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    EBNA-3A nuclear antigen EBNA-3A [ Human gammaherpesvirus 4 (Epstein-Barr virus) ]

    Gene ID: 3783762, updated on 18-Aug-2023

    Summary

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    Gene symbol
    EBNA-3A
    Gene description
    nuclear antigen EBNA-3A
    Locus tag
    HHV4_EBNA-3A
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human gammaherpesvirus 4 (strain: B95-8, strain: Raji, type: 1, common: Epstein-Barr virus, acronym: EBV, acronym: HHV-4, nat-host: Homo sapiens)
    Lineage
    Viruses; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus
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    Genomic context

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    Sequence:
    NC_007605.1 (11305..82962)

    NC_007605.1Genomic Context describing neighboring genes Neighboring gene nuclear antigen EBNA-3B;nuclear antigen EBNA-3C Neighboring gene membrane protein LMP-2B Neighboring gene membrane protein LMP-2A Neighboring gene tegument protein G75 Neighboring gene interleukin-10 BCRF1 Neighboring gene nuclear antigen EBNA-2 Neighboring gene protein-coding Neighboring gene nuclear antigen EBNA-LP Neighboring gene protein BWRF1 Neighboring gene protein BWRF1 Neighboring gene protein BWRF1 Neighboring gene protein BWRF1 Neighboring gene protein BWRF1 Neighboring gene protein BWRF1 Neighboring gene protein BWRF1 Neighboring gene protein BWRF1 Neighboring gene protein BHLF1 Neighboring gene apoptosis regulator BHRF1 Neighboring gene nuclear egress lamina protein Neighboring gene DNA packaging protein UL32 Neighboring gene DNA packaging protein UL33 Neighboring gene nuclear egress membrane protein Neighboring gene protein UL49 Neighboring gene nuclear antigen EBNA-1 Neighboring gene small capsid protein Neighboring gene large tegument protein Neighboring gene tegument protein UL37 Neighboring gene multifunctional expression regulator Neighboring gene capsid triplex subunit 1 Neighboring gene ribonucleotide reductase subunit 1 Neighboring gene ribonucleotide reductase subunit 2 Neighboring gene DNA polymerase processivity subunit Neighboring gene envelope protein UL43 Neighboring gene helicase-primase primase subunit Neighboring gene tegument protein UL51 Neighboring gene deoxyuridine triphosphatase Neighboring gene envelope glycoprotein N Neighboring gene virion protein G52 Neighboring gene protein BLLF2 Neighboring gene glycoprotein 350 Neighboring gene envelope glycoprotein 42 Neighboring gene protein Zta Neighboring gene protein Rta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_007605.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An EBNA3A-Mutated Epstein-Barr Virus Retains the Capacity for Lymphomagenesis in a Cord Blood-Humanized Mouse Model. Romero-Masters JC, et al. J Virol, 2020 May 4. PMID 32132242, Free PMC Article
    2. Epstein-Barr Virus (EBV) Latent Protein EBNA3A Directly Targets and Silences the STK39 Gene in B Cells Infected by EBV. Bazot Q, et al. J Virol, 2018 Apr 1. PMID 29367247, Free PMC Article
    3. Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; only the NTD interaction is essential for lymphoblastoid cell growth. Calderwood MA, et al. Virology, 2011 May 25. PMID 21440926, Free PMC Article
    4. Regulation of transactivation function of the aryl hydrocarbon receptor by the Epstein-Barr virus-encoded EBNA-3 protein. Kashuba EV, et al. J Biol Chem, 2006 Jan 13. PMID 16257957
    5. Updated Epstein-Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV. de Jesus O, et al. J Gen Virol, 2003 Jun. PMID 12771413

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An EBNA3A-Mutated Epstein-Barr Virus Retains the Capacity for Lymphomagenesis in a Cord Blood-Humanized Mouse Model.
      Title: An EBNA3A-Mutated Epstein-Barr Virus Retains the Capacity for Lymphomagenesis in a Cord Blood-Humanized Mouse Model.
    2. the polycomb repressor complex is essential for EBNA3A-mediated repression of STK39 Findings in this study provide new insights into the regulation of cellular genes by the transcription factor EBNA3A.
      Title: Epstein-Barr Virus (EBV) Latent Protein EBNA3A Directly Targets and Silences the STK39 Gene in B Cells Infected by EBV.
    3. These results indicate that EBNA3 proteins interact with multiple RBP/CSL domains, but only N-terminal domain interactions are required for lymphoblastoid cell line growth.
      Title: Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; only the NTD interaction is essential for lymphoblastoid cell growth.
    4. EBNA-3 plays a role in facilitating the ligand-dependent AhR activation process
      Title: Regulation of transactivation function of the aryl hydrocarbon receptor by the Epstein-Barr virus-encoded EBNA-3 protein.
    Submit: New GeneRIF Correction

