Official Symbol

MOCS3provided by HGNC

Official Full Name

molybdenum cofactor synthesis 3provided by HGNC

Primary Source

HGNC:15765

See related

Ensembl:ENSG00000124217; HPRD:10092; MIM:609277

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

UBA4; MGC9252; dJ914P20.3; MOCS3

Summary

Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. One of the enzymes required for the biosynthesis of MoCo is molybdopterin synthase (MPT synthase). The protein encoded by this gene adenylates and activates MPT synthase. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. [provided by RefSeq]

(plus) Go to reference sequence detailsTry our new Sequence Viewer

Preferred Names

molybdenum cofactor synthesis 3

Names

molybdenum cofactor synthesis 3

MPT synthase sulfurylase

molybdopterin synthase sulfurylase

ubiquitin-like modifier activating enzyme 4

UBA4, ubiquitin-activating enzyme E1 homolog

NP_055299.1

EC 2.7.7.-

EC 2.8.1.-

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

1. NG_008923.1 RefSeqGene

   Range

   2240..4697, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

mRNA and Protein(s)

1. NM_014484.3 → NP_055299.1  molybdenum cofactor synthesis 3

   Source sequence(s)

   BC015939,BG105185

   Consensus CDS

   CCDS13435.1

   UniProtKB/Swiss-Prot

   O95396

   Conserved Domains (3) summary

   cd01526
   Location:327 – 460
   Blast Score: 417

   RHOD_ThiF; Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis...

   cd00757
   Location:62 – 290
   Blast Score: 606

   ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...

   PRK07411
   Location:55 – 460
   Blast Score: 738

   PRK07411; hypothetical protein; Validated

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

1. NC_000020.10

   Range

   49575362..49577819

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NT_011362.10 

   Range

   19771454..19773911

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

1. AC_000063.1

   Range

   46279622..46282079

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_927339.1 

   Range

   19782731..19785188

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

1. AC_000152.1

   Range

   46323933..46326390

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_001838666.1 

   Range

   12644782..12647239

   Download

   GenBank FASTA Sequence Viewer (Graphics)