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    DBT dihydrolipoamide branched chain transacylase E2 [ Bos taurus (cattle) ]

    Gene ID: 280759, updated on 3-Apr-2024

    Summary

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    Official Symbol
    DBTprovided by VGNC
    Official Full Name
    dihydrolipoamide branched chain transacylase E2provided by VGNC
    Primary source
    VGNC:VGNC:27896
    See related
    BGD:BT29559; Ensembl:ENSBTAG00000006320
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    E2; E2b; BCKADE2; BCKAD-E2
    Orthologs
    human mouse all
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    Genomic context

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    See DBT in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (43039359..43079909)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene high mobility group protein B1-like Neighboring gene RNA 3'-terminal phosphate cyclase Neighboring gene AT-rich interactive domain-containing protein 3A-like Neighboring gene leucine rich repeat containing 39 Neighboring gene tRNA methyltransferase 13 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain alpha-ketoacid dehydrogenase complex. Kato M, et al. EMBO J, 2006 Dec 13. PMID 17124494, Free PMC Article
    2. Characterization and conservation of the inner E2 core domain structure of branched-chain alpha-keto acid dehydrogenase complex from bovine liver. Construction of a cDNA encoding the entire transacylase (E2b) precursor. Griffin TA, et al. J Biol Chem, 1988 Oct 5. PMID 3049570
    3. Nucleotide sequence of a cDNA for branched chain acyltransferase with analysis of the deduced protein structure. Hummel KB, et al. J Biol Chem, 1988 May 5. PMID 3245861
    4. Conservation of primary structure in the lipoyl-bearing and dihydrolipoyl dehydrogenase binding domains of mammalian branched-chain alpha-keto acid dehydrogenase complex: molecular cloning of human and bovine transacylase (E2) cDNAs. Lau KS, et al. Biochemistry, 1988 Mar 22. PMID 2837277
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This gating mechanism synchronizes the binding of the two substrates to the active-site channel, which serves as a feed-forward switch to coordinate the E2b-catalyzed acyltransfer reaction.
      Title: A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain alpha-ketoacid dehydrogenase complex.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables lipoic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
    Names
    BCKAD E2 subunit
    branched-chain alpha-keto acid dehydrogenase complex component E2
    component of branched chain keto acid dehydrogenase complex
    dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex
    dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
    NP_776330.1
    XP_024840220.1
    XP_024840222.1
    XP_059737414.1
    XP_059737418.1
    XP_059737419.1
    XP_059737423.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173905.2 → NP_776330.1  lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor

      See identical proteins and their annotated locations for NP_776330.1

      Status: PROVISIONAL

      Source sequence(s)
      M21572
      UniProtKB/Swiss-Prot
      A7YWE9, P11181
      UniProtKB/TrEMBL
      A0A3Q1MED4
      Related
      ENSBTAP00000008292.5, ENSBTAT00000008292.7
      Conserved Domains (4) summary
      cd06849
      Location:65 → 138
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      PLN02528
      Location:67 → 482
      PLN02528; 2-oxoisovalerate dehydrogenase E2 component
      pfam00198
      Location:267 → 479
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
      pfam02817
      Location:172 → 205
      E3_binding; e3 binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      43039359..43079909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059881431.1 → XP_059737414.1  lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial isoform X2

      Related
      ENSBTAP00000077005.1, ENSBTAT00000120804.1

    2. XM_024984452.2 → XP_024840220.1  lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MED4
      Related
      ENSBTAP00000075187.1, ENSBTAT00000131760.1
      Conserved Domains (1) summary
      cl27351
      Location:117 → 532
      E3_binding; e3 binding domain

    3. XM_024984454.2 → XP_024840222.1  lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl27351
      Location:117 → 468
      E3_binding; e3 binding domain

    4. XM_059881436.1 → XP_059737419.1  lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial isoform X4

    5. XM_059881435.1 → XP_059737418.1  lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial isoform X4

    6. XM_059881440.1 → XP_059737423.1  lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11181.2 GenPept UniProtKB/Swiss-Prot:P11181

    Gene LinkOut

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