    General gene information

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    regulatory

    • Loc: 11305-11310 regulatory_class = TATA_box
    • Loc: 14352-14357 regulatory_class = TATA_box
    • Loc: 17424-17429 regulatory_class = TATA_box
    • Loc: 20496-20501 regulatory_class = TATA_box
    • Loc: 23568-23573 regulatory_class = TATA_box
    • Loc: 26640-26645 regulatory_class = TATA_box
    • Loc: 29712-29717 regulatory_class = TATA_box
    • Loc: 32784-32789 regulatory_class = TATA_box
    • Loc: 37715-37720 regulatory_class = polyA_signal_sequence
    • Loc: 41471-41476 regulatory_class = TATA_box
    • Loc: 43230-43235 regulatory_class = polyA_signal_sequence
    • Loc: 46544-46549 regulatory_class = TATA_box
    • Loc: 49056-49061 regulatory_class = TATA_box
    • Loc: 49781-49786 regulatory_class = polyA_signal_sequence
    • Loc: 62729-62734 regulatory_class = TATA_box
    • Loc: 63881-63886 regulatory_class = TATA_box
    • Loc: 66516-66521 regulatory_class = TATA_box
    • Loc: 66595-66600 regulatory_class = polyA_signal_sequence
    • Loc: 67552-67557 regulatory_class = TATA_box
    • Loc: 68491-68496 regulatory_class = TATA_box
    • Loc: 68544-68549 regulatory_class = TATA_box
    • Loc: 69892-69897 regulatory_class = polyA_signal_sequence
    • Loc: 74594-74599 regulatory_class = TATA_box
    • Loc: 75311-75316 regulatory_class = polyA_signal_sequence
    • Loc: 76219-76224 regulatory_class = TATA_box
    • Loc: 76575-76580 regulatory_class = TATA_box
    • Loc: 77124-77129 regulatory_class = polyA_signal_sequence
    • Loc: 82933-82938 regulatory_class = polyA_signal_sequence

    rep_origin

    • Loc: 40301-41293

    Repeated regions

    • Loc: 12001-15072 rpt_family = IR1; W , rpt_type = direct
    • Loc: 12001-35355 rpt_family = IR1; W , rpt_type = direct , rpt_unit_range = 12001..15072 (3072 bp)
    • Loc: 15073-18144 rpt_family = IR1; W , rpt_type = direct
    • Loc: 18145-21216 rpt_family = IR1; W , rpt_type = direct
    • Loc: 21217-24288 rpt_family = IR1; W , rpt_type = direct
    • Loc: 24289-27360 rpt_family = IR1; W , rpt_type = direct
    • Loc: 27361-30432 rpt_family = IR1; W , rpt_type = direct
    • Loc: 30433-33504 rpt_family = IR1; W , rpt_type = direct
    • Loc: 33505-35355 rpt_family = IR1; W , rpt_type = direct
    • Loc: 36390-36512 rpt_unit_range = 36390..36398
    • Loc: 37237-37290 rpt_unit_range = 37237..37242
    • Loc: 38290-39827 rpt_family = IR2; NotI , rpt_type = direct , rpt_unit_range = 38290..38414
    • Loc: 40366-41409 rpt_family = DR , rpt_type = direct
    • Loc: 57396-57642 rpt_unit_range = 57396..57446
    • Loc: 58099-58233 rpt_unit_range = 58099..58113
    • Loc: 70031-70173 rpt_unit_range = 70031..70101
    • Loc: 71352-71441 rpt_unit_range = 71352..71360
    • Loc: 77889-78351 rpt_unit_range = 77889..77919
    • Loc: 81920-81989 rpt_family = type A
    • Loc: 81993-82018 rpt_family = type B
    • Loc: 82019-82093 rpt_family = type C
    • Loc: 82098-82123 rpt_family = type B
    • Loc: 82124-82201 rpt_family = type C
    • Loc: 82202-82272 rpt_family = type A
    • Loc: 82283-82360 rpt_family = type C
    • Loc: 82361-82431 rpt_family = type A
    • Loc: 82608-82694 rpt_family = type D
    • Loc: 82695-82781 rpt_family = type D

    variation

    • Loc: 33127-40536
    • Loc: 33356-40162

    General protein information

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    Preferred Names
    nuclear antigen EBNA-3A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_007605.1 Reference assembly

      Range
      11305..82962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_401669.1 nuclear antigen EBNA-3A [Human gammaherpesvirus 4]

      See identical proteins and their annotated locations for YP_401669.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03202, P12977, Q66540, Q69021, Q8AZJ8
      UniProtKB/TrEMBL
      A0A0B6VPX8, A0A0C7TBQ7
      Conserved Domains (2) summary
      PHA03379
      Location:1 → 944
      PHA03379; EBNA-3A; Provisional
      pfam05009
      Location:139 → 384
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
    Nucleotide Protein
    Heading Accession and Version

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