LTF lactotransferrin [Sus scrofa (pig)] - Gene

Summary

Official Symbol: LTFprovided by VGNC
Official Full Name: lactotransferrinprovided by VGNC
Primary source: VGNC:VGNC:89891
See related: Ensembl:ENSSSCG00000029879
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: PLF
Expression: Broad expression in ovary (RPKM 6.3), lung (RPKM 3.2) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	13	NC_010455.5 (29413886..29445751, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	13	NC_010455.4 (32577743..32609425, complement)

Chromosome 13 - NC_010455.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this paper shows that recombinant lactoferrin peptide LF-6 produced with intein technology has both antibacterial and immunomodulatory activity in mice
Title: Recombinant expression of porcine lactoferrin peptide LF-6 with intein technology and its immunomodulatory function in ETEC K88-infected mice.
We propose that lactoferrin functions in the immune defense of the small intestinal mucosa by targeting the population of T cells in the lamina propria
Title: Lactoferrin targets T cells in the small intestine.
Involvement of HSP27 and lactoferrin in porcine endometrium and neutrophils activity.
Title: Estrous cycle-dependent activity of neutrophils in the porcine endometrium: possible involvement of heat shock protein 27 and lactoferrin.
Growth performance of animal pups is enhanced by directly feeding the genetically engineered milk containing enriched pLF protein in transgenic mice.
Title: Recombinant porcine lactoferrin expressed in the milk of transgenic mice enhances offspring growth performance.

Submit: New GeneRIF Correction

General gene information

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Markers

SW1400 (e-PCR), detects polymorphism
- UniSTS:252462

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables iron ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in antifungal humoral response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cytokine production	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in early endosome	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in recycling endosome	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: lactotransferrin

Names: lactoferrin

NP_999527.2

EC 3.4.21.-

XP_020924222.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214362.3 → NP_999527.2 lactotransferrin precursor

Status: PROVISIONAL

Source sequence(s)

AEMK02000085

UniProtKB/TrEMBL

A0A4X1T9V8, A0A8W4FE96

Related

ENSSSCP00000076635.1, ENSSSCT00000101357.1

Conserved Domains (2) summary

cd13617
Location:358 → 688

PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

cd13618
Location:25 → 347

PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010455.5 Reference Sscrofa11.1 Primary Assembly

Range

29413886..29445751 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021068563.1 → XP_020924222.1 lactotransferrin isoform X1

UniProtKB/TrEMBL

A0A4X1T9C7, Q6YT39

Related

ENSSSCP00000026769.1, ENSSSCT00000030564.3

Conserved Domains (2) summary

cd13617
Location:358 → 688

PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

cd13618
Location:25 → 347

PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily