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1: F8 coagulation factor VIII, procoagulant component [ Homo sapiens ]

GeneID: 2157 updated 8-Nov-2009

[Top][Help]Summary

Official Symbol
F8provided by HGNC
Official Full Name
coagulation factor VIII, procoagulant componentprovided by HGNC
Primary Source
HGNC:3546
Locus Tag
RP11-115M6.7
See related
Ensembl:ENSG00000185010; HPRD:02384; MIM:306700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AHF; F8B; F8C; HEMA; FVIII; DXS1253E; F8
Summary
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq]

[Top][Help]Genomic regions, transcripts, and products

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. Case Report: Haemophilia A in two unrelated females due to F8 gene inversions combined with skewed inactivation of X chromosome.
PubMed 2. L-arginine increases expression of human FVIII gene in HUVEC through enhancing its transcription.
PubMed 3. The ability of blood outgrowth endothelial cells to store a significant portion of synthesized FVIII-GFP in Weibel-Palade bodies provide an attractive cellular on-demand delivery device for gene therapy of hemophilia A.
PubMed 4. FVII hypercoagulant activity levels in diabetes mellitus is not associated with obesity, leptin levels or insulin resistance, but is associatted with hypertriglyceridemia.
PubMed 5. Data suggest that populations of proteolytic anti-Factor VIII IgG in acquired hemophilia patients are different from that of inhibitor-positive hemophilia A patients.
PubMed 6. Factor 8 (F8) gene mutation profile of Turkish hemophilia A patients with inhibitors.
PubMed 7. The risk of extra-hepatic portal vein obstruction increased with increasing factor VIII levels and was only partially dependent on the acute phase reaction.
PubMed 8. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
PubMed 9. Report gene transfer to hemophilia A mice via oral delivery of FVIII-chitosan nanoparticles.
PubMed 10. Suggest that haplotyping of factor VIII gene determines better prognosis in the direction of indirect genetic analysis of hemophilia A.
PubMed 11. Novel causative mutation V197G of Factor VIII which could be detected neither in the neonate nor in his mother which accounted for hemophilia A.
PubMed 12. the spectrum of mutations of the F8 gene in Lebanese patients with haemophilia A; 21 are novel.
PubMed 13. Results suggest that anti-FVIII Abs share a pattern of antigen specificity and that exposed regions of the FVIII molecule that form functionally important binding sites elicit an intense Ab response.
PubMed 14. A family with combined point mutations of the hemophilia A (F8)and X-linked adrenoleukodystrophy (ABCD1) genes.
PubMed 15. heavy chain cleavages during thrombin-catalyzed activation of factor VIII are influenced by cleavage at Arg 1689
PubMed 16. Identification of plasmin-interactive sites in the light chain of factor VIII responsible for proteolytic cleavage at Lys36.
PubMed 17. residues 2228-2240 in the factor VIIIa C2 domain constitutes an interactive site for the Gla domain of factor IXa. The findings provide the first evidence for an essential role for this interaction in factor Xase assembly
PubMed 18. Markers of inflammation (factor VIIIc, von Willebrand factor, white blood cell count) and hemostasis are associated with greater risk of kidney function decrease.
PubMed 19. Data show that seven hemophilia A patients showed F8 gene inversion mutation in thirty-one patients. Three in four mothers of HA patients with intron 22 inversion mutation were diagnosed as carriers.
PubMed 20. inhibitory effect of VWF added decreased with decreasing rFVIII concentration in FVIII/VWF-depleted substrate plasma
PubMed 21. Altered bioavailability of platelet-derived factor VIII during thrombocytosis reverses phenotypic efficacy in haemophilic mice.
PubMed 22. Examine correlation between von Willebrand factor antigen, von Willebrand factor ristocetin cofactor activity and factor VIII activity in plasma.
PubMed 23. nine of 80 prescreened hemophilia A patients showed large duplications of one or more exons
PubMed 24. review of intron 22 inversions
PubMed 25. Positively charged K466, R471, R489 & R490, & hydrophilic residues Y487 & S488 form the frame of the consensus binding site of F8 with megalin, LDLR and VLDLR. Binding requires dissociation of F8 from von Willebrand factor and is activation sensitive.
PubMed 26. VWF may reduce the immunogenicity of FVIII by inhibiting the uptake of FVIII by antigen presenting cells
PubMed 27. The c.3780C > G (p.D1260E) change was over-represented among mild mild hemophilia A patients in whom the genetic analyses of the F8 gene failed to detect a pathological mutation.
PubMed 28. Results deascribe the chromosomal localization of the human Factor VIII transgene in F2 and F3 generations of transgenic rabbits using FISH-TSA.
PubMed 29. identification of 38 new genetic alterations in severe and moderate hemophilia A
PubMed 30. The F8 C2 epitope groups recognized by 26 polyclonal human anti-fVIII inhibitor plasmas were identified
PubMed 31. there are associations between several AQP2 SNPs and the risk of venous thrombosis, and weak associations with arterial blood pressure, but not with plasma levels of VWF propeptide, VWF or FVIII
PubMed 32. An observational study of sucrose-formulated recombinant factor VIII for Japanese patients with haemophilia A.
PubMed 33. Greater plasma fibrinogen and, to some degree, von Willebrand factor were associated with increased rates of hemorrhagic stroke in these prospective studies, whereas Factor VIII was related to it in younger ARIC study participants only
PubMed 34. study identified a recurrent F8 gene mutation in Irish haemophilia A patients; the same missense point mutation, c.1649 G>A in exon 11, was identified in 13 of 69 (18.8%) kindreds; all 13 individuals were found to have an identical F8 gene haplotype
PubMed 35. Describe an immunoassay for simultaneous detection and epitope mapping of anti-factor VIII antibodies.
PubMed 36. factor VIIIa is inactivated by activated protein C in the presence of its cofactors, protein S and factor V
PubMed 37. An extended Cryo-electron microscopy study to follow the factor VIII binding to phosphatidylserine containing lipid nanotubes at different lipid composition was undertaken.
PubMed 38. FVIII plays a role in regulating proteolytic processing of von Willebrand factor (VWF) by ADAMTS13 under shear stress, which depends on the high-affinity interaction between FVIII and its carrier protein, VWF.
PubMed 39. Structural model provides insight into the activation of factor VIII and the interaction of factor VIIIa with factor IXa on the membrane surface.
PubMed 40. Electrophilic-FVIII is a prototype reagent able to attain irreversible and specific inactivation of pathogenic antibodies.
PubMed 41. analysis of the residues contributing to A2 domain-dependent structural stability in factor VIII and factor VIIIa
PubMed 42. a novel G-to-A mutation in intron 10 of the F8 gene is a putative cause of mild hemophilia A in southern Italy.
PubMed 43. Persistent factor VIII-dependent factor X activation on endothelial cells is independent of von Willebrand factor
PubMed 44. Unreported mutations are distributed throughout the F8 gene and they affected all F8 exons but exon 20 in Italian hemophilia a patients.
PubMed 45. study reports 4 individuals with the Tyr346-->Cys mutation; mean FVIII:C1 level was 25 IU dL(-1) compared with a mean FVIII:C2 level of 63 IU dL(-1); these individuals presented opportunistically & did not have a clinically significant bleeding disorder
PubMed 46. the binding sites for VLDLR (very low density lipoprotein receptor) and LRP (low-density lipoprotein receptor-related protein) within Factor VIII overlap and the A2 site becomes exposed upon physiological activation of Factor VIII.
PubMed 47. Mapped factor VIII B-cell epitopes recognized by monoclonal antibody ESH8.
PubMed 48. Identification of 31 novel mutations in the F8 gene in Spanish hemophilia A patients: structural analysis of 20 missense mutations suggests new intermolecular binding sites.(
PubMed 49. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
PubMed 50. CD91 and other members of the LDL receptor family are not strongly implicated in FVIII internalization by monocyte-derived dendritic cells
PubMed 51. Increased levels of Factor VIII occurred in the precursors of cardiac myocytes, smooth muscle and endothelial cells in normal and post-ischemic hearts.
PubMed 52. Using FVIII-deficient plasma as a model of reduced thrombin generation, we demonstrate that low antithrombin levels enhance in vitro hemostatic responses to rFVIIa.
PubMed 53. we have found that F8 gene large deletions are likely to be a high risk factor also for immunetolerance therapy unresponsiveness, while no clear evidence has been demonstrated for other mutation types.
PubMed 54. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
PubMed 55. Observational study of genotype prevalence and genetic testing. (HuGE Navigator)
PubMed 56. Observational study of genetic testing. (HuGE Navigator)
PubMed 57. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
PubMed 58. Observational study of gene-disease association. (HuGE Navigator)
PubMed 59. Observational study of genotype prevalence. (HuGE Navigator)
PubMed 60. Epitope mapping for a variety of F8 antibodies reveal epitope sites that bind lipids, sites that are linked to F8 activation by either thrombin or FXa, and sites that bind VWF
PubMed 61. Two haplotypes in FVIII and one in FXIIIa1 were significantly associated with increased ischemic stroke risk
PubMed 62. causative mutation of hemophilia A is -219C>T in the promoter region and is found in a family pedigree
PubMed 63. A2 domain of factor VIII interacts with low-density lipoprotein-related proteins via multiple binding sites.
PubMed 64. Demonstrate the efficacy and safety of sucrose formulated recombinant FVIII during normal clinical use in the treatment of patients with severe haemophilia A.
PubMed 65. Cathepsin G from neutrophils and monocytes may provide some pro-coagulant effect by activating FVIII.
PubMed 66. the C1 domain of FVIII contributes to platelet-binding affinity
PubMed 67. asymptomatic individuals with elevated FVIII:c levels and a positive family history of VTE or arterial vascular events before the age of 50 appear to have a high annual incidence of first VTE and arterial vascular events.
PubMed 68. hereditary haemorrhagic telangiectasia (HHT)-related elevation of FVIII:Ag levels may influence thrombotic risk in HHT
PubMed 69. Factor VIII-specific memory B cells are absent or present at low levels in patients with hemophilia A who have been successfully treated with immune tolerance induction
PubMed 70. FVIII trafficking to WPBs is independent of Tyr1680 and high-affinity binding to VWF; the structural requirements that determine intracellular co-trafficking differ from those that determine complex assembly in circulation.
PubMed 71. plasma-derived FVIII induces lower levels of inhibitors than rFVIII, and that VWF is an immuno-chaperone molecule for FVIII
PubMed 72. Duplications involving int22h-1 of the factor VIII gene may mask point mutations in hemophilia A
PubMed 73. During the second and third gestation trimesters a significant increase (P < 0.05) in FVIII and VWF:Ag levels and a decrease in FPS levels were seen compared with the first trimester.
PubMed 74. 28 new mutations of factor VIII are described, among 109 Andalusian hemophilia A patients.
PubMed 75. Used FVIII-deficient plasma to detect FVIII-dependent activated protein resistance.
PubMed 76. when the domain-deleted vWF-lentiviruses were transduced into K562 cells, the vEx28 increased the activity of the secreted FVIII compared to what was observed with vEx52.
PubMed 77. data from this study suggest that the spectrum of factor VIII gene defects in Korean patients with haemophilia A is as heterogeneous as reported in other populations
PubMed 78. study found 10 novel mutations in Albanian patients with haemophilia A: 4 null mutations in severe haemophilia A (Gln1090X, Cys1832X, 2374delT, 5676insT) & 6 missense mutations (Ile76Thr, Leu299Pro, Asp525Glu, Cys692Tyr, His1755Leu & Trp1835Cys)
PubMed 79. inversion with concomitant deletion and insertion events in the coagulation factor VIII gene may be a mechanism for X-chromosomal rearrangements causing hemophilia A
PubMed 80. A total of 47 different hemophilia A causative FVIII mutations have been identified, 26 of which are described for the first time.
PubMed 81. the relationship between ischemic stroke and increased factor VIII levels in children is doubtful.
PubMed 82. occurrence of high levels associated with stroke in a 5-year old girl
PubMed 83. Competitive ELISAs suggested that F2200 plays a more important role in both phospholipid-binding and vWF-binding than N2198 and M2199.
PubMed 84. The binding activity of the C-C2 domain to PS-containing phospholipid vesicles was measured, showing that the C2 domain alone does not have full membrane binding activity, and that the other light chain domains, A3 and/or C1, are also involved.
PubMed 85. Eleven pathological changes in the factor VIII sequence detected in male patients with haemophilia A or in female obligate carriers.
PubMed 86. elevated plasma FVIII levels in liver cirrhosis are associated with increased hepatic biosynthesis of VWF and decreased expression of LRP, rather than increased FVIII synthesis
PubMed 87. Molecular modeling suggested mechanisms by which substitutions at residues 382 and 569, located outside the proposed FIXa-binding region, may influence FVIII/FIXa interaction. His2155 was predicted to participate in FVIII/VFW binding.
PubMed 88. review of role of factor VIIIa to markedly increase the catalytic efficiency of factor IXa in the activation of factor X
PubMed 89. REVIEW: Molecular defects in coagulation Factor VIII and their impact on Factor VIII function.
PubMed 90. The activation of procofactor VIII to factor VIIIa increases the affinity of binding to platelets of both factor VIIIa and factor X.
PubMed 91. elevated levels of FVIII:C put patients at increased risk for both venous and arterial thrombosis
PubMed 92. Lungs from heart-beating donors who were declined for transplantation were perfused and ventilated in an isolated reperfusion model for 2 hours. A progressive accumulation of FVIII and von Willebrand factor (VWF) was recorded in the perfusion medium.
PubMed 93. neither FVIII, thrombin-activated FVIII, VWF nor a complex of FVIII and VWF modulate the maturation of human dendritic cells or their capacity to stimulate autologous or allogeneic T cells
PubMed 94. Addition of von Willebrand factor//factor VIII complex increased platelet adhesion to the collagen surface in platelet-reduced blood plattelets to normal levels.
PubMed 95. Cofactor activities of factor VIIIa and A2 subunit following cleavage of A1 subunit at Arg336
PubMed 96. mutations in the F8 gene have roles in severe hemophilia A
PubMed 97. the factor XIII Val34Leu mutation is dependent on fibrinogen for its preventive effect in deep venous thrombosis
PubMed 98. factor VIII has a Ca2+ binding site required for cofactor activity in the A1 domain
PubMed 99. results support the common FVHR2 as a possible independent determinant of FVIII:c levels, the relationship between factor V and factor VIII levels, and the hypothesis of a mild prothrombotic role of FVHR2 by means of increased factor VIII levels
PubMed 100. Heteroduplex screening identified 74 small mutations in the F8 genes of 72 families with hemophilia A. In 24 families, at least one affected member had an alloimmune response to F8: of these, 11 were associated with missense mutations.
PubMed 101. Large gene rearrangements of introns of the factor VIII gene in severe hemophilia A.
PubMed 102. The intron 1 factor VIII gene inversion was found in 1 of 20 in a population of Italian hemophilia A patients.
PubMed 103. The factor VIII gene intron 1 inversion mutation: prevalence in severe hemophilia A patients in the UK.
PubMed 104. high FVIII levels in venous thromboembolism represent a complex trait caused by several genetic factors.
PubMed 105. Increased cofactor specific activity observed for factor VIII with a calcium ion-binding site Glu113Ala mutation may result from its enhanced affinity for factor IXa on the physiological membrane.
PubMed 106. the association between Val34Leu polymorphism and coronary artery disease (Meta-Analysis)
PubMed 107. demonstrate that entry of FVIII into human dendritic cells (DC) leading to T cell activation, is mediated by mannose-terminating glycans on FVIII
PubMed 108. hemophilic mutations across the factor VIII C2 domain have variable effects on stability and von Willebrand Factor-binding activities
PubMed 109. analysis of FVIII mutations in haemophilia A patients
PubMed 110. elevated factor (F)VIII:C plasma levels are a risk factor for early recurrent miscarriages
PubMed 111. Factor VIIIc may play a role in the development of venous thromboembolism in factor V Leiden carriers
PubMed 112. LMAN1 and MCFD2 form a cargo receptor complex and the primary sorting signals residing in the B domain direct the binding of factor VIII
PubMed 113. high levels of coagulation FXI, FIX and FVIII are related to risk of inherited thrombophilia syndrome
PubMed 114. review of the response of T- and B-cells to transfused Factor VIII, epitope mapping, and the mechanism of inhibition of F8 by alloantibodies
PubMed 115. Effect of deficiency on generation of thrombin
PubMed 116. Mutations associated with hemophilia A in the 558-565 loop of the factor VIIIa A2 subunit alter the catalytic activity of the factor Xase complex.
PubMed 117. Mutagenecity studies suggests that the entire tightly packed hydrophobic core within the predicted pseudo-threefold axis contributes to stabilization of FVIIIa.
PubMed 118. results point to the presence of still unknown factor(s) causing hemophilia A, which might be either allelic or in the close proximity of the F8 gene or non-allelic associated with other genetic loci that are involved in the processing of the F8 protein.
PubMed 119. asparagine-linked oligosaccharide structures of the FVIII B domain recognize the carbohydrate recognition domains of ASGPR and an ASOR-sensitive mechanism, most likely ASGPR, contributes to the catabolism of coagulation FVIII in vivo.
PubMed 120. review of protein structure and effect of factor VIII [review]
PubMed 121. a missense mutation in factor VIII gene may have a role in hemophilia A diagnosed in a female with Swyer syndrome [case report]
PubMed 122. A deletion of Ala2201 (Del2201) was identified in the FVIII C2 domain of 2 unrelated patients with mild hemophilia A. This mutation prevents FVIII binding to a human monoclonal antibody recognizing the C2 domain.
PubMed 123. Fourteen of the 21 females were confirmed to be carriers.
PubMed 124. Results show that factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high-titer inhibitory antibodies.
PubMed 125. Comparison of the prevalence of high FVIIIc levels in pediatric stroke patients and healthy subjects with and without FVL/PT 20210 indicated that high FVIII levels are an independent risk factor.
PubMed 126. Ten representative three-dimensional models of the FVIIIa-FIXa complex are presented based on agreements with known experimental data and according to structural criteria.
PubMed 127. A founder factor VIII mutation, valine 2016 to alanine, was found in a Newfoundland population with an extraordinarily high prevalence of mild hemophilia A.
PubMed 128. No mutations at the APC interacting sites exons 8, 11, & 19) of factor VIII were found in Caucasians with recurrent deep venous thrombosis.
PubMed 129. epitope specificity, FVIII antibody mechanism of FVIII inactivation, and their relationship with FVIII genetic alterations
PubMed 130. Reported nine novel (6 deletions, two indels and one partial duplication) and five recurrent small rearrangements identified in 15 German patients with severe hemophilia A.
PubMed 131. Seven novel mutations causing severe, moderate and mild Hemophilia A.
PubMed 132. results indicate a markedly reduced rate of cleavage following substitution at the P(1)Arg. However, prolonged reaction with thrombin yielded similar activity and stability values, reflecting the moderate severity of this hemophilia A phenotype
PubMed 133. Forty-one novel causative factor VIII gene mutations have been identified and classified in hemophiliacs.
PubMed 134. mutational screening of 18 unrelated Italian patients affected with Hemophilia A of varying severity identified 5 movel mutations; consequences of each missense mutation and the effect of the amino acid change on structural FVIII models was visualized
PubMed 135. antibodies against FVIII acidic regions can inhibit FVIII function by a variety of mechanisms, in particular by interfering with the binding of FVIII to phospholipids & VWF.
PubMed 136. Polymerized fibrin can function as a platelet co-stimulus, up-regulating expression of binding sites for FVIIIa
PubMed 137. 95 novel mutations within the coalgulation factor VIII gene are associated with hemophilia A.
PubMed 138. Patients with elevated levels of FVIII should be screened for blood group, as the non-O group confers a particularly high risk for arterial occlusive diseases.
PubMed 139. Activation by thrombin dramatically increased fVIII affinity for LDL but not HDL, which may be related to differences in phospholipid composition of the LPs.
PubMed 140. Following the the fate of the chimeric embryo in a blastomere marked with the human blood coagulation factor VIII (hFVIII in rabbit germline.
PubMed 141. identified F8 A2 domain epitopes recognized by CD4+ T cells and compared proliferative responses of CD4+ T cells from hemophilia patients and healthy controls to these F8 epitopes
PubMed 142. analysis of novel mutations in the factor VIII gene in Indian patients with hemophilia A
PubMed 143. in the presence of Ca2+, phospholipid, and FVIIIa, binding of Na+ to factor IXa increases its biologic activity
PubMed 144. cupredoxin-like A1 subdomains in fVIII contain inter-species differences that are a result of selective pressure on the dissociation rate constant
PubMed 145. The role of factor VIII in tissue factor-initiated spatial clot growth was studied on fibroblast monolayers in recalcified plasma from severe haemophilia A. Functioning of the intrinsic tenase complex is critical for normal spatial clot growth.
PubMed 146. increased procoagulant activity due to formation of additional fVIII phosphatidylserine binding sites on the outer surface of oxLDL-treated cells and higher binding affinity between components of the Xase complex, activated factors VIII and IX.
PubMed 147. an interaction between LMAN1 and FVIII in vivo was mediated via high mannose-containing asparagine-linked oligosaccharides that are densely situated within the B domain of FVIII, as well as protein-protein interactions
PubMed 148. FIXa/FVIIIa binding studies of coordinate binding of FVIIIa and FX to equivalent numbers of binding sites on activated platelets provide strong evidence that FVIIIa comprises the receptor that presents FX to FIXa for catalysis on the platelet membrane.
PubMed 149. analysis of epitope repertoire of coagulation factor VIII in hemophilia A patients and healthy subjects
PubMed 150. Cause of hemophilia A is either absence or rapid degradation of the F8 mRNA.
PubMed 151. venous thromboembolism patients showed a significantly higher plasma FVIII/VWF ratio
PubMed 152. factor VIII coagulant activity is restored by exon skipping in patients with mild hemophilia A with exon 13 duplication
PubMed 153. Alu-repetitive elements are directly involved in the origin of a novel large FVIII gene deletion caused by unequal homologous Alu/Alu recombination in a severe hemophilia A patient
PubMed 154. 3-Dimensional structure of membrane-bound coagulation factor VIII from electron crystallography
PubMed 155. mutation, or lack of mutation in this protein in hemophilia A
PubMed 156. studied a group of healthy non-bleeding women to evaluate normal ranges OF F8 and VWF and their relationship to blood group and parity in normal pregnancy, and the return to non-pregnant factor levels in puerperium
PubMed 157. coagulation factor VIII has a specific domain (A3) for binding low density lipoprotein receptor-related protein and factor IXa
PubMed 158. Disease-causing alterations within the F8 gene were identified in 177 hemophilia A families of Portuguese origin.
PubMed 159. propose that LRP binding of non-activated FVIII is mediated via the FVIII light chain while in activated FVIII both the heavy and light chain contribute to LRP binding.
PubMed 160. formation of TF-FVIIa-FXa complex prevents apoptosis in breast cancer cells by a thrombin-independent pathway
PubMed 161. FXIII-A is expressed in leukemic lymphoblasts
PubMed 162. inactivating mutations in MCFD2 cause combined deficiency of factor V and factor VIII with a phenotype indistinguishable from that caused by mutations in LMAN1
PubMed 163. a cluster of acidic residues at position 361-363 contribute to a unique factor Xa-interactive site within the factor VIII heavy chain that promotes factor Xa docking during cofactor activation
PubMed 164. Inhibitory antibody response to human factor VIII can be reduced by mutagenesis of a B-cell epitope without apparent loss of function: may be a safer form of factor VIII in patients with hemophilia A.
PubMed 165. FVIII152-159 represents a dominant CTL epitope
PubMed 166. The combination of -25C/G LRP polymorphism with FVIII D1241E and ABO polymorphisms produced a gradient of FVIII levels; post-translational modification and removal from circulation, have additive effects on the variance of FVIII levels in plasma.
PubMed 167. R763G is a new type 2N VWD mutation located in the VWF propeptide which alters the proteolytic processing of VWF and consequently its binding to FVIII
PubMed 168. document crucial roles for von Willebrand factor and FVIII in experimental thrombosis under venous flow conditions in vivo
PubMed 169. This study shows that FVIII activity in hemophilia A heterozygous females can be directly related to X-chromosome inactivation skewing, and that low FVIII activity in females in this family is due to unfavourable XCI skewing.
Submit: New GeneRIF Correction

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
 
  NP_000123.1   Calreticulin   CALR      HPRD    PubMed
 
  NP_000123.1   Calnexin   CANX      HPRD    PubMed
 
  NP_000123.1   Coagulation factor X   F10      HPRD    PubMed
 
  NP_000123.1   Coagulation factor IX   F9      HPRD    PubMed
 
  NP_000123.1   Coagulation factor IX   F9      HPRD    PubMed
 
  NP_000123.1   NP_005338.1   HSPA5      HPRD    PubMed
 
  NP_000123.1   NP_005338.1   HSPA5      HPRD    PubMed
 
  NP_000123.1   Lectin mannose binding 1   LMAN1      HPRD    PubMed
 
  NP_000123.1   NP_002323.1   LRP1      HPRD    PubMed
 
  NP_000123.1   Phytanoyl CoA hydroxylase   PHYH      HPRD    PubMed
 
  NP_000123.1   Protein C   PROC      HPRD    PubMed
 
  NP_000123.1   NP_000304.1   PROS1      HPRD    PubMed
 
  NP_000123.1   von Willebrand factor   VWF      HPRD    PubMed
 
  NP_000123.1   IgG4kappa Fab Heavy Chain        HPRD    PubMed
 
  NP_000123.1   IgG4kappa Fab Light Chain        HPRD    PubMed
Affinity Capture-Western
  BioGRID:108455   BioGRID:107271   CANX      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108455   BioGRID:108457   F10      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:108455   BioGRID:110185   LMAN1      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108455   BioGRID:110215   LRP1      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex; Two-hybrid
  BioGRID:108455   BioGRID:111282   PHYH      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108455   BioGRID:111611   PROS1      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108455   BioGRID:113289   VWF      BioGRID    PubMed

[Top][Help]General gene information

Markers

REN90946(e-PCR)
Links: UniSTS:415744
REN91202(e-PCR)
Links: UniSTS:416000
REN90947(e-PCR)
Links: UniSTS:415745
REN91203(e-PCR)
Links: UniSTS:416001
REN90948(e-PCR)
Links: UniSTS:415746
REN91204(e-PCR)
Links: UniSTS:416002
REN90949(e-PCR)
Links: UniSTS:415747
REN91205(e-PCR)
Links: UniSTS:416003
ECD21859(e-PCR)
Links: UniSTS:302851
ECD24427(e-PCR)
Links: UniSTS:305411
REN90950(e-PCR)
Links: UniSTS:415748
REN91206(e-PCR)
Links: UniSTS:416004
REN90951(e-PCR)
Links: UniSTS:415749
REN91207(e-PCR)
Links: UniSTS:416005
ECD04373(e-PCR)
Links: UniSTS:285445
REN90952(e-PCR)
Links: UniSTS:415750
REN91208(e-PCR)
Links: UniSTS:416006
ECD23918(e-PCR)
Links: UniSTS:304902
REN90953(e-PCR)
Links: UniSTS:415751
REN91209(e-PCR)
Links: UniSTS:416007
REN90954(e-PCR)
Links: UniSTS:415752
REN91210(e-PCR)
Links: UniSTS:416008
DXS7532(e-PCR)
Links: UniSTS:57864
REN90955(e-PCR)
Links: UniSTS:415753
REN91211(e-PCR)
Links: UniSTS:416009
REN90956(e-PCR)
Links: UniSTS:415754
REN91212(e-PCR)
Links: UniSTS:416010
REN90957(e-PCR)
Links: UniSTS:415755
REN91213(e-PCR)
Links: UniSTS:416011
ECD09786(e-PCR)
Links: UniSTS:290827
ECD24179(e-PCR)
Links: UniSTS:305163
REN90958(e-PCR)
Links: UniSTS:415756
REN91214(e-PCR)
Links: UniSTS:416012
REN90959(e-PCR)
Links: UniSTS:415757
REN91215(e-PCR)
Links: UniSTS:416013
REN90960(e-PCR)
Links: UniSTS:415758
REN91216(e-PCR)
Links: UniSTS:416014
REN90961(e-PCR)
Links: UniSTS:415759
REN91217(e-PCR)
Links: UniSTS:416015
ECD03347(e-PCR)
Links: UniSTS:284432
REN90962(e-PCR)
Links: UniSTS:415760
REN91218(e-PCR)
Links: UniSTS:416016
REN90963(e-PCR)
Links: UniSTS:415761
REN91219(e-PCR)
Links: UniSTS:416017
REN90964(e-PCR)
Links: UniSTS:415762
REN91220(e-PCR)
Links: UniSTS:416018
REN90965(e-PCR)
Links: UniSTS:415763
REN91221(e-PCR)
Links: UniSTS:416019
REN90966(e-PCR)
Links: UniSTS:415764
REN91222(e-PCR)
Links: UniSTS:416020
REN90967(e-PCR)
Links: UniSTS:415765
REN91223(e-PCR)
Links: UniSTS:416021
REN90968(e-PCR)
Links: UniSTS:415766
REN91224(e-PCR)
Links: UniSTS:416022
REN90969(e-PCR)
Links: UniSTS:415767
REN91225(e-PCR)
Links: UniSTS:416023
GDB:177507(e-PCR)
Links: UniSTS:154903
REN90970(e-PCR)
Links: UniSTS:415768
REN91226(e-PCR)
Links: UniSTS:416024
REN90971(e-PCR)
Links: UniSTS:415769
REN91227(e-PCR)
Links: UniSTS:416025
REN90972(e-PCR)
Links: UniSTS:415770
REN91228(e-PCR)
Links: UniSTS:416026
GDB:177519(e-PCR)
Links: UniSTS:154906
REN90973(e-PCR)
Links: UniSTS:415771
REN91229(e-PCR)
Links: UniSTS:416027
ECD16740(e-PCR)
Links: UniSTS:297755
REN90974(e-PCR)
Links: UniSTS:415772
REN91230(e-PCR)
Links: UniSTS:416028
REN90975(e-PCR)
Links: UniSTS:415773
REN91231(e-PCR)
Links: UniSTS:416029
REN90976(e-PCR)
Links: UniSTS:415774
REN91232(e-PCR)
Links: UniSTS:416030
ECD18539(e-PCR)
Links: UniSTS:299550
REN90977(e-PCR)
Links: UniSTS:415775
REN91233(e-PCR)
Links: UniSTS:416031
ECD15462(e-PCR)
Links: UniSTS:296479
REN90978(e-PCR)
Links: UniSTS:415776
REN91234(e-PCR)
Links: UniSTS:416032
REN90979(e-PCR)
Links: UniSTS:415777
REN91235(e-PCR)
Links: UniSTS:416033
REN91236(e-PCR)
Links: UniSTS:416034
REN90981(e-PCR)
Links: UniSTS:415779
REN91237(e-PCR)
Links: UniSTS:416035
ECD08011(e-PCR)
Links: UniSTS:289059
REN90982(e-PCR)
Links: UniSTS:415780
REN91238(e-PCR)
Links: UniSTS:416036
ECD02848(e-PCR)
Links: UniSTS:283941
REN90983(e-PCR)
Links: UniSTS:415781
REN91239(e-PCR)
Links: UniSTS:416037
REN90984(e-PCR)
Links: UniSTS:415782
REN91240(e-PCR)
Links: UniSTS:416038
REN90985(e-PCR)
Links: UniSTS:415783
REN91241(e-PCR)
Links: UniSTS:416039
ECD04921(e-PCR)
Links: UniSTS:285991
REN90986(e-PCR)
Links: UniSTS:415784
REN91242(e-PCR)
Links: UniSTS:416040
REN90987(e-PCR)
Links: UniSTS:415785
REN91243(e-PCR)
Links: UniSTS:416041
REN90988(e-PCR)
Links: UniSTS:415786
REN91244(e-PCR)
Links: UniSTS:416042
REN90989(e-PCR)
Links: UniSTS:415787
REN91245(e-PCR)
Links: UniSTS:416043
REN90990(e-PCR)
Links: UniSTS:415788
REN90991(e-PCR)
Links: UniSTS:415789
REN91247(e-PCR)
Links: UniSTS:416045
STS-M14113(e-PCR)
Links: UniSTS:50477
REN90992(e-PCR)
Links: UniSTS:415790
REN91248(e-PCR)
Links: UniSTS:416046
REN90993(e-PCR)
Links: UniSTS:415791
REN91249(e-PCR)
Links: UniSTS:416047
ECD13417(e-PCR)
Links: UniSTS:294447
REN90994(e-PCR)
Links: UniSTS:415792
REN91250(e-PCR)
Links: UniSTS:416048
REN90995(e-PCR)
Links: UniSTS:415793
REN91251(e-PCR)
Links: UniSTS:416049
GDB:177561(e-PCR)
Links: UniSTS:154929
GDB:192156(e-PCR)
Links: UniSTS:155697
REN90996(e-PCR)
Links: UniSTS:415794
REN91252(e-PCR)
Links: UniSTS:416050
REN90997(e-PCR)
Links: UniSTS:415795
REN91253(e-PCR)
Links: UniSTS:416051
REN90998(e-PCR)
Links: UniSTS:415796
REN91254(e-PCR)
Links: UniSTS:416052
REN90999(e-PCR)
Links: UniSTS:415797
REN91255(e-PCR)
Links: UniSTS:416053
ECD10854(e-PCR)
Links: UniSTS:291893
REN91000(e-PCR)
Links: UniSTS:415798
REN91256(e-PCR)
Links: UniSTS:416054
ECD20106(e-PCR)
Links: UniSTS:301110
REN91001(e-PCR)
Links: UniSTS:415799
REN91257(e-PCR)
Links: UniSTS:416055
REN91002(e-PCR)
Links: UniSTS:415800
REN91258(e-PCR)
Links: UniSTS:416056
ECD09058(e-PCR)
Links: UniSTS:290104
REN91003(e-PCR)
Links: UniSTS:415801
REN91259(e-PCR)
Links: UniSTS:416057
REN91004(e-PCR)
Links: UniSTS:415802
REN91260(e-PCR)
Links: UniSTS:416058
REN91005(e-PCR)
Links: UniSTS:415803
REN91261(e-PCR)
Links: UniSTS:416059
REN91006(e-PCR)
Links: UniSTS:415804
REN91262(e-PCR)
Links: UniSTS:416060
ECD21916(e-PCR)
Links: UniSTS:302908
REN91007(e-PCR)
Links: UniSTS:415805
REN91263(e-PCR)
Links: UniSTS:416061
ECD08805(e-PCR)
Links: UniSTS:289853
REN91008(e-PCR)
Links: UniSTS:415806
REN91264(e-PCR)
Links: UniSTS:416062
REN91009(e-PCR)
Links: UniSTS:415807
REN91265(e-PCR)
Links: UniSTS:416063
REN91010(e-PCR)
Links: UniSTS:415808
REN91266(e-PCR)
Links: UniSTS:416064
REN91011(e-PCR)
Links: UniSTS:415809
REN91267(e-PCR)
Links: UniSTS:416065
ECD06493(e-PCR)
Links: UniSTS:287553
REN91012(e-PCR)
Links: UniSTS:415810
REN91268(e-PCR)
Links: UniSTS:416066
REN91013(e-PCR)
Links: UniSTS:415811
REN91269(e-PCR)
Links: UniSTS:416067
REN91014(e-PCR)
Links: UniSTS:415812
REN91270(e-PCR)
Links: UniSTS:416068
REN91271(e-PCR)
Links: UniSTS:416069
ECD03143(e-PCR)
Links: UniSTS:284230
REN91016(e-PCR)
Links: UniSTS:415814
REN91272(e-PCR)
Links: UniSTS:416070
REN91017(e-PCR)
Links: UniSTS:415815
REN91273(e-PCR)
Links: UniSTS:416071
GDB:177706(e-PCR)
Links: UniSTS:154951
REN91018(e-PCR)
Links: UniSTS:415816
REN91274(e-PCR)
Links: UniSTS:416072
REN91019(e-PCR)
Links: UniSTS:415817
REN91275(e-PCR)
Links: UniSTS:416073
HSC271_(M4)(e-PCR)
Links: UniSTS:273738
REN91020(e-PCR)
Links: UniSTS:415818
REN91276(e-PCR)
Links: UniSTS:416074
REN91021(e-PCR)
Links: UniSTS:415819
REN91277(e-PCR)
Links: UniSTS:416075
ECD09850(e-PCR)
Links: UniSTS:290891
REN91022(e-PCR)
Links: UniSTS:415820
REN91278(e-PCR)
Links: UniSTS:416076
REN91023(e-PCR)
Links: UniSTS:415821
REN91279(e-PCR)
Links: UniSTS:416077
ECD03412(e-PCR)
Links: UniSTS:284494
REN91024(e-PCR)
Links: UniSTS:415822
REN91280(e-PCR)
Links: UniSTS:416078
REN91025(e-PCR)
Links: UniSTS:415823
REN91281(e-PCR)
Links: UniSTS:416079
REN91026(e-PCR)
Links: UniSTS:415824
REN91282(e-PCR)
Links: UniSTS:416080
REN91027(e-PCR)
Links: UniSTS:415825
REN91283(e-PCR)
Links: UniSTS:416081
REN91028(e-PCR)
Links: UniSTS:415826
REN91284(e-PCR)
Links: UniSTS:416082
REN91029(e-PCR)
Links: UniSTS:415827
REN91285(e-PCR)
Links: UniSTS:416083
REN91030(e-PCR)
Links: UniSTS:415828
REN91286(e-PCR)
Links: UniSTS:416084
REN91031(e-PCR)
Links: UniSTS:415829
REN91287(e-PCR)
Links: UniSTS:416085
REN91032(e-PCR)
Links: UniSTS:415830
REN91288(e-PCR)
Links: UniSTS:416086
REN91033(e-PCR)
Links: UniSTS:415831
REN91289(e-PCR)
Links: UniSTS:416087
REN91034(e-PCR)
Links: UniSTS:415832
REN91290(e-PCR)
Links: UniSTS:416088
REN91035(e-PCR)
Links: UniSTS:415833
REN91291(e-PCR)
Links: UniSTS:416089
REN91036(e-PCR)
Links: UniSTS:415834
REN91292(e-PCR)
Links: UniSTS:416090
GDB:177816(e-PCR)
Links: UniSTS:154970
ECD06004(e-PCR)
Links: UniSTS:287066
REN91037(e-PCR)
Links: UniSTS:415835
REN91293(e-PCR)
Links: UniSTS:416091
REN91038(e-PCR)
Links: UniSTS:415836
REN91294(e-PCR)
Links: UniSTS:416092
REN91039(e-PCR)
Links: UniSTS:415837
REN91295(e-PCR)
Links: UniSTS:416093
ECD14238(e-PCR)
Links: UniSTS:295261
REN91040(e-PCR)
Links: UniSTS:415838
REN91296(e-PCR)
Links: UniSTS:416094
REN91041(e-PCR)
Links: UniSTS:415839
REN91297(e-PCR)
Links: UniSTS:416095
REN91042(e-PCR)
Links: UniSTS:415840
REN91298(e-PCR)
Links: UniSTS:416096
REN91043(e-PCR)
Links: UniSTS:415841
REN91299(e-PCR)
Links: UniSTS:416097
REN90020(e-PCR)
Links: UniSTS:414818
REN91044(e-PCR)
Links: UniSTS:415842
REN91300(e-PCR)
Links: UniSTS:416098
REN91045(e-PCR)
Links: UniSTS:415843
REN91301(e-PCR)
Links: UniSTS:416099
ECD10131(e-PCR)
Links: UniSTS:291171
REN91046(e-PCR)
Links: UniSTS:415844
REN91302(e-PCR)
Links: UniSTS:416100
REN91047(e-PCR)
Links: UniSTS:415845
REN91303(e-PCR)
Links: UniSTS:416101
REN91048(e-PCR)
Links: UniSTS:415846
REN91304(e-PCR)
Links: UniSTS:416102
REN91305(e-PCR)
Links: UniSTS:416103
REN91050(e-PCR)
Links: UniSTS:415848
REN91306(e-PCR)
Links: UniSTS:416104
REN91051(e-PCR)
Links: UniSTS:415849
REN91307(e-PCR)
Links: UniSTS:416105
REN91052(e-PCR)
Links: UniSTS:415850
REN91308(e-PCR)
Links: UniSTS:416106
REN91053(e-PCR)
Links: UniSTS:415851
REN91309(e-PCR)
Links: UniSTS:416107
REN91054(e-PCR)
Links: UniSTS:415852
REN91310(e-PCR)
Links: UniSTS:416108
REN91055(e-PCR)
Links: UniSTS:415853
REN91311(e-PCR)
Links: UniSTS:416109
REN91056(e-PCR)
Links: UniSTS:415854
REN91312(e-PCR)
Links: UniSTS:416110
ECD03445(e-PCR)
Links: UniSTS:284527
REN91057(e-PCR)
Links: UniSTS:415855
REN91313(e-PCR)
Links: UniSTS:416111
REN91058(e-PCR)
Links: UniSTS:415856
REN91314(e-PCR)
Links: UniSTS:416112
REN91059(e-PCR)
Links: UniSTS:415857
REN91315(e-PCR)
Links: UniSTS:416113
REN91060(e-PCR)
Links: UniSTS:415858
REN91316(e-PCR)
Links: UniSTS:416114
REN91061(e-PCR)
Links: UniSTS:415859
REN91317(e-PCR)
Links: UniSTS:416115
ECD12714(e-PCR)
Links: UniSTS:293747
REN91062(e-PCR)
Links: UniSTS:415860
REN91318(e-PCR)
Links: UniSTS:416116
REN91063(e-PCR)
Links: UniSTS:415861
REN91319(e-PCR)
Links: UniSTS:416117
ECD11433(e-PCR)
Links: UniSTS:292469
REN91064(e-PCR)
Links: UniSTS:415862
REN91320(e-PCR)
Links: UniSTS:416118
REN91065(e-PCR)
Links: UniSTS:415863
REN91321(e-PCR)
Links: UniSTS:416119
REN91066(e-PCR)
Links: UniSTS:415864
REN91322(e-PCR)
Links: UniSTS:416120
REN91067(e-PCR)
Links: UniSTS:415865
REN91323(e-PCR)
Links: UniSTS:416121
REN91068(e-PCR)
Links: UniSTS:415866
REN91324(e-PCR)
Links: UniSTS:416122
REN91069(e-PCR)
Links: UniSTS:415867
REN91325(e-PCR)
Links: UniSTS:416123
REN91070(e-PCR)
Links: UniSTS:415868
REN91326(e-PCR)
Links: UniSTS:416124
REN91071(e-PCR)
Links: UniSTS:415869
REN91327(e-PCR)
Links: UniSTS:416125
ECD08613(e-PCR)
Links: UniSTS:289661
REN91072(e-PCR)
Links: UniSTS:415870
REN91328(e-PCR)
Links: UniSTS:416126
ECD14272(e-PCR)
Links: UniSTS:295294
REN91073(e-PCR)
Links: UniSTS:415871
REN91329(e-PCR)
Links: UniSTS:416127
REN91074(e-PCR)
Links: UniSTS:415872
REN91330(e-PCR)
Links: UniSTS:416128
REN91075(e-PCR)
Links: UniSTS:415873
REN91331(e-PCR)
Links: UniSTS:416129
REN91076(e-PCR)
Links: UniSTS:415874
REN91332(e-PCR)
Links: UniSTS:416130
ECD06300(e-PCR)
Links: UniSTS:287362
REN91077(e-PCR)
Links: UniSTS:415875
REN91333(e-PCR)
Links: UniSTS:416131
ECD06301(e-PCR)
Links: UniSTS:287363
REN91078(e-PCR)
Links: UniSTS:415876
REN91334(e-PCR)
Links: UniSTS:416132
REN91079(e-PCR)
Links: UniSTS:415877
REN91335(e-PCR)
Links: UniSTS:416133
REN91080(e-PCR)
Links: UniSTS:415878
REN91336(e-PCR)
Links: UniSTS:416134
ECD19159(e-PCR)
Links: UniSTS:300166
REN91081(e-PCR)
Links: UniSTS:415879
REN91337(e-PCR)
Links: UniSTS:416135
REN91082(e-PCR)
Links: UniSTS:415880
REN91338(e-PCR)
Links: UniSTS:416136
REN91083(e-PCR)
Links: UniSTS:415881
REN91339(e-PCR)
Links: UniSTS:416137
REN91084(e-PCR)
Links: UniSTS:415882
REN91340(e-PCR)
Links: UniSTS:416138
REN91085(e-PCR)
Links: UniSTS:415883
REN91341(e-PCR)
Links: UniSTS:416139
stSG604314(e-PCR)
Links: UniSTS:447627
REN91086(e-PCR)
Links: UniSTS:415884
REN91342(e-PCR)
Links: UniSTS:416140
REN91087(e-PCR)
Links: UniSTS:415885
REN91343(e-PCR)
Links: UniSTS:416141
ECD21482(e-PCR)
Links: UniSTS:302477
ECD24309(e-PCR)
Links: UniSTS:305293
ECD00116(e-PCR)
Links: UniSTS:281230
REN91088(e-PCR)
Links: UniSTS:415886
REN91344(e-PCR)
Links: UniSTS:416142
ECD06570(e-PCR)
Links: UniSTS:287630
ECD23286(e-PCR)
Links: UniSTS:304270
ECD01666(e-PCR)
Links: UniSTS:282767
REN91089(e-PCR)
Links: UniSTS:415887
REN91345(e-PCR)
Links: UniSTS:416143
REN91090(e-PCR)
Links: UniSTS:415888
REN91346(e-PCR)
Links: UniSTS:416144
ECD10689(e-PCR)
Links: UniSTS:291728
REN90835(e-PCR)
Links: UniSTS:415633
REN91091(e-PCR)
Links: UniSTS:415889
REN91347(e-PCR)
Links: UniSTS:416145
ECD15064(e-PCR)
Links: UniSTS:296081
REN90836(e-PCR)
Links: UniSTS:415634
REN91092(e-PCR)
Links: UniSTS:415890
REN91348(e-PCR)
Links: UniSTS:416146
REN90837(e-PCR)
Links: UniSTS:415635
REN91093(e-PCR)
Links: UniSTS:415891
REN91349(e-PCR)
Links: UniSTS:416147
REN90838(e-PCR)
Links: UniSTS:415636
REN91094(e-PCR)
Links: UniSTS:415892
REN91350(e-PCR)
Links: UniSTS:416148
stSG604326(e-PCR)
Links: UniSTS:447636
REN90839(e-PCR)
Links: UniSTS:415637
REN91095(e-PCR)
Links: UniSTS:415893
REN91351(e-PCR)
Links: UniSTS:416149
stSG604327(e-PCR)
Links: UniSTS:447637
REN90840(e-PCR)
Links: UniSTS:415638
REN91096(e-PCR)
Links: UniSTS:415894
REN91352(e-PCR)
Links: UniSTS:416150
ECD22781(e-PCR)
Links: UniSTS:303766
stSG604328(e-PCR)
Links: UniSTS:447638
REN90841(e-PCR)
Links: UniSTS:415639
REN91097(e-PCR)
Links: UniSTS:415895
REN91353(e-PCR)
Links: UniSTS:416151
ECD11467(e-PCR)
Links: UniSTS:292503
stSG604329(e-PCR)
Links: UniSTS:447639
REN90842(e-PCR)
Links: UniSTS:415640
REN91098(e-PCR)
Links: UniSTS:415896
REN91354(e-PCR)
Links: UniSTS:416152
stSG604331(e-PCR)
Links: UniSTS:447640
REN90843(e-PCR)
Links: UniSTS:415641
REN91099(e-PCR)
Links: UniSTS:415897
REN91355(e-PCR)
Links: UniSTS:416153
stSG604332(e-PCR)
Links: UniSTS:447641
REN91100(e-PCR)
Links: UniSTS:415898
stSG604333(e-PCR)
Links: UniSTS:447642
REN91101(e-PCR)
Links: UniSTS:415899
stSG604334(e-PCR)
Links: UniSTS:447643
REN91102(e-PCR)
Links: UniSTS:415900
stSG604336(e-PCR)
Links: UniSTS:447644
stSG604337(e-PCR)
Links: UniSTS:447645
stSG604339(e-PCR)
Links: UniSTS:447646
REN91105(e-PCR)
Links: UniSTS:415903
stSG604340(e-PCR)
Links: UniSTS:447647
REN91106(e-PCR)
Links: UniSTS:415904
ECD19185(e-PCR)
Links: UniSTS:300192
stSG604341(e-PCR)
Links: UniSTS:447648
REN91107(e-PCR)
Links: UniSTS:415905
GDB:452843(e-PCR)
Links: UniSTS:99489
stSG604342(e-PCR)
Links: UniSTS:447649
REN91108(e-PCR)
Links: UniSTS:415906
stSG604343(e-PCR)
Links: UniSTS:447650
REN91109(e-PCR)
Links: UniSTS:415907
stSG604344(e-PCR)
Links: UniSTS:447651
REN91110(e-PCR)
Links: UniSTS:415908
stSG604345(e-PCR)
Links: UniSTS:447652
REN91111(e-PCR)
Links: UniSTS:415909
stSG604346(e-PCR)
Links: UniSTS:447653
REN91112(e-PCR)
Links: UniSTS:415910
stSG604347(e-PCR)
Links: UniSTS:447654
REN91113(e-PCR)
Links: UniSTS:415911
stSG604348(e-PCR)
Links: UniSTS:447655
REN91114(e-PCR)
Links: UniSTS:415912
stSG604349(e-PCR)
Links: UniSTS:447656
REN91115(e-PCR)
Links: UniSTS:415913
stSG604350(e-PCR)
Links: UniSTS:447657
REN91116(e-PCR)
Links: UniSTS:415914
ECD20222(e-PCR)
Links: UniSTS:301226
stSG604351(e-PCR)
Links: UniSTS:447658
REN91117(e-PCR)
Links: UniSTS:415915
stSG604352(e-PCR)
Links: UniSTS:447659
REN91118(e-PCR)
Links: UniSTS:415916
stSG604353(e-PCR)
Links: UniSTS:447660
REN91119(e-PCR)
Links: UniSTS:415917
stSG604355(e-PCR)
Links: UniSTS:447661
REN91120(e-PCR)
Links: UniSTS:415918
stSG604356(e-PCR)
Links: UniSTS:447662
REN91121(e-PCR)
Links: UniSTS:415919
stSG604357(e-PCR)
Links: UniSTS:447663
REN91122(e-PCR)
Links: UniSTS:415920
stSG604358(e-PCR)
Links: UniSTS:447664
REN91123(e-PCR)
Links: UniSTS:415921
stSG604359(e-PCR)
Links: UniSTS:447665
REN91124(e-PCR)
Links: UniSTS:415922
stSG604360(e-PCR)
Links: UniSTS:447666
ECD00153(e-PCR)
Links: UniSTS:281267
REN91125(e-PCR)
Links: UniSTS:415923
ECD14326(e-PCR)
Links: UniSTS:295347
stSG604361(e-PCR)
Links: UniSTS:447667
REN91126(e-PCR)
Links: UniSTS:415924
ECD23324(e-PCR)
Links: UniSTS:304308
stSG604362(e-PCR)
Links: UniSTS:447668
REN91127(e-PCR)
Links: UniSTS:415925
stSG604363(e-PCR)
Links: UniSTS:447669
REN91128(e-PCR)
Links: UniSTS:415926
stSG604364(e-PCR)
Links: UniSTS:447670
REN91129(e-PCR)
Links: UniSTS:415927
NoName(e-PCR)
Links: UniSTS:488119
stSG604365(e-PCR)
Links: UniSTS:447671
REN91130(e-PCR)
Links: UniSTS:415928
stSG604366(e-PCR)
Links: UniSTS:447672
REN91131(e-PCR)
Links: UniSTS:415929
stSG604367(e-PCR)
Links: UniSTS:447673
REN91132(e-PCR)
Links: UniSTS:415930
stSG604368(e-PCR)
Links: UniSTS:447674
REN91133(e-PCR)
Links: UniSTS:415931
ECD20757(e-PCR)
Links: UniSTS:301755
stSG604369(e-PCR)
Links: UniSTS:447675
REN91134(e-PCR)
Links: UniSTS:415932
ECD20758(e-PCR)
Links: UniSTS:301756
stSG604370(e-PCR)
Links: UniSTS:447676
REN91135(e-PCR)
Links: UniSTS:415933
stSG604371(e-PCR)
Links: UniSTS:447677
REN91136(e-PCR)
Links: UniSTS:415934
stSG604372(e-PCR)
Links: UniSTS:447678
REN91137(e-PCR)
Links: UniSTS:415935
ECD21791(e-PCR)
Links: UniSTS:302783
stSG604373(e-PCR)
Links: UniSTS:447679
REN91138(e-PCR)
Links: UniSTS:415936
stSG604374(e-PCR)
Links: UniSTS:447680
REN91139(e-PCR)
Links: UniSTS:415937
ECD20246(e-PCR)
Links: UniSTS:301249
stSG604375(e-PCR)
Links: UniSTS:447681
REN91140(e-PCR)
Links: UniSTS:415938
stSG604376(e-PCR)
Links: UniSTS:447682
REN91141(e-PCR)
Links: UniSTS:415939
stSG604377(e-PCR)
Links: UniSTS:447683
REN91142(e-PCR)
