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    CG7882 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35520, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CG7882provided by FlyBase
    Primary source
    FLYBASE:FBgn0033047
    Locus tag
    Dmel_CG7882
    See related
    AllianceGenome:FB:FBgn0033047
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7882
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be integral component of membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in several diseases, including brain disease (multiple); carbohydrate metabolic disorder (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including SLC2A1 (solute carrier family 2 member 1); SLC2A14 (solute carrier family 2 member 14); and SLC2A2 (solute carrier family 2 member 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    42A4-42A4; 2-55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5957621..5960183)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1845126..1847688)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44126 Neighboring gene antisense RNA:CR46269 Neighboring gene long non-coding RNA:CR44127 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth. Kemppainen E, et al. PLoS One, 2016. PMID 26812173, Free PMC Article
    2. Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe. Mattila J, et al. Cell Rep, 2015 Oct 13. PMID 26440885
    3. The Female Post-Mating Response Requires Genes Expressed in the Secondary Cells of the Male Accessory Gland in Drosophila melanogaster. Sitnik JL, et al. Genetics, 2016 Mar. PMID 26746709, Free PMC Article
    4. Updates on ion and water transport by the Malpighian tubule. Dow JAT, et al. Curr Opin Insect Sci, 2021 Oct. PMID 33705976, Free PMC Article
    5. An anti-inflammatory transcriptional cascade conserved from flies to humans. Pavlidaki A, et al. Cell Rep, 2022 Oct 18. PMID 36261018

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hexose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monosaccharide transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7882-PA
    CG7882-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5957621..5960183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136345.2 → NP_610189.2  uncharacterized protein Dmel_CG7882, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610189.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6I4, Q0IGX4
      Conserved Domains (2) summary
      cd06174
      Location:95 → 480
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:43 → 491
      Sugar_tr; Sugar (and other) transporter

    2. NM_165450.3 → NP_724438.1  uncharacterized protein Dmel_CG7882, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724438.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6I4, Q0IGX4
      Related
      FBpp0085319
      Conserved Domains (2) summary
      cd06174
      Location:95 → 480
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:43 → 491
      Sugar_tr; Sugar (and other) transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0IGX4 Q0IGX4

    Gene LinkOut

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