3) summary
      sd00006
      Location:758 → 788
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    4. XM_038486638.1 → XP_038342566.1  telomerase-binding protein EST1A isoform X4

      Conserved Domains (2) summary
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    5. XM_038486639.1 → XP_038342567.1  telomerase-binding protein EST1A isoform X5

      Conserved Domains (3) summary
      sd00006
      Location:758 → 788
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    6. XM_038486640.1 → XP_038342568.1  telomerase-binding protein EST1A isoform X6

      Conserved Domains (2) summary
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    RNA

    1. XR_005331073.1 RNA Sequence

    2. XR_005331074.1 RNA Sequence

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

      Range
      46055223..46298431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038612435.1 → XP_038468363.1  telomerase-binding protein EST1A isoform X1

      Conserved Domains (3) summary
      cd09885
      Location:1234 → 1409
      PIN_Smg6-like; VapC-like PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    2. XM_038612436.1 → XP_038468364.1  telomerase-binding protein EST1A isoform X2

      Conserved Domains (3) summary
      cd09885
      Location:1223 → 1398
      PIN_Smg6-like; VapC-like PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs
      pfam10373
      Location:733 → 1085
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:620 → 725
      EST1; Telomerase activating protein Est1

    3. XM_038612437.1 → XP_038468365.1  telomerase-binding protein EST1A isoform X3

      Conserved Domains (3) summary
      sd00006
      Location:758 → 788
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    4. XM_038612438.1 → XP_038468366.1  telomerase-binding protein EST1A isoform X4

      Conserved Domains (2) summary
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    5. XM_038612439.1 → XP_038468367.1  telomerase-binding protein EST1A isoform X5

      Conserved Domains (3) summary
      sd00006
      Location:758 → 788
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    6. XM_038612440.1 → XP_038468368.1  telomerase-binding protein EST1A isoform X6

      Conserved Domains (2) summary
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    RNA

    1. XR_005399207.1 RNA Sequence

    2. XR_005399208.1 RNA Sequence

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

      Range
      46110273..46353691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038548499.1 → XP_038404427.1  telomerase-binding protein EST1A isoform X1

      UniProtKB/TrEMBL
      A0A8C0K9R9, A0A8C0NFK7, A0A8C0RWT3, A0A8I3NI36
      Conserved Domains (3) summary
      cd09885
      Location:1234 → 1409
      PIN_Smg6-like; VapC-like PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    2. XM_038548500.1 → XP_038404428.1  telomerase-binding protein EST1A isoform X2

      UniProtKB/TrEMBL
      A0A8C0RWT3
      Conserved Domains (3) summary
      cd09885
      Location:1223 → 1398
      PIN_Smg6-like; VapC-like PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs
      pfam10373
      Location:733 → 1085
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:620 → 725
      EST1; Telomerase activating protein Est1

    3. XM_038548501.1 → XP_038404429.1  telomerase-binding protein EST1A isoform X3

      UniProtKB/TrEMBL
      A0A8I3NPA4, A0A8P0TL14
      Conserved Domains (3) summary
      sd00006
      Location:758 → 788
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    4. XM_038548502.1 → XP_038404430.1  telomerase-binding protein EST1A isoform X4

      UniProtKB/TrEMBL
      A0A8I3NPA4, A0A8P0TL14
      Conserved Domains (2) summary
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    5. XM_038548503.1 → XP_038404431.1  telomerase-binding protein EST1A isoform X5

      UniProtKB/TrEMBL
      A0A8I3NPA4, A0A8P0TL14
      Conserved Domains (3) summary
      sd00006
      Location:758 → 788
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    6. XM_038548504.1 → XP_038404432.1  telomerase-binding protein EST1A isoform X6

      UniProtKB/TrEMBL
      A0A8I3NPA4, A0A8P0TL14
      Conserved Domains (2) summary
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    RNA

    1. XR_005364773.1 RNA Sequence

    2. XR_005364774.1 RNA Sequence

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      45313087..45555769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_548319.7 → XP_548319.3  telomerase-binding protein EST1A isoform X1

      UniProtKB/TrEMBL
      A0A8C0K9R9, A0A8C0NFK7, A0A8C0RWT3, A0A8I3NI36
      Conserved Domains (3) summary
      cd09885
      Location:1234 → 1409
      PIN_Smg6-like; VapC-like PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    2. XM_005624948.4 → XP_005625005.1  telomerase-binding protein EST1A isoform X2

      UniProtKB/TrEMBL
      A0A8C0RWT3
      Conserved Domains (3) summary
      cd09885
      Location:1223 → 1398
      PIN_Smg6-like; VapC-like PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs
      pfam10373
      Location:733 → 1085
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:620 → 725
      EST1; Telomerase activating protein Est1

    3. XM_022423457.2 → XP_022279165.1  telomerase-binding protein EST1A isoform X3

      UniProtKB/TrEMBL
      A0A8I3NPA4, A0A8P0TL14
      Conserved Domains (3) summary
      sd00006
      Location:758 → 788
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    4. XM_022423459.2 → XP_022279167.1  telomerase-binding protein EST1A isoform X4

      UniProtKB/TrEMBL
      A0A8I3NPA4, A0A8P0TL14
      Conserved Domains (2) summary
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    5. XM_038613054.1 → XP_038468982.1  telomerase-binding protein EST1A isoform X5

      UniProtKB/TrEMBL
      A0A8I3NPA4, A0A8P0TL14
      Conserved Domains (3) summary
      sd00006
      Location:758 → 788
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    6. XM_022423460.2 → XP_022279168.1  telomerase-binding protein EST1A isoform X6

      UniProtKB/TrEMBL
      A0A8I3NPA4, A0A8P0TL14
      Conserved Domains (2) summary
      pfam10373
      Location:744 → 1096
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:631 → 736
      EST1; Telomerase activating protein Est1

    RNA

    1. XR_005399376.1 RNA Sequence

    2. XR_005399383.1 RNA Sequence

    Nucleotide Protein
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