Links: UniSTS:415940
stSG604378(e-PCR)
Links: UniSTS:447684
REN91143(e-PCR)
Links: UniSTS:415941
stSG604379(e-PCR)
Links: UniSTS:447685
REN91144(e-PCR)
Links: UniSTS:415942
ECD09459(e-PCR)
Links: UniSTS:290502
stSG604380(e-PCR)
Links: UniSTS:447686
REN91145(e-PCR)
Links: UniSTS:415943
ECD09460(e-PCR)
Links: UniSTS:290503
stSG604382(e-PCR)
Links: UniSTS:447687
REN91146(e-PCR)
Links: UniSTS:415944
stSG604383(e-PCR)
Links: UniSTS:447688
REN91147(e-PCR)
Links: UniSTS:415945
stSG604384(e-PCR)
Links: UniSTS:447689
REN91148(e-PCR)
Links: UniSTS:415946
stSG604385(e-PCR)
Links: UniSTS:447690
REN90893(e-PCR)
Links: UniSTS:415691
REN91149(e-PCR)
Links: UniSTS:415947
GDB:196462(e-PCR)
Links: UniSTS:155851
stSG604386(e-PCR)
Links: UniSTS:447691
REN90894(e-PCR)
Links: UniSTS:415692
REN91150(e-PCR)
Links: UniSTS:415948
stSG604388(e-PCR)
Links: UniSTS:447692
REN90895(e-PCR)
Links: UniSTS:415693
REN91151(e-PCR)
Links: UniSTS:415949
stSG604389(e-PCR)
Links: UniSTS:447693
REN90896(e-PCR)
Links: UniSTS:415694
REN91152(e-PCR)
Links: UniSTS:415950
stSG604390(e-PCR)
Links: UniSTS:447694
REN90897(e-PCR)
Links: UniSTS:415695
REN91153(e-PCR)
Links: UniSTS:415951
GDB:450201(e-PCR)
Links: UniSTS:99279
stSG604391(e-PCR)
Links: UniSTS:447695
REN90898(e-PCR)
Links: UniSTS:415696
REN91154(e-PCR)
Links: UniSTS:415952
stSG604393(e-PCR)
Links: UniSTS:447696
REN90899(e-PCR)
Links: UniSTS:415697
REN91155(e-PCR)
Links: UniSTS:415953
stSG604394(e-PCR)
Links: UniSTS:447697
REN90900(e-PCR)
Links: UniSTS:415698
REN91156(e-PCR)
Links: UniSTS:415954
stSG604395(e-PCR)
Links: UniSTS:447698
REN90901(e-PCR)
Links: UniSTS:415699
REN91157(e-PCR)
Links: UniSTS:415955
stSG604396(e-PCR)
Links: UniSTS:447699
REN90902(e-PCR)
Links: UniSTS:415700
stSG604397(e-PCR)
Links: UniSTS:447700
ECD02249(e-PCR)
Links: UniSTS:283349
REN90903(e-PCR)
Links: UniSTS:415701
REN91159(e-PCR)
Links: UniSTS:415957
stSG604398(e-PCR)
Links: UniSTS:447701
REN90904(e-PCR)
Links: UniSTS:415702
stSG604399(e-PCR)
Links: UniSTS:447702
REN90905(e-PCR)
Links: UniSTS:415703
REN91161(e-PCR)
Links: UniSTS:415959
ECD15390(e-PCR)
Links: UniSTS:296407
stSG604400(e-PCR)
Links: UniSTS:447703
REN90906(e-PCR)
Links: UniSTS:415704
REN91162(e-PCR)
Links: UniSTS:415960
ECD18726(e-PCR)
Links: UniSTS:299736
stSG604401(e-PCR)
Links: UniSTS:447704
REN90907(e-PCR)
Links: UniSTS:415705
REN91163(e-PCR)
Links: UniSTS:415961
stSG604402(e-PCR)
Links: UniSTS:447705
REN90908(e-PCR)
Links: UniSTS:415706
REN91164(e-PCR)
Links: UniSTS:415962
ECD11022(e-PCR)
Links: UniSTS:292058
stSG604403(e-PCR)
Links: UniSTS:447706
REN90909(e-PCR)
Links: UniSTS:415707
REN91165(e-PCR)
Links: UniSTS:415963
stSG604404(e-PCR)
Links: UniSTS:447707
REN90910(e-PCR)
Links: UniSTS:415708
REN91166(e-PCR)
Links: UniSTS:415964
stSG604405(e-PCR)
Links: UniSTS:447708
REN90911(e-PCR)
Links: UniSTS:415709
REN91167(e-PCR)
Links: UniSTS:415965
ECD16678(e-PCR)
Links: UniSTS:297693
ECD17705(e-PCR)
Links: UniSTS:298717
REN90912(e-PCR)
Links: UniSTS:415710
REN91168(e-PCR)
Links: UniSTS:415966
REN90913(e-PCR)
Links: UniSTS:415711
REN91169(e-PCR)
Links: UniSTS:415967
REN90914(e-PCR)
Links: UniSTS:415712
REN91170(e-PCR)
Links: UniSTS:415968
SHGC-143362(e-PCR)
Links: UniSTS:185056
REN90915(e-PCR)
Links: UniSTS:415713
REN91171(e-PCR)
Links: UniSTS:415969
REN90916(e-PCR)
Links: UniSTS:415714
REN91172(e-PCR)
Links: UniSTS:415970
REN90917(e-PCR)
Links: UniSTS:415715
REN91173(e-PCR)
Links: UniSTS:415971
REN90918(e-PCR)
Links: UniSTS:415716
REN91174(e-PCR)
Links: UniSTS:415972
REN90919(e-PCR)
Links: UniSTS:415717
REN91175(e-PCR)
Links: UniSTS:415973
REN90920(e-PCR)
Links: UniSTS:415718
REN91176(e-PCR)
Links: UniSTS:415974
ECD23374(e-PCR)
Links: UniSTS:304358
REN90921(e-PCR)
Links: UniSTS:415719
REN91177(e-PCR)
Links: UniSTS:415975
ECD14635(e-PCR)
Links: UniSTS:295655
REN90922(e-PCR)
Links: UniSTS:415720
REN91178(e-PCR)
Links: UniSTS:415976
REN90923(e-PCR)
Links: UniSTS:415721
REN91179(e-PCR)
Links: UniSTS:415977
REN90924(e-PCR)
Links: UniSTS:415722
REN91180(e-PCR)
Links: UniSTS:415978
REN90925(e-PCR)
Links: UniSTS:415723
REN91181(e-PCR)
Links: UniSTS:415979
ECD01501(e-PCR)
Links: UniSTS:282604
REN90926(e-PCR)
Links: UniSTS:415724
REN91182(e-PCR)
Links: UniSTS:415980
REN90927(e-PCR)
Links: UniSTS:415725
REN91183(e-PCR)
Links: UniSTS:415981
REN90928(e-PCR)
Links: UniSTS:415726
REN91184(e-PCR)
Links: UniSTS:415982
REN90929(e-PCR)
Links: UniSTS:415727
REN91185(e-PCR)
Links: UniSTS:415983
REN90930(e-PCR)
Links: UniSTS:415728
REN91186(e-PCR)
Links: UniSTS:415984
REN90931(e-PCR)
Links: UniSTS:415729
REN91187(e-PCR)
Links: UniSTS:415985
REN90932(e-PCR)
Links: UniSTS:415730
REN91188(e-PCR)
Links: UniSTS:415986
REN90933(e-PCR)
Links: UniSTS:415731
REN91189(e-PCR)
Links: UniSTS:415987
ECD21070(e-PCR)
Links: UniSTS:302067
ECD21584(e-PCR)
Links: UniSTS:302579
REN90934(e-PCR)
Links: UniSTS:415732
REN91190(e-PCR)
Links: UniSTS:415988
ECD19784(e-PCR)
Links: UniSTS:300788
ECD21071(e-PCR)
Links: UniSTS:302068
REN90935(e-PCR)
Links: UniSTS:415733
REN91191(e-PCR)
Links: UniSTS:415989
REN90936(e-PCR)
Links: UniSTS:415734
REN91192(e-PCR)
Links: UniSTS:415990
REN90937(e-PCR)
Links: UniSTS:415735
REN91193(e-PCR)
Links: UniSTS:415991
REN90938(e-PCR)
Links: UniSTS:415736
REN91194(e-PCR)
Links: UniSTS:415992
ECD13105(e-PCR)
Links: UniSTS:294136
REN90939(e-PCR)
Links: UniSTS:415737
REN91195(e-PCR)
Links: UniSTS:415993
REN90940(e-PCR)
Links: UniSTS:415738
REN91196(e-PCR)
Links: UniSTS:415994
REN90941(e-PCR)
Links: UniSTS:415739
REN91197(e-PCR)
Links: UniSTS:415995
ECD23907(e-PCR)
Links: UniSTS:304891
REN90942(e-PCR)
Links: UniSTS:415740
REN91198(e-PCR)
Links: UniSTS:415996
REN91199(e-PCR)
Links: UniSTS:415997
ECD06939(e-PCR)
Links: UniSTS:287997
REN90944(e-PCR)
Links: UniSTS:415742
REN91200(e-PCR)
Links: UniSTS:415998
REN90945(e-PCR)
Links: UniSTS:415743
REN91201(e-PCR)
Links: UniSTS:415999

