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1. |
FOXP3 functions not only to suppress the first wave of NFAT-mediated transcriptional responses, but may also affect sustained NFAT-mediated inflammatory gene expression through suppression of inducible NFAT2 transcription |
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2. |
results suggest that p65/RelA and NFATc1 bind to the intronic NF-kappaB site 1 sequence to induce optimal transcription of the ICAM-1 gene in response to thrombin in endothelial cells |
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3. |
These results demonstrate the role of calcineurin-NFAT pathway in lymphangiogenesis and suggest that NFATc1 is the principle NFAT involved. |
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4. |
Data show that upon sumoylation, NFATc1/C translocates to nuclear bodies, which leads to deacetylation of histones, which in turn induces transcriptionally inactive chromatin and suppression of the NFATc1 target gene interleukin-2. |
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5. |
Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis |
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6. |
these data suggest that the proinflammatory, antiapoptotic, and procarcinogenic functions of UV-activated COX-2 may be mediated, in part, by upstream NFAT signaling. |
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7. |
cyclic AMP signals enhance histone H3 acetylation at the IL-5 promoter and the concerted binding of GATA-3 and NFATc to the promoter. |
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8. |
the cyclin A-CDK2 complex may be a potential effector of NFATs, specifically NFATc1, in mediating SMC multiplication leading to neointima formation. |
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9. |
Report nucleo-translocation/activation of NFAT2 in lamina propria mononuclear cells in ulcerative colitis. |
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10. |
The crystal structure of NFATC1 bound to the HIV-1 LTR tandem kappaB enhancer element is described. |
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11. |
These data provide evidence that NFATc1, in concert with PU.1, are involved in regulation of beta(3) integrin expression during osteoclast differentiation. |
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12. |
histone modifications precede the DNA methylation in NFATC1 promoter silencing |
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13. |
The promoter/enhancer activity of the NFAT-binding site in the TNF-alpha gene was up-regulated by NFATc2 but not by NFATc1, whereas both NFATs associated similarly with this region. |
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14. |
Observational study of gene-disease association. (HuGE Navigator) |
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15. |
DSCR1 gene is a direct transcriptional target of NFATc1 proteins within the endocardium during a critical window of heart valve formation. |
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16. |
the concerted action of the transcription factors Egr1 and NFAT2 can play a crucial role in regulation of the T cell differentiation in vitro due to the cooperative regulation of Id3 and Rag2 gene expression. |
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17. |
Our results provide evidence that NFAT2 is constitutively expressed in human neutrophils, and after IgE-dependent activation operates as a transcription factor in the modulation of genes, such as COX2, during allergic inflammation. |
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18. |
The expression pattern of NFAT and its family member- and lineage-specific regulation during myeloid differentiation will prompt further studies on the role of NFAT in myeloid cells, particularly in megakaryocytes. |
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19. |
Unstimulated adult skeletal muscle fibers exhibit a previously unanticipated nucleocytoplasmic shuttling of NFATc1 without appreciable nuclear accumulation. |
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20. |
AMPK mediates IL-2 production by regulating NF-AT and AP-1activation during T cell stimulation. |
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21. |
Tacrolimus or cyclosporine A act on human osteoclast precursors in rheumatoid arthritis patients by targeting the calcineurin-dependent NFAT pathway and activation pathway for c-Jun or MITF. |
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22. |
Together, these results demonstrate that ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway is an important mechanism of oncogenic c-myc activation in pancreatic cancer. |
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23. |
NFATc1 with AP-3 site binding specificity has a role in mediating gene expression of prostate-specific-membrane-antigen |
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24. |
C-terminal one third of DNA binding domain confers different binding specificity of NFATc and NFATp to an NFAT site in the TNF-alpha promoters |
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25. |
PC1 signaling elevates intracellular Ca(2+), activates Galpha(q) and PLC, which then activates calcineurin and NFAT |
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26. |
In Wiskott-Aldrich CD8+ T cells, a block in cytokine production correlates with reduced nuclear levels of both NFAT-1 and NFAT-2. |
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27. |
NFAT2 has a role in regulating IL13 gene transcription in mast cells |
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28. |
selective expression in basophils suggests involvement in IgE-mediated IL-4 production in these cells |
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29. |
selection of RNA inhibitors to study NFATc function |
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30. |
analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts |
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31. |
role of PKCzeta in T cells through the control of NFAT function by modulating the activity of its transactivation domain |
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32. |
opposition of calcineurin-mediated nuclear accumulation and transcriptional activity by glycogen synthase kinase 3 |
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33. |
mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells |
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34. |
These results establish the beta3 gene as a direct target of NFATc1 in RANKL-dependent osteoclast formation. |
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35. |
NFAT1, a transcription factor connected with breast cancer metastasis, is activated by Wnt-5a through a Ca2+ signaling pathway in human breast epithelial cells which was simultaneously counteracted by a Wnt-5a-induced Yes/Cdc42 signaling pathway. |
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36. |
Expression of NFATc1/alphaA, the most prominent of six NFATc1 isoforms in peripheral T cells, is strongly induced following T-cell receptor and co-receptor stimulation and maintained by positive autoregulation, as discussed in this review. |
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37. |
Endothelin 1 (ET-1) activates calcineurin and causes nuclear translocation of NFATc1, implicating the pathway in the ET-1-mediated stimulation of osteoblasts. |
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38. |
RANKL-induced cathepsin K gene expression is cooperatively regulated by the combination of the transcription factors and p38 MAP kinase in a gradual manner. |
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39. |
Interleukin (IL)-15 and IL-2 reciprocally regulate expression of the chemokine receptor CX3CR1 through selective NFAT1- and NFAT2-dependent mechanisms |
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40. |
association of nuclear factor-kappaB and NFAT with its enhancer region is dependent on activation of the HIV-1 clade E long terminal repeat, which is inhibited by T-cell activation |
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41. |
role in congenital heart disease |
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42. |
Expression of NFATc1 and NFATc2 wild type protein or the active catalytic subunit of calcineurin transactivates COX-2 promoter activity, whereas a dominant negative mutant of NFAT inhibited COX-2 induction in colon carcinoma cell lines. |
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43. |
the MCP-1-induced TRAP(+)/CTR(+) multinuclear cells represent an arrested stage in osteoclast differentiation, after NFATc1 induction and cellular fusion but prior to the development of bone resorption activity |
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44. |
the beta3 integrin gene is the direct target of NFAT1 in osteoclast formation |