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    NKG7 natural killer cell granule protein 7 [ Homo sapiens (human) ]

    Gene ID: 4818, updated on 7-Apr-2024

    Summary

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    Official Symbol
    NKG7provided by HGNC
    Official Full Name
    natural killer cell granule protein 7provided by HGNC
    Primary source
    HGNC:HGNC:7830
    See related
    Ensembl:ENSG00000105374 MIM:606008; AllianceGenome:HGNC:7830
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GIG1; GMP-17; p15-TIA-1
    Summary
    Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bone marrow (RPKM 170.3), spleen (RPKM 54.6) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NKG7 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51371620..51372654, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54460261..54461295, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51874874..51875908, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene electron transfer flavoprotein subunit beta Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:51869249-51870208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:51871167-51872126 Neighboring gene claudin domain containing 2 Neighboring gene uncharacterized LOC124904752 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51879781-51880038 Neighboring gene lens intrinsic membrane protein 2 Neighboring gene LIM2 and SIGLEC10 antisense RNA 1 Neighboring gene chromosome 19 open reading frame 84

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition. Medley QG, et al. Proc Natl Acad Sci U S A, 1996 Jan 23. PMID 8570616, Free PMC Article
    2. Characterization of a novel gene (NKG7) on human chromosome 19 that is expressed in natural killer cells and T cells. Turman MA, et al. Hum Immunol, 1993 Jan. PMID 8458737
    3. Molecular cloning and characterization of G-CSF induced gene cDNA. Shimane M, et al. Biochem Biophys Res Commun, 1994 Feb 28. PMID 7510105
    4. The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Ng SS, et al. Nat Immunol, 2020 Oct. PMID 32839608, Free PMC Article
    5. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CD4-positive, alpha-beta T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in defense response to protozoan IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in granzyme-mediated programmed cell death signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in killing of cells of another organism IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in natural killer cell degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in natural killer cell mediated cytotoxicity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in natural killer cell mediated cytotoxicity directed against tumor cell target ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytolytic granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytolytic granule membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein NKG7
    Names
    G-CSF-induced gene 1 protein
    GIG-1 protein
    granule membrane protein 17
    granule membrane protein of 17 kDa
    natural killer cell group 7 sequence
    natural killer cell protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363693.2 → NP_001350622.1  protein NKG7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI313472, BG743982, S69115
      Consensus CDS
      CCDS86796.1
      UniProtKB/TrEMBL
      A0A0B4J2A6
      Related
      ENSP00000468910.1, ENST00000595217.1

    2. NM_005601.4 → NP_005592.1  protein NKG7 isoform 1

      See identical proteins and their annotated locations for NP_005592.1

      Status: VALIDATED

      Source sequence(s)
      AI313472, S69115
      Consensus CDS
      CCDS12830.1
      UniProtKB/Swiss-Prot
      Q16617
      Related
      ENSP00000221978.4, ENST00000221978.10
      Conserved Domains (1) summary
      cl21598
      Location:21 → 149
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      51371620..51372654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006723228.4 → XP_006723291.1  protein NKG7 isoform X2

      Conserved Domains (1) summary
      cl21598
      Location:50 → 100
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    2. XM_005258955.4 → XP_005259012.1  protein NKG7 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      54460261..54461295 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321079.1 → XP_054177054.1  protein NKG7 isoform X2

    2. XM_054321078.1 → XP_054177053.1  protein NKG7 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16617.1 GenPept UniProtKB/Swiss-Prot:Q16617

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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