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    BRF1 BRF1 RNA polymerase III transcription initiation factor subunit [ Homo sapiens (human) ]

    Gene ID: 2972, updated on 5-Mar-2024

    Summary

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    Official Symbol
    BRF1provided by HGNC
    Official Full Name
    BRF1 RNA polymerase III transcription initiation factor subunitprovided by HGNC
    Primary source
    HGNC:HGNC:11551
    See related
    Ensembl:ENSG00000185024 MIM:604902; AllianceGenome:HGNC:11551
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BRF; CFDS; hBRF; BRF-1; GTF3B; TAF3C; TAF3B2; TF3B90; TAFIII90; TFIIIB90; HEL-S-76p
    Summary
    This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011]
    Expression
    Ubiquitous expression in fat (RPKM 3.5), brain (RPKM 3.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BRF1 in Genome Data Viewer
    Location:
    14q32.33
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (105209286..105315589, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (99451085..99562978, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105675623..105781926, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105621328-105621926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105629549-105630296 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105633835-105634334 Neighboring gene microRNA 6765 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105636983-105637819 Neighboring gene jagged canonical Notch ligand 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6221 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105658307-105659088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105662217-105662998 Neighboring gene nudix hydrolase 14 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105662999-105663780 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105714496-105715286 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6223 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105716078-105716867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105740537-105741440 Neighboring gene BTB domain containing 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105749364-105749905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105750449-105750989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105752260-105753158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9144 Neighboring gene uncharacterized LOC124903409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6225 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:105778446-105778606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6227 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6228 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105781451-105782102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105789257-105789766 Neighboring gene phosphofurin acidic cluster sorting protein 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105794355-105794864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105798394-105799279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105803897-105804562 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105804563-105805228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105808627-105809468 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:105812556-105812745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105819060-105819589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6230 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:105837257-105837460 Neighboring gene ribosomal protein S20 pseudogene 33 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105856860-105857360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105857361-105857861 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105864965-105865475 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105865476-105865986 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6233 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105877939-105878442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105878443-105878945 Neighboring gene testis expressed 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TFIIB-related factor 1 is a nucleolar protein that promotes RNA polymerase I-directed transcription and tumour cell growth. Wang J, et al. Hum Mol Genet, 2023 Jan 1. PMID 35925837
    2. A novel BRF1 mutation in two middle-aged siblings with cerebellofaciodental syndrome. Zhao X, et al. Chin Med J (Engl), 2022 Oct 5. PMID 34935685, Free PMC Article
    3. Cerebellofaciodental syndrome in an adult patient: Expanding the phenotypic and natural history characteristics. Honjo RS, et al. Am J Med Genet A, 2021 May. PMID 33645901
    4. Expanding the phenotype of cerebellar-facial-dental syndrome: Two siblings with a novel variant in BRF1. Valenzuela I, et al. Am J Med Genet A, 2020 Nov. PMID 32896090
    5. Alcohol Intake and Abnormal Expression of Brf1 in Breast Cancer. Huang C, et al. Oxid Med Cell Longev, 2019. PMID 31781337, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel BRF1 mutation in two middle-aged siblings with cerebellofaciodental syndrome.
      Title: A novel BRF1 mutation in two middle-aged siblings with cerebellofaciodental syndrome.
    2. TFIIB-related factor 1 is a nucleolar protein that promotes RNA polymerase I-directed transcription and tumour cell growth.
      Title: TFIIB-related factor 1 is a nucleolar protein that promotes RNA polymerase I-directed transcription and tumour cell growth.
    3. tRNA biogenesis and specific aminoacyl-tRNA synthetases regulate senescence stability under the control of mTOR.
      Title: tRNA biogenesis and specific aminoacyl-tRNA synthetases regulate senescence stability under the control of mTOR.
    4. Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches.
      Title: Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches.
    5. Cerebellofaciodental syndrome in an adult patient: Expanding the phenotypic and natural history characteristics.
      Title: Cerebellofaciodental syndrome in an adult patient: Expanding the phenotypic and natural history characteristics.
    6. Expanding the phenotype of cerebellar-facial-dental syndrome: Two siblings with a novel variant in BRF1.
      Title: Expanding the phenotype of cerebellar-facial-dental syndrome: Two siblings with a novel variant in BRF1.
    7. The transcription factor Sp1 modulates RNA polymerase III gene transcription by controlling BRF1 and GTF3C2 expression in human cells.
      Title: The transcription factor Sp1 modulates RNA polymerase III gene transcription by controlling BRF1 and GTF3C2 expression in human cells.
    8. BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration.
      Title: BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration.
    9. Runx2 mediates the deregulation of Brf1 and Pol III genes and its abnormal expression predicts the worse prognosis of breast cancer.
      Title: The significance of Runx2 mediating alcohol-induced Brf1 expression and RNA Pol III gene transcription.
    10. Recent studies have demonstrated that Brf1 is overexpressed in most ER+ (estrogen receptor positive) cases of breast cancer and the change in cellular levels of Brf1 reflects the therapeutic efficacy and prognosis of this disease. It suggests that Brf1 may be a potential diagnosis biomarker and a therapeutic target of alcohol-associated breast cancer.
      Title: Alcohol Intake and Abnormal Expression of Brf1 in Breast Cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Cerebellar-facial-dental syndrome
    MedGen: C4015495 OMIM: 616202 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    New gene functions in megakaryopoiesis and platelet formation.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ42674, FLJ43034, MGC105048

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase III general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase III type 3 promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in tRNA transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase III promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in transcription preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIIB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIIB complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of transcription preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor IIIB 90 kDa subunit
    Names
    B - related factor 1
    BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB
    BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
    TATA box binding protein (TBP)-associated factor 3C
    TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 2
    TBP - associated factor, RNA polymerase III, 90kD
    epididymis secretory sperm binding protein Li 76p
    general transcription factor IIIB, 90kD subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029489.1 RefSeqGene

      Range
      19577..111292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001242786.2 → NP_001229715.1  transcription factor IIIB 90 kDa subunit isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant (1). The resulting isoform (4) is shorter at the N-terminus and contains an insert compared to isoform 1.
      Source sequence(s)
      AK294899, AL512355, BC071637
      Consensus CDS
      CCDS55951.1
      UniProtKB/Swiss-Prot
      Q92994
      Related
      ENSP00000388877.3, ENST00000440513.7
      Conserved Domains (2) summary
      COG1405
      Location:1 → 151
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      pfam07741
      Location:335 → 453
      BRF1; Brf1-like TBP-binding domain

    2. NM_001242787.2 → NP_001229716.1  transcription factor IIIB 90 kDa subunit isoform 5

      See identical proteins and their annotated locations for NP_001229716.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant (1). The resulting isoform (5) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK294899, AK295579, AL512355, BC071637
      Consensus CDS
      CCDS55950.1
      UniProtKB/Swiss-Prot
      Q92994
      Related
      ENSP00000329029.3, ENST00000327359.7
      Conserved Domains (3) summary
      pfam07741
      Location:335 → 431
      BRF1; Brf1-like TBP-binding domain
      cd20553
      Location:1 → 59
      CYCLIN_TFIIIB90_rpt1; first cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins
      cd20554
      Location:64 → 155
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins

    3. NM_001242788.2 → NP_001229717.1  transcription factor IIIB 90 kDa subunit isoform 6

      See identical proteins and their annotated locations for NP_001229717.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL512355, BC016743, BC071637, BC086856, BX440529
      Consensus CDS
      CCDS55952.1
      UniProtKB/Swiss-Prot
      Q92994
      Related
      ENSP00000369269.2, ENST00000379937.6
      Conserved Domains (2) summary
      COG1405
      Location:4 → 239
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      pfam07741
      Location:423 → 519
      BRF1; Brf1-like TBP-binding domain

    4. NM_001242789.2 → NP_001229718.1  transcription factor IIIB 90 kDa subunit isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant (1). The resulting isoform 7 is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK096471, BC071637, BC086856
      Consensus CDS
      CCDS55949.1
      UniProtKB/Swiss-Prot
      Q92994
      Related
      ENSP00000389859.2, ENST00000446501.6
      Conserved Domains (1) summary
      pfam07741
      Location:212 → 308
      BRF1; Brf1-like TBP-binding domain

    5. NM_001242790.2 → NP_001229719.1  transcription factor IIIB 90 kDa subunit isoform 8

      See identical proteins and their annotated locations for NP_001229719.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (8) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL512355, BC016743, BX440529, N91109
      Consensus CDS
      CCDS55953.1
      UniProtKB/TrEMBL
      V9HVY2
      Related
      ENSP00000446707.1, ENST00000548421.2
      Conserved Domains (1) summary
      COG1405
      Location:4 → 162
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]

    6. NM_001519.4 → NP_001510.2  transcription factor IIIB 90 kDa subunit isoform 1

      See identical proteins and their annotated locations for NP_001510.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL512355, BC016743, BC071637, BX440529, U75276
      Consensus CDS
      CCDS10001.1
      UniProtKB/Swiss-Prot
      B3KU36, B4DIG5, B7Z2N3, F5H5Z7, F8WA46, Q13223, Q3SYD9, Q5PR24, Q6IQ02, Q92994, Q96KX3, Q9HCW6, Q9HCW7, Q9HCW8
      Related
      ENSP00000448387.2, ENST00000547530.7
      Conserved Domains (2) summary
      COG1405
      Location:4 → 266
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      pfam07741
      Location:450 → 546
      BRF1; Brf1-like TBP-binding domain

    7. NM_145685.3 → NP_663718.1  transcription factor IIIB 90 kDa subunit isoform 3

      See identical proteins and their annotated locations for NP_663718.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant (1). The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AJ297407, AL512355, BC071637
      Consensus CDS
      CCDS42001.1
      Related
      ENSP00000376340.4, ENST00000392557.8
      Conserved Domains (2) summary
      pfam07741
      Location:246 → 342
      BRF1; Brf1-like TBP-binding domain
      cd20554
      Location:1 → 66
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      105209286..105315589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431305.1 → XP_047287261.1  transcription factor IIIB 90 kDa subunit isoform X7

