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    Eya3 EYA transcriptional coactivator and phosphatase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313027, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Eya3provided by RGD
    Official Full Name
    EYA transcriptional coactivator and phosphatase 3provided by RGD
    Primary source
    RGD:1309932
    See related
    Ensembl:ENSRNOG00000010396 AllianceGenome:RGD:1309932
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity; protein tyrosine phosphatase activity; and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in several processes, including histone dephosphorylation; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of DNA repair. Predicted to act upstream of or within protein dephosphorylation. Located in nucleus. Orthologous to human EYA3 (EYA transcriptional coactivator and phosphatase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 123.6), Thymus (RPKM 108.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q36
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (150090535..150218855)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144806523..144934522)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150833754..150915390)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 Neighboring gene microRNA 3583 Neighboring gene platelet-activating factor receptor Neighboring gene uncharacterized LOC102548282 Neighboring gene U6 spliceosomal RNA Neighboring gene sphingomyelin phosphodiesterase, acid-like 3B Neighboring gene XK related 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent. Krishnan N, et al. J Biol Chem, 2009 Jun 12. PMID 19351884, Free PMC Article
    2. Eyes absent represents a class of protein tyrosine phosphatases. Rayapureddi JP, et al. Nature, 2003 Nov 20. PMID 14628052
    3. Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3. Zhang H, et al. J Biol Chem, 2009 Jan 30. PMID 19008232, Free PMC Article
    4. Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. Ohto H, et al. Mol Cell Biol, 1999 Oct. PMID 10490620, Free PMC Article
    5. Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Cook PJ, et al. Nature, 2009 Apr 2. PMID 19234442, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2AXY142 phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eyes absent homolog 3
    Names
    eyes absent 3 homolog
    NP_001101380.1
    NP_001402793.1
    NP_001402794.1
    XP_006239087.1
    XP_006239088.1
    XP_006239089.1
    XP_038965712.1
    XP_038965714.1
    XP_038965715.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107910.2 → NP_001101380.1  eyes absent homolog 3 isoform 3

      See identical proteins and their annotated locations for NP_001101380.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6ISU4, D3ZHX6
      Conserved Domains (1) summary
      TIGR01658
      Location:239 → 510
      EYA-cons_domain; eyes absent protein conserved domain

    2. NM_001415864.1 → NP_001402793.1  eyes absent homolog 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6AMN9
      Related
      ENSRNOP00000095246.1, ENSRNOT00000097388.1

    3. NM_001415865.1 → NP_001402794.1  eyes absent homolog 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      150090535..150218855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109784.2 → XP_038965712.1  eyes absent homolog 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZ01
      Conserved Domains (2) summary
      TIGR01658
      Location:336 → 607
      EYA-cons_domain; eyes absent protein conserved domain
      pfam05109
      Location:164 → 304
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    2. XM_039109786.2 → XP_038965714.1  eyes absent homolog 3 isoform X3

      UniProtKB/TrEMBL
      D3ZHX6
      Related
      ENSRNOP00000085482.1
      Conserved Domains (2) summary
      TIGR01658
      Location:255 → 526
      EYA-cons_domain; eyes absent protein conserved domain
      cl41773
      Location:83 → 200
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

    3. XM_006239027.5 → XP_006239089.1  eyes absent homolog 3 isoform X3

      UniProtKB/TrEMBL
      D3ZHX6
      Related
      ENSRNOP00000053016.3
      Conserved Domains (2) summary
      TIGR01658
      Location:255 → 526
      EYA-cons_domain; eyes absent protein conserved domain
      cl41773
      Location:83 → 200
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

    4. XM_039109787.2 → XP_038965715.1  eyes absent homolog 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JZ01
      Conserved Domains (2) summary
      TIGR01658
      Location:253 → 524
      EYA-cons_domain; eyes absent protein conserved domain
      pfam05109
      Location:81 → 221
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    5. XM_006239025.5 → XP_006239087.1  eyes absent homolog 3 isoform X2

      See identical proteins and their annotated locations for XP_006239087.1

      UniProtKB/TrEMBL
      A0A0G2JZ01, A0A8I6AMN9
      Conserved Domains (1) summary
      TIGR01658
      Location:301 → 572
      EYA-cons_domain; eyes absent protein conserved domain

    6. XM_006239026.4 → XP_006239088.1  eyes absent homolog 3 isoform X2

      See identical proteins and their annotated locations for XP_006239088.1

      UniProtKB/TrEMBL
      A0A0G2JZ01, A0A8I6AMN9
      Conserved Domains (1) summary
      TIGR01658
      Location:301 → 572
      EYA-cons_domain; eyes absent protein conserved domain
    Nucleotide Protein Strain
    Heading Accession and Version

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