1: MICB MHC class I polypeptide-related sequence B [ Homo sapiens ]

GeneID: 4277 updated 11-Oct-2009

[Top][Help]Summary

Official Symbol
MICBprovided by HGNC
Official Full Name
MHC class I polypeptide-related sequence Bprovided by HGNC
Primary Source
HGNC:7091
Locus Tag
DAAP-210H10.1
See related
Ensembl:ENSG00000204516; HPRD:03894; MIM:602436
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PERB11.2; MICB
Summary
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. [provided by RefSeq]

[Top][Help]Genomic regions, transcripts, and products

(plus) Go to reference sequence detailsTry our new Sequence Viewer


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Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. Growth supernatant from propionibacteria or propionate alone could directly stimulate functional MICA/B surface expression and MICA promoter activity by a mechanism dependent on intracellular calcium
PubMed 2. shedding of the immunostimulatory MHC class I chain-related gene B prevents tumor formation
PubMed 3. CD14(+) monocytes promote NKG2D(+)CD4(+) T cells activation through the NKG2D-MIC engagement in the pathogenesis of systemic lupus erytematosus.
PubMed 4. Expression of MICA/B was detected in 97.6 of ovarian cancer cells,but not on normal ovarian epithelium. The expression of MICA/B in ovarian cancer was highly correlated with that of ULBP2.
PubMed 5. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
PubMed 6. MICB*004 allele frequency is significantly increased in multiple sclerosis patients.
PubMed 7. Common MICA and MICB genetic variations are not associated with susceptibility to type 1 diabetes.
PubMed 8. Elevated soluble MICB levels exist in serum of multiple sclerosis patients related with disease activity.
PubMed 9. while infection with wild-type Ad enhances synthesis of the NKG2D ligands, MICA and MICB, their expression on the cell surface is actively suppressed.
PubMed 10. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
PubMed 11. Observational study of genotype prevalence. (HuGE Navigator)
PubMed 12. Observational study of gene-disease association. (HuGE Navigator)
PubMed 13. study reports that the MICB 0050204(1) allele, present in the majority of the Spanish population (70% of healthy controls) is characterized by the presence of an extra exon found between the sequence corresponding to exon 1 and 2
PubMed 14. upregulation of MICA and MICB by treatment with TsA leads to enhancement of the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells
PubMed 15. MICB protein polymorphism is implicated in human herpes virus seropositivity and schizophrenia risk.
PubMed 16. variations in MICB expression among normal individuals could imply a significant difference in the natural immune response against infections or tumor transformation
PubMed 17. From pairwise associations in the random panel and results for the homozygous cell lines it was possible to deduce the MICA and MICB microsatellite alleles present in many of the well-known Caucasoid
PubMed 18. Circulating soluble MICB in cancer patients deactivates natural killer (NK) cell-mediated NK immunity by down-modulating important activating and chemokine receptors in vitro and in vivo.
PubMed 19. In a study of mainly paucibacillary leprosy-affected sib-pair families from South India, we have identified significant association with a functional variant of the MICA gene as well as a microsatellite in the flanking region of the MICB gene.
PubMed 20. new allele is identical to MICB-0103101v except for a single mutation of G to A in exon 4 that translates into an amino acid substitution from glutamic acid to lysine
PubMed 21. micb, overexpressed on a subset of human HCCs, may play an important role in their susceptibility to NK cells.
PubMed 22. MICB promoter polymorphism haplotypes showed strong linkage disequilibrium with MICB alleles.
PubMed 23. MICB, the second member of the human MIC protein family, is likewise shed by metalloproteases from tumor cells and is present in sera of patients with gastrointestinal tumors.
PubMed 24. study shows that human cytomegalovirus-miR-UL112 specifically down-regulates MICB expression during viral infection, leading to decreased binding of NKG2D and reduced killing by NK cells
PubMed 25. Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells
PubMed 26. analysis of human, chimpanzee and rhesus monkey MHC-B and MHC-C DNA gives insight to the time frame of human divergence from Old World monkeys
PubMed 27. Engagement of MIC by NKG2D promotes spontaneous HAM/TSP T cell proliferation and, apparently, CTL activities against HTLV-1-infected T cells.
PubMed 28. an Alu repeat dimorphism within the first intron of the MICB gene was found
PubMed 29. binding of MICA and MICB induces endocytosis and downregulation of NKG2D, and in turn severe impairment of the responsiveness of tumour-antigen-specific effector T cells
PubMed 30. Determination of sMICA and sMICB levels may be implemented as a prognostic parameter in patients with hematopoietic malignancies.
PubMed 31. The polymorphisms and haplotype distributions of MICA and MICB microsatellite and HLA-B locus in the Guangzhou Han population have their own distinct genetic characteristics
PubMed 32. eight novel MICB variants, including a null allele, which were identified in peripheral blood leukocytes of gastric MALT lymphoma patients.
PubMed 33. high frequency of the MIC null haplotype, HLA-B48-MICA-del-MICB*0107 N, in the Angaite Amerindian community in Paraguay
PubMed 34. MICB is induced on dendritic cells upon IFN-alpha stimulation and is capable of activating NK cells by a mechanism that is impaired in hepatitis C virus infection.
PubMed 35. reveal distinct modes of activation of the genes for the MIC ligands of NKG2D and provide a molecular framework for analyses of gene regulation under different cellular insult conditions
PubMed 36. MICB-CA18 is positively associated with ulcerative colitis and female ulcerative colitis patients in a Chinese population.
PubMed 37. NKG2D and MICB in the cytotoxic NK cell immune synapse have roles in NK cell cytotoxic function

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
 
  MICB   NP_038459.1        HPRD    PubMed
 
  NP_005922.1   NP_031386.1        HPRD    PubMed
 
  NP_005922.1   NKG2D        HPRD    PubMed
 
  NP_005922.1   Vdelta 1 gamma delta TCR        HPRD    PubMed

[Top][Help]General gene information

Markers

AluyMICB_503(no_Alu)(e-PCR)
Links: UniSTS:509993
D6S2672(e-PCR)
Links: UniSTS:515935
D1S1423(e-PCR)
Links: UniSTS:149619
MICB_1889.2(e-PCR)
Links: UniSTS:468085
STS-U65416(e-PCR)
Links: UniSTS:30343
D6S2793(e-PCR)
Links: UniSTS:464280
D6S2793(e-PCR)
Links: UniSTS:464281
STS-X91625(e-PCR)
Links: UniSTS:46271
D6S2672(e-PCR)
Links: UniSTS:256723
C1_2_A(e-PCR)
Links: UniSTS:239063

Phenotypes

Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02).
NHGRI GWA Catalog

Homology

Homologs of the MICB gene The MICB gene is conserved in chimpanzee, cow, mouse, and rat.


Map Viewer (Mouse, Rat)

Pathways

KEGG pathway: Natural killer cell mediated cytotoxicity
04650
Reactome Event:Signaling in Immune system
REACT_6900

[Top][Help]General protein information

Preferred Names
MHC class I polypeptide-related sequence B
Names
MHC class I polypeptide-related sequence B
MHC class I molecule
MHC class I mic-B antigen
stress inducible class I homolog
MHC class I chain-related protein B
MHC class I-like molecule PERB11.2-IMX
NP_005922.2
5` partial

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_005931.3NP_005922.2  MHC class I polypeptide-related sequence B precursor

    Source sequence(s)
    AF021224,AL663061,BQ216247,CN389975,DC427936,U95734
    Consensus CDS
    CCDS43449.1
    UniProtKB/Swiss-Prot
    Q29980
    Conserved Domains (2) summary
    cd00098
    Location:204288
    Blast Score: 144
    IGc; Immunoglobulin domain constant region subfamily; members of the IGc subfamily are components of immunoglobulins, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and Major Histocompatibility Complex (MHC) class I/II...
    pfam00129
    Location:25198
    Blast Score: 227
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000006.11

    Range
    31465854..31478900
    Download
    GenBank FASTA Sequence Viewer (Graphics)
  2. NT_007592.15 

    Range
    31405854..31418900
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_1

Genomic

  1. NT_167244.1 Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_1

    Range
    2780561..2793589
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_2

Genomic

  1. NT_113891.2 Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_2

    Range
    2975523..2988569
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_3

Genomic

  1. NT_167245.1 Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_3

    Range
    2751270..2764494
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_4

Genomic

  1. NT_167246.1 Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_4

    Range
    2816314..2821819
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_5

Genomic

  1. NT_167247.1 Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_5

    Range
    2845616..2858655
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_6

Genomic

  1. NT_167248.1 Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_6

    Range
    2759573..2772597
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_7

Genomic

  1. NT_167249.1 Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_7

    Range
    2796670..2809703
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000049.1

    Range
    33071632..33077143
    Download
    GenBank FASTA Sequence Viewer (Graphics)
  2. NW_923073.1 

    Range
    4535953..4541464
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000138.1

    Range
    31252689..31265722
    Download
    GenBank FASTA Sequence Viewer (Graphics)
  2. NW_001838980.1 

    Range
    4524998..4538031
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AB003609.2   BAA23476.1
  genomic   AB003610.2   BAA23477.1
  genomic   AB003611.2   BAA23478.1
  genomic   AB003612.2   BAA23479.1
  genomic   AB003613.2   BAA23480.1
  genomic   AB003614.2   BAA23481.1
  genomic   AB003615.2   BAA23482.1
  genomic   AB003616.2   BAA23483.1
  genomic   AB003617.2   BAA23484.1
  genomic   AB003618.2   BAA23485.1
  genomic   AB088107.1   BAC54939.1
  genomic   AB202111.1   BAE78634.1
  genomic   AJ251156.1   CAB72101.1
  genomic   AJ251158.1   CAB72097.1
  genomic   AJ251160.1   CAB72098.1
  genomic   AJ563706.1   CAD91554.1
  genomic   AJ606906.1   CAE54932.1
  genomic   AJ606907.1   CAE54933.1
  genomic   AJ606908.1   CAE54934.1
  genomic   AJ606909.1   CAE54935.1
  genomic   AJ606910.1   CAE54936.1
  genomic   AJ606911.1   CAE54937.1
  genomic   AJ606912.1   CAE54938.1
  genomic   AJ606913.1   CAE54939.1
  genomic   AJ606914.1   CAE54940.1
  genomic   AJ606915.1   CAE54941.1
  genomic   AJ606916.1   CAE54942.1
  genomic   AJ606917.1   CAE54943.1
  genomic   AJ606918.1   CAE54944.1
  genomic   AJ606919.1   CAE54945.1
  genomic   AJ606920.1   CAE54946.1
  genomic   AJ606921.1   CAE54947.1
  genomic   AJ606922.1   CAE54948.1
  genomic   AJ606923.1   CAE54949.1
  genomic   AJ606927.1   CAE54953.1
  genomic   AJ606928.1   CAE54954.1
  genomic   AJ606929.1   CAE54955.1
  genomic   AJ606930.1   CAE54956.1
  genomic   AJ606931.1   CAE54957.1
  genomic   AL662866.7   CAI17555.1
  genomic   AL663061.8   CAI18082.1
  genomic   BA000025.2   BAB63307.1
  genomic   BX001040.14   CAI18629.1
       CAI18630.1
  genomic   BX005439.8   CAI18747.1
       CAI18748.1
  genomic   BX927320.5  (5361..10866)   None
  genomic   CH471081.1   EAX03402.1
       EAX03403.1
  genomic   CR753820.15  (27655..40879)   None
  genomic   CR753864.4  (33713..46752)   None
  genomic   CR788288.6   CAQ09224.1
       CAQ09225.1
  genomic   U65416.1   AAB42011.1
  genomic   U69978.1   AAB51802.1
  mRNA   AF021221.1   AAC39846.1
  mRNA   AF021222.1   AAC39847.1
  mRNA   AF021223.1   AAC39848.1
  mRNA   AF021224.1   AAC39849.1
  mRNA   AF021225.1   AAC39850.1
  mRNA   AF021226.1   AAC39851.1
  mRNA   AK291927.1   BAF84616.1
  mRNA   AK300791.1   BAG62451.1
  mRNA   AK303655.1   BAH14007.1
  mRNA   AK314228.1   BAG36899.1
  mRNA   AY885251.1   None
  mRNA   BC044218.1   AAH44218.1
  mRNA   BQ216247.1   None
  mRNA   BU684700.1   None
  mRNA   CN389975.1   None
  mRNA   DC427936.1   None
  mRNA   U95729.1   AAB71642.1
  mRNA   U95730.1   AAB71643.1
  mRNA   U95731.1   AAB71644.1
  mRNA   U95732.1   AAB71645.1
  mRNA   U95733.1   AAB71646.1
  mRNA   U95734.1   AAB71647.1
  mRNA   X91625.1   CAA62823.1
Protein Accession   Links
Q0EFB4   GenPept   UniProtKB/TrEMBL:Q0EFB4
Q29980.1   GenPept   UniProtKB/Swiss-Prot:Q29980
Q5RIY5   GenPept   UniProtKB/TrEMBL:Q5RIY5
Q861E6   GenPept   UniProtKB/TrEMBL:Q861E6

[Top][Help]Additional Links