    2. XM_047431304.1 → XP_047287260.1  transcription factor IIIB 90 kDa subunit isoform X6

    3. XM_047431302.1 → XP_047287258.1  transcription factor IIIB 90 kDa subunit isoform X4

    4. XM_011536673.3 → XP_011534975.1  transcription factor IIIB 90 kDa subunit isoform X3

      Conserved Domains (4) summary
      COG1405
      Location:4 → 216
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      cd00043
      Location:93 → 170
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      pfam07741
      Location:404 → 496
      BRF1; Brf1-like TBP-binding domain
      pfam08271
      Location:4 → 43
      TF_Zn_Ribbon; TFIIB zinc-binding

    5. XM_005267561.5 → XP_005267618.1  transcription factor IIIB 90 kDa subunit isoform X1

      See identical proteins and their annotated locations for XP_005267618.1

      Conserved Domains (5) summary
      COG1405
      Location:4 → 266
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      cd00043
      Location:93 → 170
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      pfam07741
      Location:453 → 545
      BRF1; Brf1-like TBP-binding domain
      pfam08271
      Location:4 → 43
      TF_Zn_Ribbon; TFIIB zinc-binding
      cl00050
      Location:187 → 260
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    6. XM_047431303.1 → XP_047287259.1  transcription factor IIIB 90 kDa subunit isoform X5

    7. XM_047431310.1 → XP_047287266.1  transcription factor IIIB 90 kDa subunit isoform X12

    8. XM_047431308.1 → XP_047287264.1  transcription factor IIIB 90 kDa subunit isoform X11

    9. XM_047431307.1 → XP_047287263.1  transcription factor IIIB 90 kDa subunit isoform X9

    10. XM_047431306.1 → XP_047287262.1  transcription factor IIIB 90 kDa subunit isoform X8

    11. XM_024449553.2 → XP_024305321.1  transcription factor IIIB 90 kDa subunit isoform X13

      Conserved Domains (1) summary
      pfam07741
      Location:212 → 308
      BRF1; Brf1-like TBP-binding domain

    12. XM_005267563.5 → XP_005267620.1  transcription factor IIIB 90 kDa subunit isoform X10

      See identical proteins and their annotated locations for XP_005267620.1

      Conserved Domains (2) summary
      pfam07741
      Location:246 → 342
      BRF1; Brf1-like TBP-binding domain
      cd20554
      Location:1 → 66
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins

    13. XM_047431311.1 → XP_047287267.1  transcription factor IIIB 90 kDa subunit isoform X14

    14. XM_011536672.4 → XP_011534974.1  transcription factor IIIB 90 kDa subunit isoform X2

      Conserved Domains (5) summary
      COG1405
      Location:4 → 266
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      cd00043
      Location:93 → 170
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      pfam07741
      Location:454 → 546
      BRF1; Brf1-like TBP-binding domain
      pfam08271
      Location:4 → 43
      TF_Zn_Ribbon; TFIIB zinc-binding
      cl00050
      Location:187 → 260
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      99451085..99562978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375914.1 → XP_054231889.1  transcription factor IIIB 90 kDa subunit isoform X7

    2. XM_054375913.1 → XP_054231888.1  transcription factor IIIB 90 kDa subunit isoform X6

    3. XM_054375911.1 → XP_054231886.1  transcription factor IIIB 90 kDa subunit isoform X4

    4. XM_054375910.1 → XP_054231885.1  transcription factor IIIB 90 kDa subunit isoform X3

    5. XM_054375908.1 → XP_054231883.1  transcription factor IIIB 90 kDa subunit isoform X1

    6. XM_054375912.1 → XP_054231887.1  transcription factor IIIB 90 kDa subunit isoform X5

    7. XM_054375918.1 → XP_054231893.1  transcription factor IIIB 90 kDa subunit isoform X11

    8. XM_054375915.1 → XP_054231890.1  transcription factor IIIB 90 kDa subunit isoform X8

    9. XM_054375919.1 → XP_054231894.1  transcription factor IIIB 90 kDa subunit isoform X12

    10. XM_054375916.1 → XP_054231891.1  transcription factor IIIB 90 kDa subunit isoform X9

    11. XM_054375920.1 → XP_054231895.1  transcription factor IIIB 90 kDa subunit isoform X13

    12. XM_054375917.1 → XP_054231892.1  transcription factor IIIB 90 kDa subunit isoform X10

    13. XM_054375921.1 → XP_054231896.1  transcription factor IIIB 90 kDa subunit isoform X14

    14. XM_054375909.1 → XP_054231884.1  transcription factor IIIB 90 kDa subunit isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145696.1: Suppressed sequence

      Description
      NM_145696.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92994.1 GenPept UniProtKB/Swiss-Prot:Q92994

    Gene LinkOut

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