Phenotypes

Hemophilia A
MIM: 306700

Genotypes

See F8 SNP Genotype Report
See F8 SNP Variation Viewer Report Variation View Link

Homology

Homologs of the F8 gene The F8 gene is conserved in dog, mouse, rat, and chicken.


Map Viewer (Mouse, Rat)

Pathways

KEGG pathway: Complement and coagulation cascades
04610
Reactome Event:Hemostasis
REACT_604

[Top][Help]General protein information

Preferred Names
coagulation factor VIII
Names
coagulation factor VIII
factor VIII F8B
coagulation factor VIIIc

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

Genomic

  1. NG_005114.1 Reference

    Range
    494..187429, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NG_011403.1 RefSeqGene

    Range
    5000..191935
    Download
    GenBank FASTA Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000132.3 → NP_000123.1  coagulation factor VIII isoform a precursor

    Description
    Transcript Variant: This variant (1) consists of 26 exons and encodes the full-length isoform (a)
    Source sequence(s)
    BC022513,M14113
    Consensus CDS
    CCDS35457.1
    UniProtKB/Swiss-Prot
    P00451
    UniProtKB/TrEMBL
    Q14286
    UniProtKB/TrEMBL
    Q5HY69
    Conserved Domains (3) summary
    cd00057
    Location:2195 – 2344
    Blast Score: 434
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl06664
    Location:218 – 349
    Blast Score: 177
    Cu-oxidase; Multicopper oxidase
    smart00231
    Location:2039 – 2188
    Blast Score: 369
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

  2. NM_019863.2 → NP_063916.1  coagulation factor VIII isoform b precursor

    Description
    Transcript Variant: This variant (2) contains an unique 5' exon located within intron 22 of transcript variant 1. This exon codes for eight amino acids and is spliced to exons 23-26 maintaining the reading frame. The resulting isoform (b) is considerably shorter compared to isoform a, and includes the phospholipid binding domain.
    Source sequence(s)
    BC022513,BC064380,BI547023
    Consensus CDS
    CCDS44026.1
    UniProtKB/TrEMBL
    Q14286
    Conserved Domains (3) summary
    cd00057
    Location:60 – 209
    Blast Score: 429
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    smart00231
    Location:57 – 210
    Blast Score: 317
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cl09947
    Location:4 – 52
    Blast Score: 168
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000023.10

    Range
    154064062..154250997, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_167198.1 

    Range
    4982000..5168935, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000066.1

    Range
    154222607..154409732, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_927732.1 

    Range
    1930254..2117379, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000155.1

    Range
    142607714..142796095, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001842420.1 

    Range
    247862..436243, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AC109993.4  (149772..178497)   None
  genomic   AF081784.1   AAC32196.1
  genomic   AF168366.1   AAD50437.1
  genomic   AJ131818.1   CAB40351.1
  genomic   AY769950.1   AAV85964.1
  genomic   BX470111.4   CAI41660.1
  genomic   BX842559.3   CAI41672.1
  genomic   BX842564.3   CAI41666.1
  genomic   BX890586.2   CAI43241.1
  genomic   CH471172.2   EAW72645.1
       EAW72646.1
       EAW72647.1
  genomic   DQ173562.1   ABB58721.1
  genomic   DQ173592.1   ABC25733.1
  genomic   DQ173593.1   ABC25738.1
  genomic   DQ173594.1   ABC25743.1
  genomic   DQ173595.1   ABC25748.1
  genomic   DQ173596.1   ABC25753.1
  genomic   DQ173598.1   ABC25762.1
  genomic   DQ173599.1   ABC25767.1
  genomic   DQ173600.1   ABC25772.1
  genomic   DQ173601.1   ABC25777.1
  genomic   DQ173602.1   ABC25782.1
  genomic   DQ173603.1   ABC25787.1
  genomic   DQ173604.1   ABC25792.1
  genomic   DQ173605.1   ABC25797.1
  genomic   DQ173606.1   ABC25802.1
  genomic   DQ173607.1   ABC25807.1
  genomic   DQ173608.1   ABC25812.1
  genomic   DQ173609.1   ABC25817.1
  genomic   DQ173610.1   ABC25822.1
  genomic   DQ173611.1   ABC25827.1
  genomic   DQ173612.1   ABC25832.1
  genomic   DQ173613.1   ABC25837.1
  genomic   DQ173614.1   ABC25842.1
  genomic   DQ173615.1   ABC25847.1
  genomic   DQ173616.1   ABC25852.1
  genomic   DQ173617.1   ABC25857.1
  genomic   DQ173618.1   ABC25862.1
  genomic   DQ173619.1   ABC25867.1
  genomic   DQ173620.1   ABC25872.1
  genomic   DQ173621.1   ABC25877.1
  genomic   DQ173622.1   ABC25882.1
  genomic   DQ173623.1   ABC25887.1
  genomic   DQ173624.1   ABC25892.1
  genomic   DQ173625.1   ABC25897.1
  genomic   DQ173626.1   ABC25902.1
  genomic   DQ173627.1   ABC25907.1
  genomic   DQ173628.1   ABC25912.1
  genomic   DQ173629.1   ABC25917.1
  genomic   DQ173630.1   ABC25922.1
  genomic   DQ173631.1   ABC25927.1
  genomic   DQ173632.1   ABC25932.1
  genomic   DQ173633.1   ABC25937.1
  genomic   DQ173634.1   ABC25942.1
  genomic   DQ173635.1   ABC25947.1
  genomic   DQ173636.1   ABC25952.1
  genomic   DQ173637.1   ABC25957.1
  genomic   DQ173638.1   ABC25962.1
  genomic   DQ173639.1   ABC25967.1
  genomic   DQ173640.1   ABC25972.1
  genomic   DQ173641.1   ABC25977.1
  genomic   DQ173642.1   ABC25982.1
  genomic   M88648.1   AAA52420.1
  genomic   U80228.1   AAB61261.1
  mRNA   AK289947.1   BAF82636.1
  mRNA   AK292902.1   BAF85591.1
  mRNA   AK295164.1   BAH11996.1
  mRNA   AK307726.1   None
  mRNA   AK313707.1   BAG36452.1
  mRNA   BC022513.1   AAH22513.1
  mRNA   BC064380.1   AAH64380.1
  mRNA   BC098389.1   AAH98389.1
  mRNA   BC111967.1   AAI11968.1
  mRNA   BC111969.1   AAI11970.1
  mRNA   BI547023.1   None
  mRNA   K01740.1   AAA52484.1
  mRNA   M14113.1   AAA52485.1
  mRNA   M90707.1   AAA58466.1
  mRNA   X01179.1   CAA25619.1
  other-genetic   BC166700.1   AAI66700.1
Protein Accession   Links
A0A2G2   GenPept   UniProtKB/TrEMBL:A0A2G2
A0A2G3   GenPept   UniProtKB/TrEMBL:A0A2G3
A0A2G4   GenPept   UniProtKB/TrEMBL:A0A2G4
A0A2G5   GenPept   UniProtKB/TrEMBL:A0A2G5
A0A2G6   GenPept   UniProtKB/TrEMBL:A0A2G6
A0A2G8   GenPept   UniProtKB/TrEMBL:A0A2G8
A0A2G9   GenPept   UniProtKB/TrEMBL:A0A2G9
A0FJ18   GenPept   UniProtKB/TrEMBL:A0FJ18
A0FJ19   GenPept   UniProtKB/TrEMBL:A0FJ19
A0FJ20   GenPept   UniProtKB/TrEMBL:A0FJ20
P00451.1   GenPept   UniProtKB/Swiss-Prot:P00451
Q003U9   GenPept   UniProtKB/TrEMBL:Q003U9
Q003V0   GenPept   UniProtKB/TrEMBL:Q003V0
Q003V2   GenPept   UniProtKB/TrEMBL:Q003V2
Q003V3   GenPept   UniProtKB/TrEMBL:Q003V3
Q003V4   GenPept   UniProtKB/TrEMBL:Q003V4
Q003V5   GenPept   UniProtKB/TrEMBL:Q003V5
Q003V6   GenPept   UniProtKB/TrEMBL:Q003V6
Q003V7   GenPept   UniProtKB/TrEMBL:Q003V7
Q003V8   GenPept   UniProtKB/TrEMBL:Q003V8
Q003V9   GenPept   UniProtKB/TrEMBL:Q003V9
Q003W0   GenPept   UniProtKB/TrEMBL:Q003W0
Q003W2   GenPept   UniProtKB/TrEMBL:Q003W2
Q06DL6   GenPept   UniProtKB/TrEMBL:Q06DL6
Q06DL7   GenPept   UniProtKB/TrEMBL:Q06DL7
Q06DL8   GenPept   UniProtKB/TrEMBL:Q06DL8
Q06DL9   GenPept   UniProtKB/TrEMBL:Q06DL9
Q0GE96   GenPept   UniProtKB/TrEMBL:Q0GE96
Q14286   GenPept   UniProtKB/TrEMBL:Q14286
Q2VF45   GenPept   UniProtKB/TrEMBL:Q2VF45
Q5HY69   GenPept   UniProtKB/TrEMBL:Q5HY69
Q71UI6   GenPept   UniProtKB/TrEMBL:Q71UI6
Q9UMZ8   GenPept   UniProtKB/TrEMBL:Q9UMZ8
Q9UQQ5   GenPept   UniProtKB/TrEMBL:Q9UQQ5

[Top][Help]Additional Links