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    PhKgamma Phosphorylase kinase gamma [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32120, updated on 4-Apr-2024

    Summary

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    Official Symbol
    PhKgammaprovided by FlyBase
    Official Full Name
    Phosphorylase kinase gammaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011754
    Locus tag
    Dmel_CG1830
    See related
    AllianceGenome:FB:FBgn0011754
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-sts6; CG1830; Dmel\CG1830; DPhK-gamma; EP779; ESTS:194B3T; PhKg; Phkgamma; phkgamma CES
    Summary
    Predicted to enable phosphorylase kinase activity. Involved in embryonic morphogenesis. Predicted to be part of phosphorylase kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult head; embryonic/larval midgut; extended germ band embryo; and spermatozoon. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease IXc; and liver cirrhosis. Orthologous to several human genes including PHKG2 (phosphorylase kinase catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    10D5-10D5; 1-35 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11695137..11704394)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11589170..11598427)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Valette Neighboring gene bifocal Neighboring gene uncharacterized protein Neighboring gene alpha1,6-fucosyltransferase Neighboring gene mir-9370 stem loop Neighboring gene amun

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DPhK-gamma, a putative Drosophila kinase with homology to vertebrate phosphorylase kinase gamma subunits: molecular characterisation of the gene and phenotypic analysis of loss of function mutants. Bahri SM, et al. Mol Gen Genet, 1994 Dec 1. PMID 7808409
    2. Predicting mutually exclusive spliced exons based on exon length, splice site and reading frame conservation, and exon sequence homology. Pillmann H, et al. BMC Bioinformatics, 2011 Jun 30. PMID 21718515, Free PMC Article
    3. Increased extracellular adenosine in Drosophila that are deficient in adenosine deaminase activates a release of energy stores leading to wasting and death. Zuberova M, et al. Dis Model Mech, 2010 Nov-Dec. PMID 20940317
    4. The Drosophila bifocal gene encodes a novel protein which colocalizes with actin and is necessary for photoreceptor morphogenesis. Bahri SM, et al. Mol Cell Biol, 1997 Sep. PMID 9271427, Free PMC Article
    5. Drosophila Dosage Compensation Loci Associate with a Boundary-Forming Insulator Complex. Kaye EG, et al. Mol Cell Biol, 2017 Nov 1. PMID 28784719, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorylase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorylase kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphorylase kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phosphorylase kinase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphorylase kinase gamma
    Names
    CG1830-PB
    CG1830-PD
    CG1830-PE
    CG1830-PF
    CG1830-PH
    PhKgamma-PB
    PhKgamma-PD
    PhKgamma-PE
    PhKgamma-PF
    PhKgamma-PH
    NP_001285133.1
    NP_001285134.1
    NP_511129.3
    NP_727548.1
    NP_727549.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11695137..11704394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167296.3 → NP_727548.1  phosphorylase kinase gamma, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727548.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961E7
      Related
      FBpp0089045
      Conserved Domains (2) summary
      smart00220
      Location:23 → 291
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14093
      Location:19 → 291
      STKc_PhKG; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit

    2. NM_167297.3 → NP_727549.2  phosphorylase kinase gamma, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727549.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23996, Q7K4Y9, Q9I7D0, Q9VYV7
      Conserved Domains (2) summary
      smart00220
      Location:23 → 291
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14093
      Location:19 → 291
      STKc_PhKG; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit

    3. NM_001298205.1 → NP_001285134.1  phosphorylase kinase gamma, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285134.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961E7
      Conserved Domains (2) summary
      smart00220
      Location:23 → 291
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14093
      Location:19 → 291
      STKc_PhKG; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit

    4. NM_001298204.1 → NP_001285133.1  phosphorylase kinase gamma, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285133.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JEJ4
      Conserved Domains (2) summary
      smart00220
      Location:23 → 291
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14093
      Location:19 → 291
      STKc_PhKG; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit

    5. NM_078574.4 → NP_511129.3  phosphorylase kinase gamma, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511129.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23996, Q7K4Y9, Q9I7D0, Q9VYV7
      Conserved Domains (2) summary
      smart00220
      Location:23 → 291
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14093
      Location:19 → 291
      STKc_PhKG; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961E7 Q961E7
    Q9I7D0 Q9I7D0
    Q9VYV7 Q9VYV7
    X2JEJ4 X2JEJ4

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